Maternal <i>Tmprss6</i> is required for hepcidin suppression and fetal health
Abstract
Abstract The antenatal role of the hepcidin-regulating protease Tmprss6 has never been elucidated because knockout dams are infertile. Using an in vivo knockdown approach, we confirm Tmprsss6 is critical for hepcidin suppression in pregnancy, and Tmprss6 inhibition drives deleterious fetal outcomes.
Article Details
Authors (11)
Katherine L. Fielding
1Infection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
Cavan Bennett
1Walter and Eliza Hall Institute of Medical Research, Infection and Global Health, Parkville, Australia
Anne Pettikiriarachchi
Naomi Jones
1Infection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
Rebecca Harding
1Infection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
Alistair R. D. McLean
1Infection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
Louise Randall
1Infection and Global Health Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
Ute Schaeper
4Drug Discovery Department, Silence Therapeutics GmbH, Berlin, Germany
Alberto Martinez
5Department of Clinical Science, Silence Therapeutics PLC, Berlin, Germany
Ricardo Ataide
1Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Sant-Rayn Pasricha