Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics
Abstract
Abstract We have developed a cost-effective DNA methylation sequencing assay to improve monitoring of clonal hematopoiesis. By inferring cell-type proportions, this method enhances interpretation of clonal trajectories compared with interpretation based on variant allele fraction only.
Article Details
Authors (10)
Alyssa C. Parker
1Program in Human Genetics, Vanderbilt Genetics Institute, Vanderbilt University School of Medicine, Nashville, TN
Joseph C. Van Amburg
J. Brett Heimlich
3Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
Yash Pershad
Nicole A. Mickels
2Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
Taralynn M. Mack
P. Brent Ferrell
7Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
Michael R. Savona
Department of Internal Medicine, Vanderbilt University School of Medicine
Angela L. Jones
6Vanderbilt Technologies for Advanced Genomics, Vanderbilt University Medical Center, Nashville, TN
Alexander G. Bick