Angewandte Chemie International Edition
Articles in this Issue
Xiaoran Hu
Allosteric Regulation of Photophysics and Binding in Oxazine‐macrocycle Complexes at Single‐molecule Resolution
ABSTRACT Dye‐macrocycle complexes have become invaluable tools for various applications. The mechanisms of complex formation and photophysical changes can be com...
Enzyme‐Like Synthetic Cleft for Light‐Driven Water‐Oxidation Catalysis Via an Oxide Relay Pathway
ABSTRACT Harnessing functional groups in the outer coordination sphere to direct catalytic pathways is characteristic for enzymes, yet rather underexplored for m...
On the Ability of Bismuth to Couple Weakly Coordinating Anions
ABSTRACT Similar to aryldiazonium salts, hypervalent bismuth species have been shown to promote coupling of weakly coordinating anions (WCAs) such as triflate and tetrafluoroborate....
Nickel/Photoredox Dual‐Catalyzed Migratory Reductive C( <i>sp</i> <sup>2</sup> )–H/Si–Cl Cross‐Coupling
ABSTRACT Organosilicon compounds have been extensively utilized in both industry and academia. Transition metal‐catalyzed migratory cross‐coupling involving 1,...
Direct δ‐Lactone Synthesis From Free Alcohols via Photoinduced δ‐C(sp <sup>3</sup> )–H Carbonylation in Flow
ABSTRACT The direct carbonylation of unactivated C(sp 3 )─H bonds remains a fundamental challenge in synthesis. Herein, w...
A Non‐Covalent [4Fe–4S]/[2Fe] Interface in HydF Guides [FeFe]‐Hydrogenase Maturation
ABSTRACT Maturation of [FeFe]‐hydrogenase depends on the HydF maturase, a [4Fe–4S]‐containing scaffold protein that assembles and delivers the organometallic [2F...
Polarity‐Directed Synthesis of an Exfoliable 2D Polyoxometalate‐Based Metal‐Organic Framework for Noble Metal‐Free Alkyne Transfer Semi‐Hydrogenation
ABSTRACT Two‐dimensional polyoxometalate‐based metal–organic frameworks (2D POMOFs) hold great promise for catalysis, yet their directed synthesis and facile exf...
Outside Front Cover: Triplet–Triplet Annihilation Upconversion Circularly Polarized Luminescence That Originates From Achiral and Racemic Luminophores Encapsulated in Chiral Silica (Angew. Chem. Int. Ed. 29/2026)
Inside Front Cover: Covalently Hydrophobic Nanocarbon Supported Ni Single‐Atom Catalysts for Highly Selective CO <sub>2</sub> Electroreduction (Angew. Chem. Int. Ed. 29/2026)
A Pioneer of Directed Evolution in Catalysis: Manfred T. Reetz (1943‐2026)
Covalently Hydrophobic Nanocarbon Supported Ni Single‐Atom Catalysts for Highly Selective CO <sub>2</sub> Electroreduction
ABSTRACT Precise tailoring of hydrophobic microenvironments surrounding catalytic active sites has emerged as a critical strategy for enhancing the efficiency of...
Triplet–Triplet Annihilation Upconversion Circularly Polarized Luminescence That Originates From Achiral and Racemic Luminophores Encapsulated in Chiral Silica
ABSTRACT Circularly polarized luminescence (CPL) has emerged as a key optical property with chiral‐photonic and optoelectronic applications. However, conventiona...
Promiscuity‐Guided Enzyme Evolution via Substrate Multiplexed Screening
ABSTRACT An enzyme's ability to react with diverse substrates while maintaining high yield and selectivity, termed “substrate promiscuity,” is a highly sought‐after property in bioca...
A Hydroxy‐Substituted Trialkyloxonium Ion and Its Oxonium Alkoxide Zwitterion
ABSTRACT Trialkyl oxonium salts are among the most powerful electrophiles known. They are immediately quenched by nucleophiles like alcohols and halide ions, and...
An Agonist/Antagonist Photo‐Switchable Vitamin D Mimetic Enables Bidirectional Optical Control of VDR
ABSTRACT The secosteroid vitamin D (vitD) is essential for human health, maintaining bone metabolism, calcium homeostasis, and immune function via the vitamin D receptor (VDR). VDR a...
Selective Nitrate Transmembrane Transport Through Adaptive Weak C─H Bonding Cyanostilbene Water Channels
ABSTRACT Transmembrane water transport strongly depends on how dynamic, translocating water clusters are stabilized within hydrogen‐bonding (HB) channels. Both s...
Ampere‐Level Syngas Synthesis by Controllable Active Hydrogen Supply to Regulate CO <sub>2</sub> Reduction Depth on High‐Entropy (CuZnAlZrCe)O <sub>2</sub> Oxide Nanosheets
ABSTRACT Syngas synthesis via CO 2 electroreduction offers a low‐temperature carbon‐neutral route, yet with poor H...
Spin‐Dominated Reconstruction Kinetics in Prussian Blue Analog Enables Efficient Seawater Splitting
ABSTRACT The spin state of metal centers is identified as a pivotal descriptor dominating the electrochemical reconstruction kinetics of Prussian blue analogs (P...
In Situ Eu Redox in Cs <sub>3</sub> YCl <sub>6</sub> Enabling Colorful Scintillators for Multicolor Radiography and Real‐Time Dosimetry
ABSTRACT Colorful scintillators with multilayer structures have attracted considerable attention for advanced radiography, but their layered architectures suffer...
Leveraging Conformational Dynamics of MOFs to Overcome Conversion‐Selectivity Trade‐Off in CO <sub>2</sub> Hydrogenation to Ethanol
ABSTRACT In this study, we exploit the structural dynamics of MIL‐53(Al) metal‐organic framework (MOF) to develop a highly efficient and selective aqueous‐phase...
Embedding Chemistry and Pharmacy Into Sustainability
ABSTRACT Chemistry and pharmacy provide products and processes that are essential to our high standard of living. Chemistry is the central science when it comes to the transformation...
Photocatalytic Solar Hydrogen Peroxide Production on Donor+Acceptor Linear Polymer Semiconductor Powders Reconfigurable by H‐Bonding and π‐Stacking Interactions
ABSTRACT Developing an artificial photosynthesis technology that converts earth‐abundant resources into fuels using metal‐free photocatalysts with water as an el...
Site‐Specific Ir Single Atoms in Spinel Induce 5 <i>d</i> Spin Polarization for Enhanced Oxygen Evolution
ABSTRACT Precise control of the coordination environment of single‐atom centers is essential to reveal how local symmetry governs electronic structure and cataly...