Angewandte Chemie International Edition
Articles in this Issue
Extended Endocyclic Conjugation and <i>N,N</i> ‐Bidentate Chelation Alleviate the Capacity–Stability Trade‐Off in Organic Magnesium Battery Cathodes
ABSTRACT Rechargeable Mg batteries represent an appealing post‐lithium energy‐storage technology, yet their advancement is hampered by the scarcity of cathode ma...
A Molecular Trimming Strategy for Hypoxia‐Tolerant Photosensitizers With Enhanced cGAS‐STING Activation
ABSTRACT The development of effective photosensitizers for photo‐immunotherapy is highly desirable yet remains challenging, particularly given the prevailing rel...
In Situ Synchronized SERS‐SEIRAS Unveils Cation‐Regulated Interfacial Water and Intermediates in the Oxygen Reduction Reaction
ABSTRACT Interfacial water plays a crucial yet poorly understood role in the alkaline oxygen reduction reaction (ORR) by modulating the adsorption of oxygen inte...
Interfacial Proton Ordering Near the Electrode Surface Directs Carbonyl Electroreduction to Methylene
ABSTRACT Carbonyl‐to‐methylene deoxygenation is a fundamental transformation in organic synthesis, but conventional Clemmensen and Wolff–Kishner–Huang reductions require harsh acidic...
Precise Regulation of Intrachannel Negative Charge Density in Metal‐Organic Frameworks for Efficient Alkali‐Ion Transport
ABSTRACT Charged nanochannels are critical for efficient cation transport in metal‐organic frameworks (MOFs); however, the relationship between intrachannel nega...
Fibroblast‐Mimetic Lignin Polymersomes for Logic‐Gated Synthesis of Mechanically Reconfigurable Bioskins
ABSTRACT Ageing is inevitable and accompanied by progressive loss of skin elasticity. Fibroblasts, embedded within the extracellular matrix, finely regulate skin mechanics via membra...
Interfacial Electronic Modulation Redirects Anodic Radical Chemistry for Selective C─C Bond Cleavage in Electro‐Oxidative Lignin Depolymerization
ABSTRACT Electro‐oxidative lignin depolymerization is considered a promising route to renewable aromatics; however, its selectivity is often limited by competiti...
Beyond Fluorination: A Golden Criterion Guided by Chemical Coordination‐Informed Machine Learning for High‐Voltage Electrolyte Design
ABSTRACT Fluorine chemistry has garnered attention for extending operating voltage limits of electrolytes through robust interfacial passivation owing to fluorin...
Multicomponent Stapling of Glucagon‐Like Peptide‐1 Enables Receptor‐Guided PROTAC Delivery
ABSTRACT Achieving cell‐selective targeted protein degradation remains a major challenge for translating proteolysis‐targeting chimeras (PROTACs) into therapeutics. Although pancreat...
Single Crystals of Double‐Stranded, Entwined, Helical Metallopolymers With Hexanuclear Zirconium Knots Achieved by Linker Conformation Engineering
ABSTRACT Synthetic one‐dimensional (1D) helical polymers are an intriguing class of functional materials that have been pursued for decades. Despite numerous rep...
Rhodium(III)‐Catalyzed Asymmetric Synthesis of Silanes and Cyclopropanes From Diazo Compounds Using Chiral <i>α</i> ‐Pinene‐Derived Indenyl Ligands
ABSTRACT Rhodium‐catalyzed asymmetric organic reactions are efficient tools for the synthesis of pharmaceuticals and natural compounds, but the search for readil...
Design Guidelines for Anode Modifications to Eliminate Soft Short Circuits in Anode‐Free Na Batteries Under High Current Density With Large‐Capacity Plating, Demonstrated via Initiated Chemical Vapor Deposition (iCVD)
ABSTRACT Soft short circuits, an underrecognized failure mode, are especially critical in anode‐free sodium systems, where limited Na inventory makes cells highl...
A Cholesterol Analogue for Cell‐Surface Enzyme Display
ABSTRACT The cell membrane is a prime target for the introduction of novel cellular functionalities, as it is a complex system with many routes for surface modif...
High‐Entropy Catalyst Activated Molecular Oxygen for Oxidative Coupling Under Ambient Conditions
ABSTRACT Molecular oxygen (O 2 ) activation to generate reactive oxygen species (ROS) underpins catalytic oxidative coupl...
Nucleophilic Gallyl Anions Enable Ga─Au Bimetallic Ammonia Activation
ABSTRACT Controlling the reactivity of low‐valent main‐group nucleophiles in small‐molecule activation remains a significant challenge. Here, we report the synth...
Ultrafast Anion‐Hopping Conduction in Organic Solvent via Imidazolium‐Grafted Dynamic Ion‐Conducting Spacers for Stable Non‐Aqueous Flow Batteries
ABSTRACT Non‐aqueous flow batteries (NAFBs) require membranes with superior organic solvent resistance and high ionic conductivity in organic solvents to endure...