Inflammatory Waldenström macroglobulinemia is associated with clonal hematopoiesis: a multicentric cohort
Abstract
Abstract Inflammatory form of Waldenström macroglobulinemia (iWM) predicts outcomes after immuno-chemotherapy and Bruton tyrosine kinase inhibitors, but its origin is unknown. Here, we unravel increased clonal hematopoiesis in patients with iWM (61% vs 23% in noninflammatory WM), suggesting a contribution of environmental cells to iWM.
Article Details
Authors (34)
Pierre-Edouard Debureaux
1Leukemia Institute Paris Saint-Louis, Paris, France
Stéphanie Poulain
Stephanie Harel
1APHP, Université Paris Cité, INSERM UMR 1342, Immno-hematologie, Paris, France
Marie Passet
2Institut de Recherche Saint-Louis, Université Paris Cité, Paris, France
Marie Templé
11Université de Paris Cité, Institut Cochin, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, INSERM U1016, Paris, France
Chloé Friedrich
7Hematobiology Unit, Cochin Hospital, Paris, France
Nathalie Forgeard
2Saint Louis Hospital, Immuno-Hematology, Paris, France
Dikelele Elessa
4Institut Paoli-Calmettes, Department of Hematology, Marseille, France
William Plas
6Hematology Laboratory, Saint-Louis Hospital, Paris, France
Laureen Chat
1Leukemia Institute Paris Saint-Louis, Paris, France
Gregory Lazarian
Lise Willems
20CHU Cochin, Hematology, Paris, France
Bruno Royer
2APHP, Paris, France
Alexis Talbot
1APHP, Université Paris Cité, INSERM UMR 1342, Immno-hematologie, Paris, France
Tristan Vaugeois
2Saint Louis Hospital, Immuno-Hematology, Paris, France
Floriane Theves
2Saint Louis Hospital, Immuno-Hematology, Paris, France
Alexandre Terre
7Tenon Hospital, Internal medecine, Paris, France
Anne Brignier
8Saint Louis Hospital, Apheresis, Paris, France
Marion Malphettes
9Saint Louis Hospital, Immuno Pathology, Paris, France
Daphne Krzisch
10Saint Louis Hospital, Hemato-Oncology, Paris, France
Laurent Frenzel
Frederic Davi
12Pitie Hospital, Laboratory of Hematology, Paris, France
Clotilde Bravetti
16Department of Hematology, Pitié-Salpêtrière Hospital, Paris, France
Florence Nguyen-Khac
31APHP, Paris, France
Jehan Dupuis
5Hôpital Henri Mondor, Lymphoid Unit, Créteil, France
Wendy Cuccuini
30Groupe Francophone de Cytogénétique Hématologique, Paris, France
Didier Bouscary
19Department of Hematology, Cochin Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France
Olivier Hermine
Damien Roos-Weil
5Drug Resistance in Hematological Malignancies Team, Centre de Recherche des Cordeliers, Université Paris Cité, INSERM UMRS 1138, Sorbonne Université, Paris, France
Olivier Kosmider
11Centre National de la Recherche Scientifique UMR8104, INSERM U1016, Institut Cochin, Université de Paris Cité, Paris, France
Emmanuelle Clappier
2Institut de Recherche Saint-Louis, Université Paris Cité, Paris, France
Marion Espéli
Karl Balabanian
Bertrand Arnulf
Hôpital Universitaire St. Louis, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris