<i>DNMT3A</i> mutations are unlikely to affect interferon alfa treatment outcomes in patients with polycythemia vera

G Ghaith Abu-Zeinah (1Weill Cornell Medicine, New york city, United States) K Katie Erdos (2Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, United States) N Neville Lee (2Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, United States) Y Yara Ganom (1Division of Hematology and Medical Oncology, Richard T. Silver MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY) C Christoph Klade (38AOP Health, Vienna, Austria) K Kurt Krejcy (38AOP Health, Vienna, Austria) H Heinz Gisslinger (8Medical University of Vienna, Vienna, Austria) R Richard T. Silver (1Division of Hematology and Medical Oncology, Richard T. Silver MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY) J Joseph M. Scandura (1Division of Hematology and Medical Oncology, Richard T. Silver MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY)

Abstract

Abstract DNMT3A mutations in patients with polycythemia vera were heterogeneous and not enriched in interferon alfa–treated patients. DNMT3A mutations had no detectable impact on the hematologic response, molecular response, or survival outcomes.

Article Details

Journal Blood
Volume / Issue Vol. 146, Issue 1
Published July 03, 2025
Pages 123-126
ISSN 0006-4971
Publisher Elsevier BV

Journal Info

Blood

Elsevier BV

ISSN: 0006-4971 Health Sciences

Authors (9)

G

Ghaith Abu-Zeinah

1Weill Cornell Medicine, New york city, United States

K

Katie Erdos

2Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, United States

N

Neville Lee

2Richard T. Silver, MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, United States

Y

Yara Ganom

1Division of Hematology and Medical Oncology, Richard T. Silver MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY

C

Christoph Klade

38AOP Health, Vienna, Austria

K

Kurt Krejcy

38AOP Health, Vienna, Austria

H

Heinz Gisslinger

8Medical University of Vienna, Vienna, Austria

R

Richard T. Silver

1Division of Hematology and Medical Oncology, Richard T. Silver MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY

J

Joseph M. Scandura

1Division of Hematology and Medical Oncology, Richard T. Silver MD Myeloproliferative Neoplasms Center, Weill Cornell Medicine, New York, NY