Blood
Articles in this Issue
TP53 mutations in paired bone marrow and cell-free DNA samples of patients with Waldenström macroglobulinemia or IgM monoclonal gammopathy of undetermined significance prospectively enrolled in the FIL_biowm study of fondazione italiana linfomi
Abstract Background. TP53 mutations are emerging as a relevant prognostic and predictive biomarker in Waldenström Macroglobulinemia (WM). In...
Frailty assessed by HCT-FS predicts survival and non-relapse mortality across hematologic disorders undergoing allo-HCT: A multicenter Study of 992 patients
Abstract Introduction: Frailty is an important factor impacting outcomes following allogeneic hematopoietic cell transplantation (allo-HCT)....
Activation of pyruvate kinase by mitapivat potentially rescues ineffective erythropoiesis in models of diamond blackfan anemia.
Abstract Diamond-Blackfan anemia (DBA) is a rare congenital bone marrow failure syndrome, characterized by decreased red blood cell (RBC) pr...
Post-transplant monitoring of multiparameter flow-cytometry (MFC)-based measurable residual disease (MRD) assessment combined with T-cell chimerism following allogeneic stem cell transplantation (HCT) in Acute Myeloid Leukemia (AML) and myelodysplastic syndrome (MDS)
Abstract Introduction Post-transplant surveillance using measurable residual disease (MRD) and donor chimerism provides critical information...
CBFA2T3::GLIS2 directly represses differentiation and is required for AMKL disease maintenance
Abstract Acute megakaryoblastic leukemia (AMKL) is a rare form of AML that largely affects infants and toddlers. Among the most aggressive s...
Mitoxantrone hydrochloride liposome-based CMOP±R regimen achieves superior response in treatment-Naïve non-Hodgkin lymphoma: A phase III clinical trial with matching-adjusted indirect comparison
Abstract Background: Non-Hodgkin lymphoma (NHL) represents a heterogeneous group of malignancies originating from lymph nodes and lymphoid t...
Long term effect of marstacimab prophylaxis in hemophilia Α and Β on target joints: Results from BASIS and OLE studies
Abstract Background: Marstacimab is a tissue factor pathway inhibitor (TFPI) antagonist recently approved for prophylactic treatment of hemo...
Predictors of survival with and without allogeneic stem cell transplantation after first salvage therapy with blinatumomab and/or inotuzumab ozogamicin for Relapsed/Refractory B-cell acute lymphoblastic leukemia
Abstract Background: B-cell–directed targeted agents, including blinatumomab (blina) and inotuzumab ozogamicin (InO), have improved outcomes...
Results of the primary end-point of the LOC-R01: A randomized phase II Study of lenalidomide and ibrutinib in association with rituximab-methotrexate procarbazine vincristin (R-MPV) as a targeted induction treatment for patients aged 18 to 65 with a newly diagnosed primary central nervous system lymphoma (PCNSL)
Abstract BACKGROUND With standard high-dose methotrexate (HDMTX) and cytarabine (HDAraC)-based inductions, half of the patients achieved comp...
A functional precision medicine clinical trial in Relapsed/Refractory multiple myeloma: Prospective study of a high throughput drug sensitivity assay on correlation of drug sensitivity scores with treatment response
Abstract Introduction: Relapsed Multiple Myeloma (MM) is a genetically heterogeneous malignancy characterized by variable treatment response...
CD27, CD62L and ESAM define a multipotent progenitor population with megakaryocytic potential
Abstract Background:How hematopoietic lineage specification occurs is a long-standing question, with major implications for disease developm...
Trends and disparities in mortality among patients with anemia and sepsis in the United States from 1999 to 2023: A CDC wonder database analysis
Abstract Introduction: Anemia and sepsis are interrelated and significant contributors to morbidity and mortality in the United States, espe...
Real-world treatment patterns and patient characteristics of venetoclax combination time-limited therapy for chronic lymphocytic leukemia
Abstract Background The use of targeted therapies, such as combinations of anti-CD20 monoclonal antibodies and BCL2 inhibitors, is rapidly e...
Short-term IL-21 and GSK-3β inhibition enriches stem-like CD8⁺ T cells and boosts CD19 CAR T-cell effector function
Abstract The success of adoptive cell transfer therapy (ACT) hinges on T cell quality, particularly differentiation state, which governs in...
Selinexor in combination with venetoclax and azacitidine for newly diagnosed (ND) unfit Acute Myeloid Leukemia (AML): A multicenter, open-label prospective study
Abstract Introduction： The triple regimen of selinexor, venetoclax, and azacytidine (SAV) has demonstrated favorable results in AML patient...
Fungal infections following chimeric antigen receptor T-cell (CAR-T) cell therapy: A retrospective case-control study in the south-central US
Abstract Background: Patients receiving chimeric antigen receptor T-cell (CAR-T) therapy are at increased risk for infec...
Efficient, potent, and specific near-universal base and prime editing for ELANE-mutant severe congenital neutropenia
Abstract Severe congenital neutropenia (SCN) is a life-threatening disorder of neutrophil production most frequently caused by dominant muta...
Golseek-1: A Phase 3, double-blind, randomized study of golcadomide (GOLCA), a potential, first-in-class, oral CELMoD™ agent, + R-CHOP vs placebo + R-CHOP in patients with previously untreated, high-risk, large B-cell lymphoma
Abstract Background and Significance Diffuse large B-cell lymphoma (DLBCL) and other LBCLs account for 35–40% of non-Hodgkin lymphoma cases i...
Jagged-1+ damage-resistant myeloid progenitors initiate the recovery of the bone marrow endothelial-niche
Abstract Combined chemotherapy and irradiation is a well-established preconditioning treatment to ensure the engraftment of healthy hematopo...
IPSS-m outperforms IPSS-R in younger adults with Myelodysplastic Syndromes: A retrospective age-stratified analysis
Abstract Introduction Myelodysplastic syndromes (MDS) predominantly affect older adults, with a median age at diagnosis...
Comparative outcomes of adult T-cell leukemia/lymphoma in academic and community cancer programs
Abstract Background: Adult T-cell leukemia/lymphoma (ATL) is an aggressive malignancy of mature CD4+ T-lymphocytes. It is associated with in...
From response to rupture: Evaluating GI perforation after CD19 CAR‑T in LBCL
Abstract Introduction: CD19-directed chimeric antigen receptor T (CAR-T) cell therapy has dramatically improved outcomes...
Golcadomide demonstrates potent antiproliferative activity in T-cell lymphoma via degradation of IKZF1 and IKZF3
Abstract T-cell lymphomas (TCLs) are a heterogeneous group of aggressive non-Hodgkin lymphomas characterized by poor prognosis and limited t...
A phase 1/2a trial of amsulostat, a novel pan-lysyl oxidase inhibitor, in patients with advanced myelofibrosis as an add-on to ruxolitinib treatment for up to 52 weeks
Abstract Background Myelofibrosis (MF) is associated with elevated expression of lysyl oxidases, a family of enzymes responsible for maturat...
Lineage-specific distribution of clonal hematopoiesis of indeterminate potential across mature hematopoietic subpopulations in cancer patients
Abstract INTRODUCTIONThe mechanism by which CHIP arises and skews hematopoietic differentiation toward specific blood cell lineages remains...