Angewandte Chemie International Edition
Articles in this Issue
Stepwise Conjugation Extension of Covalent Organic Frameworks via Multicomponent Linkage Conversion for Optimized Photocatalytic Molecular Oxygen Activation
ABSTRACT Conjugated covalent organic frameworks (COFs) have emerged as a promising class of semiconducting heterogeneous photocatalysts. Precise control of the conjugation within the...
Zwitterionic Gel Electrolyte Stabilized Multivalent Tellurium Redox for High‐Energy Lithium Batteries
ABSTRACT Lithium batteries based on multivalent chalcogen conversion chemistries offer a promising route toward high‐energy, practical energy storage, but their...
Organocatalytic Enantioselective Addition of Malonates to Cyclic Imines: A Short Total Synthesis of Tetraponerine T‐1
ABSTRACT Cyclic imines are common intermediates in the biosynthesis of alkaloids, but their use in enantioselective organic synthesis is limited by their high reactivity and tendency...
Synthesis of Six Natural Products Enabled by Selective Hydroxylation of Orcinaldehyde‐Like Substrates With an Enzyme Library
ABSTRACT Achieving selective oxygenation chemistry offers a powerful strategy for streamlining routes to complex target molecules, yet the development of site‐selective C–H functiona...
T‐Shaped Stibenium(III) Cation: Hydrostibination Without Sb─H Bond
ABSTRACT The hydrostibination of alkenes represents a largely underdeveloped transformation, owing to the intrinsic lability of the required Sb─H reagents. We no...
Strain Effect Triggers Pt Adaptive Mechanism to Construct Brønsted Acid Microenvironment for Ampere‐Level Hydrogen Production From Alkaline Seawater
ABSTRACT Intermittent renewable energy‐driven seawater hydrogen production can alleviate freshwater resource pressure and is of great significance in future ener...
Visible Light‐Driven Copper‐Catalyzed Asymmetric Synthesis via Sequential C(sp <sup>3</sup> )─C(sp <sup>3</sup> ) Bond Scission
ABSTRACT The selective and consecutive cleavage of C(sp 3 )─C(sp 3 ) bonds while...
Interfacial Entropy Drives Crystallization of Covalent Framework Membranes for Precise Ionic Separation
ABSTRACT Achieving highly crystalline covalent organic framework (COF) membranes is essential for efficient mass transport but remains a longstanding challenge d...
Atomically Precise NHC‐Protected Alkylgold Nanoclusters
ABSTRACT Alkylgold complexes are of paramount significance in organometallic chemistry owing to their catalytic relevance, yet atomically precise alkylgold(0) sp...
Modulating the Electron Mediators for Spatially Separated H <sub>2</sub> and O <sub>2</sub> Evolutions in Photocatalytic Water Splitting
ABSTRACT A fundamental obstacle in photocatalytic overall water splitting lies in the simultaneous evolution of H 2 and O...
Lewis Acid/Base Au–Mn Pairs in Metal Nanoclusters for Enhanced Photocatalytic C(sp <sup>2</sup> )–H Arylation
ABSTRACT Integrating polar bimetallic active sites on the metal nanocatalysts for advanced cross‐coupling reactions holds great promise, yet is challenging. Here...
Operando Electrochemical Phase Engineering Overcomes Activity–Stability Trade‐Off in Perovskite Electrocatalysts
ABSTRACT Electrocatalysts for diverse electrochemical devices commonly suffer from a trade‐off between activity and stability, as highly active surface features...
Unlocking Interfacial Binder Chemistry for Efficient Li <sup>+</sup> Desolvation in 3C‐Rate Lithium Metal Pouch Cells
ABSTRACT Lithium‐ion transport dynamics at the cathode electrolyte interface play a crucial role in determining the performance of lithium batteries. However, mo...
Proteome‐Wide Target Identification Using Reactive Metallo‐Scaffolds ( <i>r</i> ‐mS): A Platform for Metallodrug Discovery
ABSTRACT Metal complexes offer unique opportunities as scaffolds in chemical biology and drug discovery, with tunable geometries, modular coordination environmen...
Minute‐Scale Repeated Metabolic Probing of Living Cells Enabled by Rapid Parahydrogen‐Based Hyperpolarization
ABSTRACT Hyperpolarized (HP) 13 C nuclear magnetic resonance (NMR) spectroscopy enables real‐time observation of metaboli...
Deep Learning Enables Identification of Antimicrobial Peptides Through Mechanochromic Fingerprints
ABSTRACT Antimicrobial peptides (AMPs) are promising antibiotic alternatives, but their diverse modes of action make functional classification slow and labor‐intensive. Here we intro...
Selective Electrosynthesis of High‐Concentration Mn <sup>IV</sup> ═O in Oxidant‐Free Systems for Sustainable Water Remediation
ABSTRACT High‐valent metal‐oxo (HVMO) exhibit selective oxidation properties, but their selective synthesis and high‐concentration aggregation remain challenging...
Anchoring‐Induced Interphase via Dual Mortise‐Tenon Interactions for Synergistic Stabilization of Surface Co and O in High‐Voltage LiCoO <sub>2</sub> Cathodes
ABSTRACT Interfacial instability of LiCoO 2 (LCO) above 4.6 V remains a bottleneck for high‐energy‐density batteries due...
Underexplored Catalysts as General Structures: Application of Machine Learning Techniques for Reaction‐Specific Datasets
ABSTRACT General catalysts are usually identified through broad experimental screening to find structures that perform reliably across many substrates and reaction classes. In second...
Dual‐Boron Multi‐Resonance Thermally Activated Delayed Fluorescence Emitters Based on Spirofluorene‐Rigidified Indolocarbazole for Ultra‐Narrowband Luminescence
ABSTRACT Multi‐resonance thermally activated delayed fluorescence (MR‐TADF) emitters are a research focus for organic light‐emitting diodes (OLEDs) targeting ult...
Conversion of Alkenes Into Simple or Functionalized Aldehydes by Reaction With an Ambiphilic Masked Formyl Radical
ABSTRACT The synthetic application of formyl radicals and other masked formyl radicals is constrained by their weak electrophilicity ( ω...
Photochemical Cascade Nitrile Activation via a Carbene‐Nitrene Relay
ABSTRACT The deliberate integration of reactive intermediates into programmed bond‐forming sequences represents a powerful approach for advancing organic synthes...
Construction of a Glutathione‐Gated Intelligent Nanoclassifier for Spatioselective Visualization of Dual CircRNAs and Synergistic Photodynamic Therapy
ABSTRACT Circular RNAs (circRNAs) are key endogenous regulators of tumorigenesis and progression, and their high interspecies diversity and strong sequence homol...
Central Core Engineering of Aromatic Carbonyl Molecules Enables Highly Efficient and Stable Perovskite Solar Cells
ABSTRACT Aromatic carbonyl molecules have emerged as highly effective passivation additives for fabricating efficient and stable perovskite solar cells. However,...
Tunable Synthesis of Multi‐Responsive NH‐Containing Helical Nanographenes With a Chiroptical Switching Function
ABSTRACT Helical nanographenes (HNGs) have attracted much attention owing to their red‐region chiroptical properties. These HNGs, typically based on hexa‐peri‐hexabenzocoronene (HBC)...