Utility of peripheral blood testing for detection and surveillance of clonal hematopoiesis in predisposed individuals
Abstract
Abstract In this study, 108 pediatric patients with bone marrow (BM) failure and leukemia predisposition were evaluated for presence of clonal hematopoiesis in peripheral blood (PB) and BM. Robust PB-BM concordance for mutations but decreased sensitivity in PB for chromosomal abnormalities was found.
Article Details
Authors (22)
Enrico Attardi
1Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
Nathan Gray
1Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN
Sara Lewis
Michelle Boals
1Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
Passant Shaker
1Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
Lili Kotmayer
1Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
Sushree S. Sahoo
1Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN
Peng Li
Erica F. Andersen
3Department of Pathology, ARUP Laboratories, University of Utah, Salt Lake City, UT
Jian Zhao
Lucilla Pizzo
3Department of Pathology, ARUP Laboratories, University of Utah, Salt Lake City, UT
Joseph H. Oved
2Pediatric Transplant and Cellular Therapy Service, Memorial Sloan Kettering Kids, Memorial Sloan Kettering Cancer Center, New York, NY
Rohith Jesudas
1Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
Ulrike M. Reiss
Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN
Richa Sharma
Georgios E. Christakopoulos
1Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
Senthil Velan Bhoopalan
Clifford M. Takemoto
3Department of Hematology, St. Jude Children’s Research Hospital, Memphis, TN
Alyssa Kennedy
1Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN
Maria Teresa Voso
Guolian Kang
Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN
Marcin W. Wlodarski