Angewandte Chemie International Edition

Leaflet‐Specific Structure and Dynamics of Solid and Polymer Supported Lipid Bilayers

AbstractPolymer‐supported or tethered lipid bilayers serve as versatile platforms for mimicking plasma membrane structure and dynamics, yet the impact of polymer supports on lipid bilayers remains lar...

Inter‐Site Distance Effect in Electrocatalysis

AbstractThe inter‐site distance effect (ISDE) has gained significant attention in heterogeneous catalysis, challenging classical models that treat adjacent nonbonded sites as isolated. Recent studies...

Convergent Assembly of Homo‐ and Heterotypic Ubiquitin Chains from Functionalized, Expressed Monomers via Thiol‐Ene Chemistry

AbstractNature constructs ubiquitin tags with high spatiotemporal precision to execute defined functions that critically rely on the exact molecular composition of the ubiquitin chain. Deciphering the...

Simultaneous Activation of Bicyclobutanes and Indolyl Alcohols with HFIP: Access to Indole‐Fused Bicyclo[3.1.1]Heptanes

AbstractThe concept of strain release to unleash unique reactivity that drives a wide range of synthetically valuable transformations has long intrigued chemists. Among the various strained systems, h...

Immunoengineering of a Photocaged 5´‐triphosphate Oligoribonucleotide Ligand for Spatiotemporal Control of RIG‐I Activation in Cancer

AbstractPhotochemical control of oligonucleotides bears great potential for the spatio‐temporal control of therapeutic targets, such as immune sensing receptors. Retinoic acid‐inducible gene I (RIG‐I)...

Competition between One‐ and Two‐Electron Unimolecular Reactions of Late 3d‐Metal Complexes [(Me₃SiCH₂)<i>_n</i>M]^–(M = Fe, Co, Ni, and Cu; <i>n</i> = 2–4)

AbstractAlthough organometallic complexes of the late 3d elements are known to undergo both one‐and two‐electron reactions, their relative propensities to do so remain poorly understood. To gain direc...

Molecule Differentiation Encoding Microscopy to Dissect Dense Biomolecules in Cellular Nanoenvironments below Spatial Resolution

AbstractCellular biomolecules may exhibit dense distribution and organization at the nanoscale to govern vital biological processes. However, it remains a common challenge to digitize the spatially de...

Transaminase‐Triggered Cascades for the Synthesis and Dynamic Kinetic Resolution of Chiral <i>N</i>‐Heterocycles

AbstractBiocatalysis is now a well‐established branch of catalysis and the growing toolbox of natural, evolved and designer enzymes is enabling chemistry previously deemed inaccessible. However, most...

Front Cover: Halogen Bonding as a Tool to Control Morphology and Charge (Angew. Chem. Int. Ed. 21/2025)

Inside Front Cover: Exploring the Mechanism of Surface Cationic Vacancy Induces High Activity of Metastable Lattice Oxygen in Li‐ and Mn‐Rich Cathode Materials (Angew. Chem. Int. Ed. 21/2025)

Frontispiece: pH‐Dependent Switching Between Nonlinear‐Optical‐Active Nitrate‐Based Supramolecular Polymorphs

Capturing Unstable Carbanionic Intermediates via Halogen Transfer: Base‐Promoted Oxidative Coupling Reactions of α,α‐Difluoromethylarenes

AbstractWe describe how the merger of deprotonation, halogenation, and substitution into compatible processes enables the productive functionalization of traditionally unstable carbanionic intermediat...

Fast Sodium Ion Conductivity in Pristine Na₈SnP₄: Synthesis, Structure and Properties of the Two Polymorphs LT‐Na₈SnP₄ and HT‐Na₈SnP₄

AbstractAchieving high ionic conductivities in solid state electrolytes is crucial for the development of efficient all‐solid‐state‐batteries. Considering future availability and sustainability, sodiu...

Identification, Characterization, and Catalytic Mechanism of Regioselective UbiA Prenyltransferases in <i>Morus</i> Plants

AbstractUbiA prenyltransferases (PTs) play an indispensable role in the prenylation of plant metabolites, yielding numerous natural products with enhanced pharmacological activities, such as cannabino...

Allenylidene Phosphonium Ion: An Isoelectronic Phosphorus Analogue of [3]Cumulene

AbstractHerein, we disclose the synthesis, characterization, and bonding analysis of a crystalline allenylidene phosphonium ion ([R2P═C═C═CAr2]+) [2]+ (R = 1,3‐diisopropylphenylimidazolin‐2‐ylidenamin...

Indirect Anti‐Markovnikov Hydrofunctionalization of Terminal Alkenes via an Alkenyl Thianthrenium Intermediate

AbstractThe anti‐Markovnikov hydrofunctionalization of terminal, unactivated olefins is an evergreen synthetic challenge in organic chemistry. Several direct and indirect anti‐Markovnikov methods have...

Chularat Wattanakit

Sarah Guerin

Understanding and Tuning Singlet–Triplet (S₁–T₁) Energy Gaps in Planar Organic Chromophores

AbstractMolecules with large gaps between their first singlet and triplet excited states (ΔEST) are key components of various modern technologies, most prominently singlet fission photovoltaics and tr...