Lymphoid malignancies in patients with Shwachman-Diamond syndrome

H Helen D. Reed (1Dana-Farber and Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA) H Hyunwoo Do (2Biostatistics and Research Design Center, Boston Children’s Hospital, Boston, MA) E Edie Weller (3Boston Children's Hospital, Boston, United States) M Marian H. Harris C Christopher R. Reilly H Harrison K. Tsai (4Department of Pathology, Boston Children’s Hospital, Boston, MA) J Jason E. Farrar (6Arkansas Children’s Research Institute, Little Rock, AR) B Bonnie W. Lau (8Department of Pediatrics, Dartmouth Health, Geisel School of Medicine at Dartmouth College, Lebanon, NH) L Lauren Pommert (7Cincinnati Children's Hospital Medical Center, Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati, United States) C Christopher Gamper (11Johns Hopkins University School of Medicine, Baltimore, MD) I Ian Atkinson (1Dana-Farber/Boston Children's Cancer and Blood Disorders Center; Harvard Medical School, Boston, United States) K Katherine Coyne (1Dana-Farber and Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA) M Margret Joos (1Dana-Farber/Boston Children's Cancer and Blood Disorders Center; Harvard Medical School, Boston, United States) S Sara Loveless (1Cincinnati Children's Hospital Medical Center, Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati, United States) S Sarah Steltz (4Boston Children's Hospital, Clinical Research Center, Boston, United States) L Leah Cheng (4Boston Children's Hospital, Clinical Research Center, Boston, United States) M Maggie Malsch (1Dana-Farber/Boston Children's Cancer and Blood Disorders Center; Harvard Medical School, Boston, United States) K Kasiani Myers (1Cincinnati Children's Hospital Medical Center, Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati, United States) A Akiko Shimamura (Dana Farber/Boston Children's Cancer and Blood Disorders Center; Harvard Medical School, Boston, Massachusetts, United States)

Abstract

Abstract This study identified an increased risk of lymphoid malignancy in Shwachman-Diamond syndrome (SDS) with an observed risk 38-fold higher than expected based on population data. Increased toxicity was observed with standard therapies in patients with SDS.

Article Details

Journal Blood
Volume / Issue Vol. 145, Issue 21
Published May 22, 2025
Pages 2528-2532
ISSN 0006-4971
Publisher Elsevier BV

Journal Info

Blood

Elsevier BV

ISSN: 0006-4971 Health Sciences

Authors (19)

H

Helen D. Reed

1Dana-Farber and Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA

H

Hyunwoo Do

2Biostatistics and Research Design Center, Boston Children’s Hospital, Boston, MA

E

Edie Weller

3Boston Children's Hospital, Boston, United States

M

Marian H. Harris

C

Christopher R. Reilly

H

Harrison K. Tsai

4Department of Pathology, Boston Children’s Hospital, Boston, MA

J

Jason E. Farrar

6Arkansas Children’s Research Institute, Little Rock, AR

B

Bonnie W. Lau

8Department of Pediatrics, Dartmouth Health, Geisel School of Medicine at Dartmouth College, Lebanon, NH

L

Lauren Pommert

7Cincinnati Children's Hospital Medical Center, Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati, United States

C

Christopher Gamper

11Johns Hopkins University School of Medicine, Baltimore, MD

I

Ian Atkinson

1Dana-Farber/Boston Children's Cancer and Blood Disorders Center; Harvard Medical School, Boston, United States

K

Katherine Coyne

1Dana-Farber and Boston Children’s Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA

M

Margret Joos

1Dana-Farber/Boston Children's Cancer and Blood Disorders Center; Harvard Medical School, Boston, United States

S

Sara Loveless

1Cincinnati Children's Hospital Medical Center, Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati, United States

S

Sarah Steltz

4Boston Children's Hospital, Clinical Research Center, Boston, United States

L

Leah Cheng

4Boston Children's Hospital, Clinical Research Center, Boston, United States

M

Maggie Malsch

1Dana-Farber/Boston Children's Cancer and Blood Disorders Center; Harvard Medical School, Boston, United States

K

Kasiani Myers

1Cincinnati Children's Hospital Medical Center, Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati, United States

A

Akiko Shimamura

Dana Farber/Boston Children's Cancer and Blood Disorders Center; Harvard Medical School, Boston, Massachusetts, United States