Angewandte Chemie International Edition
Articles in this Issue
A Diffusion‐Retarded Strategy for Practical Zn–I <sub>2</sub> Batteries Under Harsh Conditions
Abstract Zinc–iodine (Zn–I 2 ) batteries attract increasing attention for inherent safety and cost‐effectiveness. However...
Boosting Reversible Photocontrol of a Photoxenase by an Engineered Conformational Shift
Abstract Our study successfully explores strategies to effectively improve the photocontrol efficiency of light‐sensitive enzymes, dubbed photoxenases, with phot...
Photocatalyzed Ring Expansion of α‐Ketosulfonylaziridines: Ready Access to δ‐Sultams
Abstract Herein, a novel photocatalytic ring expansion reaction of aziridines to δ‐sultams through intramolecular radical cyclization is reported. In particular,...
Packing Order Control in Conductive Metal–Organic Frameworks by Tuning Ligand Oxidation State
Abstract Conductive metal–organic frameworks (c‐MOFs), composed of metal nodes and redox‐active ligands, have attracted growing interest due to the coexistence o...
Lattice Strain in Multi‐Component Covalent Organic Frameworks for Enhanced H <sub>2</sub> O <sub>2</sub> Photosynthesis
Abstract The structural designability of donor–acceptor (D–A) covalent organic frameworks (COFs) makes these systems the promising candidates for photocatalytic...
Water‐Splitting “Without Water”: Splitting of the Crystallised Water of Hydrated Salts
Abstract In contrast to the liquid phase of water, the structural molecular realities of H 2 O molecules embedded in crys...
On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily
Abstract The sequencing of numerous genomes has led to the identification of open reading frames for millions of enzymes, many of which use unknown substrates. Hence, the identificat...
Thermodynamic Compensation of Surface Hydroxyl Moieties in Reduced Polyoxometalates Translates to Deviations in the Mechanism of Proton–coupled Electron Transfer
Abstract The design of H‐atom transfer catalysts requires the control of redox potential and proton affinity to direct the mechanism, rate, and selectivity of pr...
Photoenzymatic Aliphatic C─Br Activation for Enantioselective Synthesis of γ‐Stereogenic Nitriles from Alkenes
Abstract Enzymatic strategies for direct cyano group incorporation remain underdeveloped, creating synthetic bottlenecks for accessing chiral nitrile derivatives in pharmaceuticals a...
A Modularly Integrated Chiral Cavitand
Abstract Rational assembly of multiple molecular building blocks enables functional integration. However, precise construction of complex systems comprising of three or more molecula...
Regulating Solvent Co‐Intercalation in Bi‐Layered Vanadium Oxides for Zinc Batteries by Nanoconfinement Chemistry
Abstract Electrochemical intercalation typically involves ion desolvation at the electrolyte–electrode interface, incurring kinetic limitations and strong ion‐ho...
Ruthenium‐Catalyzed Electrochemical Ketone Hydrogenation to Secondary Alcohols with High Activity and Selectivity Under Ambient Conditions
Abstract Secondary alcohols are indispensable building blocks in the production of fine chemicals, pharmaceuticals, and polymers, yet their conventional synthesi...
Monitoring Enzyme Clustering in a Highly Crystalline Metal–Organic Framework by Small‐Angle Neutron Scattering
Abstract The molecular‐level investigation of enzyme behavior in confined, cell‐free environments is essential to understanding intrinsic properties and optimizi...
Blue–Green–Yellow Thermochromic Fluorescence and Bubble‐Propelled Crystal Motion Driven by Molecular Gear Rotations
Abstract Guest‐release induced responsive behaviors in nonporous organic solvate crystals remain elusive due to the lack of well‐defined diffusion pathways and t...
Promoting Electro‐Hydrogenation of Hydrophobic Benzofuran over Pd‐Based Catalyst in Aqueous Media via Electrolyte Engineering
Abstract The electro‐hydrogenation of benzofuran (BF) has been considered as a promising route for the selective synthesis of 2,3‐dihydrobenzofuran (DHBF), a val...
Amphiphobic Solvent‐Mediated Relay Push‐Escape Strategy for Highly Efficient Lithium‐Metal Batteries
Abstract Lithium‐metal batteries promise high‐energy‐density, wide operating temperature ranges, and fast charging. However, integrating these attributes remains...
Water‐Induced Local Redox Reactions on Individual Ti <sub>3</sub> C <sub>2</sub> T <i> <sub>x</sub> </i> MXene Flakes in Aqueous Environment
Abstract Water at an interface, confined in nanopores or between layers exhibits unique structural and dynamic properties that differ significantly from bulk wat...
Boron Hybridization Engineering for Regulating Room Temperature Phosphorescence
Abstract Organic room temperature phosphorescence (RTP) materials have attracted widespread attention for their potential in both fundamental research and advanc...
Divergent Total Synthesis of Denudatine Alkaloids Cochlearenine, Macrocentrine, Dictizine, 15‐Veratroyl‐17‐Acetyl‐19‐Oxodictizine, and the Proposed Structure of Acochlearine
Abstract The first asymmetric total syntheses of four denudatine alkaloids, cochlearenine, macrocentrine, dictizine, and 15‐veratroyl‐17‐acetyl‐19‐oxodictizine,...
Iodine(I)‐Induced Skeletal Rearrangement of α‐Bicyclobutanyl Alcohols and Amines: A Universal Approach to 2‐Oxabicyclo[2.1.1]hexanes and 2‐Azabicyclo[2.1.1]hexanes
Abstract Bicyclo[1.1.0]butane (BCB) has been widely explored as a scaffold for constructing 3D bioisosteres of benzene, owing to its olefin‐like reactivity and a...
Bifunctional Photoactive Chiral Ligands Enable Visible‐Light‐Induced Nickel‐Catalyzed Enantioselective C−O Coupling
Abstract Asymmetric metallaphotoredox catalysis (AMPC) typically relies on dual catalytic systems that often suffer from incompatibility between the photocatalytic and chiral metal c...
A Unique CYP450 Enzyme Unlocks <i>Antrodia Camphorata</i> Lanostane Triterpenoid Diversity Through Oxidation and Skeletal Rearrangement
Abstract Lanostane triterpenoids, key therapeutic components of medicinal mushrooms, such as rare Antrodia camphorata , f...
Cancer‐Selective Intracellular Polymerization via Acrolein‐Driven Cyclodimerization Cascade
Abstract The intracellular polymerization of synthetic macromolecules presents a unique method for modifying cell behavior, enabling real‐time imaging, and enhan...
Flexible Crown‐Ether Polyimides Break the K <sup>+</sup> /Na <sup>+</sup> Selectivity Barrier in Artificial K <sup>+</sup> Channels
Abstract Natural potassium channels such as KcsA exhibit extraordinary K + /Na +...
<sup>18</sup> F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings
Abstract The development of 18 F‐labelled radiotracers is of vital importance for (pre)clinical positron emission tomogra...