Introduction to a review series on the structural underpinnings of hemostatic plugs and thrombotic occlusions

Abstract

Structure and function are the 2 critical knowledge elements that must be combined for complex systems such as occlusive thrombus formation to be understood. Edited by Associate Editor Thomas L. Ortel, this review series focuses on recent advances in resolving macro and molecular structures that have driven the field forward. Covering multiple contributions to thrombosis, eg, platelets, factor XIII, and the contact system, the series also looks to put this new knowledge into the context of future advances in diagnostic and therapeutic tools to enhance normal hemostasis while preventing and treating unwanted thrombosis.