Blood
Articles in this Issue
Venetoclax in combination with dasatinib, prednisone, rituximab and blinatumomab for the upfront treatment of adults with Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL), Results from a Phase 1B study
Abstract Introduction: The second-generation ABL tyrosine kinase inhibitor (TKI) dasatinib (Das) has shown impressive re...
Integrated multidisciplinary approaches to improve prognosis prediction in multiple myeloma
Abstract Introduction: Despite the therapeutic advancements in the treatment of multiple myeloma (MM) a subset of patients shows dismal prog...
Racial disparities in lymphoma: Meta-analytic insights into diagnosis and survival gaps
Abstract Introduction: Lymphomas constitute a biologically heterogeneous group of clonal lymphocytic proliferations and account for approxim...
Ivosidenib in refractory or relapsed IDH1-mutated Acute Myeloid Leukemia patients in real life settings: The ivoobs observational study from the french AML intergroup ALFA/filo
Abstract Background IDH1 R132 mutations are found in about 5-10% of AML at diagnosis. Ivosidenib (IVO) is an oral, targeted, small-molecule i...
Immunophenotypic and cytokine profiling reveal robust immunomodulation after dasatinib treatment and identify a subgroup with rapid and deep molecular response in CML patients: A multi-center prospective study
Abstract This multicenter prospective study aimed to evaluate the immunophenotypic and cytokine profiles of newly diagnosed chronic myeloid...
The core role of exosomal mir-21-5p/TGF-β1-CXCL12/RANKL axis in bone marrow microenvironment remodeling in multiple myeloma and targeted intervention strategies
Abstract Multiple myeloma (MM) drug resistance and bone disease are closely associated with the remodeling of the bone marrow microenvironme...
New class of dual agonistic T-cell engagers for the in-patient activation and expansion of v delta 1 T cells with broad antigen agnostic antitumour activity
Abstract Introduction: Gamma Delta (γδ) T cells have gained broad scientific recognition as a third subset of lymphocyte...
Transition readiness assessment in patients with bleeding disorders at Arkansas center for bleeding disorders
Abstract Background: Transitioning adolescents and young adults (AYA) with bleeding disorders to adult care is a critical process that is of...
Integrating EVI1 expression into prognostic models for MDS: Insights from IPSS-R and IPSS-m subgroup analyses
Abstract Background: EVI1 is frequently overexpressed in acute myeloid leukemia (AML) and associated with poor prognosis. Although MDS patien...
Targeting the compass complex to overcome resistance in KMT2A-rearranged Acute Myeloid Leukemia
Abstract Introduction Regulation of gene expression by histone modification is critical in drug resistance and progression. KMT2A-rearranged...
Impact of holding therapy prior to apheresis on outcomes following CD19 CAR-T cell therapy in large B-cell lymphoma
Abstract Background: Patients with relapsed or refractory large B-cell lymphoma (LBCL) often experience delays between CAR-T decision and le...
Structure-based virtual screening was performed to investigate the mechanism of action of dual-target inhibitors against FMS-like tyrosine kinase 3 (FLT3) and histone deacetylase 8 (HDAC8) in leukemia
Abstract ObjectiveThe aim of this study was to identify dual-target inhibitors of FMS-like tyrosine kinase 3 (FLT3) and histone deacetylase...
Sex-based differences in sepsis-related complications and mortality among hospitalized patients with Myelodysplastic Syndromes: A national inpatient sample analysis (2016–2022)
Abstract Background: Patients with myelodysplastic syndromes (MDS) are highly susceptible to infections, with sepsis being a major cause of...
Critical platelet shortages and a single Institution's experience with split platelet transfusions: Can you get by with just half a unit?
Abstract Introduction Blood product shortages have been a growing problem for hospital systems in the post-pandemic era. Our institution beg...
Treatment patterns and real-world effectiveness in patients with Relapsed/Refractory multiple myeloma (RRMM) and lenalidomide-exposure who received 1 to 3 prior lines of therapy
Abstract Introduction: While multiple myeloma (MM) remains incurable, proteasome inhibitors, immunomodulatory drugs, anti-CD38 monoclonal an...
Hereditary spherocytic pyropoikilocytosis: Expanding the clinical and genetic spectrum of red blood cell membrane disorders
Abstract Red blood cell (RBC) membrane disorders are a phenotypically and genetically heterogeneous group, leading to hemolytic anemia of va...
Cost comparison of prophylactic vs. on-demand use of a 1:1 ratio pdVWF/FVIII concentrate in type 3 von willebrand disease with severe bleeding phenotype in the United States: A payer and societal perspective
Abstract Background Long-term prophylaxis with von Willebrand factor (VWF) concentrate is recommended for patients with...
Hospital bed size and sepsis-related complications in patients with Myelodysplastic Syndromes: Insights from the national inpatient sample (2016–2022)
Abstract Background: Patients with myelodysplastic syndromes (MDS) are at heightened risk for severe infections, including sepsis, due to un...
Advanced myelofibrosis is marked by loss of NKG2D and DNAM-1 NK activating signaling and increased TIM-3 T CD8 exhaustion
Abstract Myelofibrosis (MF), driven by JAK/STAT signaling mutations in hematopoietic stem cells, presents the worst prognosis among myelopro...
Divergence in post-traumatic stress disorder status between children receiving hematopoietic stem cell transplantation and their primary caregivers
Abstract Background and Aims: Hematopoietic Stem Cell Transplantation(HSCT) has become a cornerstone therapy for pediatric hematological dis...
Erythrocyte aggregability as a hemodynamic marker in paroxysmal atrial fibrillation
Abstract INTRODUCTION Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with significant morbidity...
Avatrombopag: Beyond the technical sheet - a single-center experience
Abstract Introduction Avatrombopag, a 2nd-generation thrombopoietin receptor agonist (TPO-RA), is approved for chronic immune thrombocytopen...
Less‑intensive therapy in newly diagnosed acute myeloid leuekmia (AML) in India: Real-world adoption and prognostic utility of ELN‑LI and ELN‑2022 classification
Abstract Treatment of AML in India remains challenging. Delivery of intensive chemotherapy (IC) is constrained by costs and health system fa...
Clinical and economic burden of cytokine release syndrome in a nationally representative cohort of patients receiving CAR-t therapy
Abstract Introduction: Chimeric antigen receptor (CAR) T-cell therapy has emerged as an effective option for several hematologic malignancie...
Efficacy of 2nd-line treatment in CLL after venetoclax-based 1st-line treatment: Results from the GAIA/CLL13 trial
Abstract Background: Data on 2nd line treatment outcome for chronic lymphocytic leukemia (CLL) after initial venetoclax-...