Angewandte Chemie International Edition
Articles in this Issue
Predicting the Stability of Base‐mediated C─H Carboxylation Adducts Using Data Science Tools
Abstract Base‐mediated C–H carboxylation is a versatile pathway for utilizing carbon dioxide (CO 2 ) as a C1 building blo...
Bioinspired Synthesis of Twin <i>abeo</i> ‐Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction
Abstract This manuscript describes a concise bioinspired synthesis of twin abeo ‐steroids bufogargarizins A and B with an...
Harnessing Hydrogen Cyanide (HCN): Responsive Chemical Tools for Delivering an Emerging Gasotransmitter
Abstract Hydrogen cyanide (HCN) is an emerging gasotransmitter, joining NO, CO, and H 2 S in a group of important endogen...
Cost‐Effective Schiff‐Base Nickel Complexes as Cathode Interlayers for High‐Efficiency Organic Solar Cells
Abstract Efficient cathode interlayers (CILs) materials are crucial for high performance bulk‐heterojunction organic solar cells (BHJ‐OSCs). Herein, we report th...
Fragmentation of Isoxazolones to Alkynes Enabled by Anomeric Amides
Abstract Over the past few years, isodiazenes have reemerged as an important class of intermediates with substantial synthetic potential. The most direct route t...
Asymmetric Synthesis of P(V) Skeleton via Catalytic Desymmetric Substitution
Abstract Stereogenic‐at‐P(V) skeletons exist ubiquitously in drugs, agrochemicals, organocatalysts, ligands and materials. Conventional synthetic methods mainly rely on chromatograph...
Oxygen‐Incorporation‐Engineered Interfacial Water Modulation on Single‐Atom Cu Sites for Enhanced Dilute Nitrate Electroreduction
Abstract The efficiency of nitrate reduction reaction (NO 3 RR) is highly dependent on the complex interfacial microenvir...
Biodegradable Nano‐Regulator Reprograms Glioblastoma Immunosuppression: Pyroptosis‐Metabolism‐Immunity Crosstalk for Cascading Immune Activation
Abstract Glioblastoma's (GBM) resistance to immunotherapy is primarily attributed to its immunosuppressive tumor microenvironments (TME), characterized by metabo...
Time‐Resolved SAXS Studies During the Synthesis of Hydrolytically Degradable Poly(ε‐caprolactone)‐Poly( <i>N,N′</i> ‐dimethylacrylamide) Diblock Copolymer Nanoparticles in Aqueous Media
Abstract The mechanism of nanoparticle formation during reverse sequence polymerization‐induced self‐assembly (PISA) is s...
Carbonyl‐to‐Silicon Exchange of Aromatic Lactones via Decarbonylation
Abstract Sila substitution, the strategy of replacing a specific carbon atom in organic molecules with silicon has garnered significant interest for the development of new functional...
Large‐Area COF Membrane with Hourglass‐Shaped Nanochannels for Enhanced Hydrogen Separation
Abstract Efficient hydrogen purification from methanol steam reforming (MSR) faces challenges due to H 2 /CO...
Enantioconvergent Access to Chiral S(VI) Stereocenters by Kinetic Resolution of Sulfonimidoyl Chlorides
Abstract Sulfur chirality has recently gained in importance across a wide range of chemical domains. However, the dearth of catalytic approaches for sulfur(VI) stereocenters continue...
Co‐Assemblies Regulate the Catalytic Activity of Peptide Fibrils
Abstract Short peptide sequences self‐assemble into supramolecular structures through intermolecular interactions, creating a microenvironment in which chemical reactions can be cata...
All‐in‐One Molecule Regulated Buried Interface and Crystallization of Tin–Lead Perovskite for Efficient All‐Perovskite Tandem Solar Cells
Abstract Mixed tin–lead (Sn–Pb) perovskite solar cells (PSCs) are critical for advancing all–perovskite tandem solar technologies, as they resolve the efficiency limitations of singl...
Inside Back Cover: Tailored Core‐Shell Nanocarrier for Therapeutic Drug Delivery via Visible Light Activation (Angew. Chem. Int. Ed. 2/2026)
Dual Proton/Anion Binding Through Reciprocal Allostery in Platinum(II) Lantern‐Shaped Cages
Abstract Reciprocal allosteric regulation, where binding events influence each other simultaneously, is a key target for supramolecular chemists designing biomimetic systems. Platinu...
Fluorescent Probes Derived from the Polyene Class of Antifungal Drugs Reveal Distinct Localization Patterns and Resistance‐Associated Vacuolar Sequestration in <i>Candida</i> Species
Abstract Amphotericin B, nystatin, and natamycin are the only polyene antifungals in clinical use and remain last‐resort therapies for severe fungal infections....
Tuning Polyacrylate Composition to Recognize and Modulate Fluorescent Proteins
Abstract Molecular definition is usually regarded as a prerequisite to achieve protein recognition and functional modulation, particularly for macromolecular interactions. Herein, we...
Triply Responsive Control of Ion Transport with an Artificial Channel Creates a Switchable AND to OR Logic Gate
Abstract Ion channels are ubiquitous in Nature, performing complex and essential tasks in our bodies. Synthetic chemists have begun to understand how to form art...
Boosting Nitrate Reduction through Ru‐CO <sub>3</sub> <sup>2−</sup> Microenvironment Modulated Hydrogen‐Bond Networks
Abstract Electrocatalytic reduction of nitrate (NO 3 − )‐rich wastewater to ammonia (NH...
Design of a Multienzyme Derived from Mouse Fatty Acid Synthase for the Compartmentalized Production of 2‐Pyrone Polyketides
Abstract Compartmentalizing biosynthetic pathways is a key objective in protein engineering, particularly in synthetic biology and metabolic engineering. It can...
Surface Halide Inversion Mitigates Voltage Losses in Wide‐Bandgap Perovskite for Efficient Tandem
Abstract Substantial energy loss at the wide‐bandgap (WBG) perovskite/fullerene interface poses a fundamental bottleneck for efficient all‐perovskite tandem sola...
Frame‐Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design
Abstract Chemists continue to develop strategies that leverage abundant feedstocks to accelerate the production of medicines, agrochemicals, and materials. Oligoheterocycles are a br...
Cu‐Catalyzed Aerobic Oxidative C─C Cleavage in Lignin‐Derived Oligomers and Biological Funneling of the Monomeric Products
Abstract Existing methods for lignin deconstruction to aromatic monomers primarily cleave carbon–oxygen bonds within the polymer, resulting in sub‐optimal monome...
Halogen Co‐Mixing—An Effective Strategy for Optimizing Luminescent Performance of Copper‐Based Hybrid Scintillator
Abstract Recently, copper‐based hybrid scintillators have emerged as a popular research area. However, its development remains in its infancy, and there is an ur...