Uncovering the genomic complexity of <i>PAX5</i> intragenic tandem multiplication via long-read and short-read sequencing
Abstract
Abstract By integrating short-read whole-genome sequencing and RNA sequencing (RNA-seq) data with long-read RNA-seq, we dissect the complex genomic architecture of PAX5 intragenic tandem multiplication, revealing that these complex rearrangements result in in-frame transcripts that likely encode proteins with altered domains.
Article Details
Authors (35)
Yanling Liu
Bensheng Ju
Li Dong
Melanie Loyd
2Hartwell Center for Biotechnology, St. Jude Children’s Research Hospital, Memphis, TN
Samuel W. Brady
Rhonda Ries
Yuan Feng
Heather Mulder
Emily Plyler
Christian Deardorff
5Nationwide Children’s Hospital, Columbus, OH
Andrea McBride
5Nationwide Children’s Hospital, Columbus, OH
Tyler Jones
Alexis Eckert
5Nationwide Children’s Hospital, Columbus, OH
Pandurang Kolekar
1Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN
Li Fan
Hanxia Li
1Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN
Monta Brīvība
Huanbin Zhao
Declan Bennett
Geoff Neale
2Hartwell Center for Biotechnology, St. Jude Children’s Research Hospital, Memphis, TN
Ti-Cheng Chang
Wenan Chen
Stanley Pounds
Gang Wu
Charles Mullighan
9Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN
Paul Geeleher
Lingyun Ji
Jun J. Yang
Department of Pharmacy and Pharmaceutical Sciences
Soheil Meshinchi
Patrick A. Brown
11BeOne Medicines, Cambridge, MA
William L. Carroll
12Department of Pediatrics, NYU Langone Health, New York, NY
Jinghui Zhang
Mignon L. Loh
Seattle Children’s Hospital, Seattle
John Easton
Xiaotu Ma
1Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN