Angewandte Chemie International Edition
Articles in this Issue
Visual β‐Sheet‐to‐β‐Turn Transition in Luminescent Polymeric Vesicles for Color‐Reporting Drug Delivery
Abstract The secondary structures of polymers significantly influence their properties; however, understanding and modulating polymer conformations remain substantial challenges. Par...
Unraveling the Mode of Action of a Neuron‐Specific Fluorescent Probe, NeuO: Intracellular Phosphorylation Through PAK6 Kinase
Abstract NeuO is an intriguing molecular probe capable of selectively labeling live neurons within a heterogeneous population of brain cells. The precise mechanism responsible for th...
Harnessing Pyridinic N Vacancy Defect in Microporous Structures to Induce the Pre‐Adsorption of Oxygen and Boost Oxygen Reduction Reaction Kinetics
Abstract Defect structures within the carbon matrix play a crucial role in enhancing the oxygen reduction reaction (ORR) activity of Fe single atom and nitrogen‐...
Catalytic Enantioselective Diboration of 1,2‐Dihydropyridines
Abstract Dihydropyridines undergo enantioselective 1,4‐diboration in the presence of a chiral Pt‐based catalyst. The resulting diboryl piperidines can undergo di...
Logic‐Gated Release of a Dual Payload from a β‐Lactam Mechanophore with a Rotaxane Actuator
Abstract The force‐controlled release of functional molecules has attracted interest due to its potential use in drug delivery and self‐healing applications. Clever mechanochemical d...
Enantioselective Synthesis of ε‐Lactams via Rh(I)‐Catalyzed C─C Bond Activation
Abstract ε‐Lactams are important structural motifs in medicinal chemistry, but a fully enantioselective synthesis without byproduct formation represents a challenge that has attracte...
“Strong Assisting Weak” Effect for Long‐Lived Room Temperature Phosphorescence in Host–Guest‐Doped Systems
Abstract Organic room temperature phosphorescence (RTP) materials, with long lifetime, large Stokes shift, and high signal‐to‐noise ratio, have great potential in numerous fields. An...
Radical C─H‐Aroylation of Allenes via Cooperative Photoredox and <i>N</i> ‐Heterocyclic Carbene Catalysis
Abstract This study demonstrates the use of cooperative photoredox and N ‐heterocyclic carbene (NHC) catalysis for sp...
Ethynylsulfone‐Based Phenol‐Yne Click Polymerization Toward Multiple Stimulus‐Responsive Poly( <i>β</i> ‐aryloxylvinylsulfone)s
Abstract We reported a metal‐free ethynylsulfone‐based phenol‐yne click polymerization for the efficient synthesis of stereoregulated poly( β...
A Molecular Staircase Built from Hydrazide‐Linked Pyridines as an Artificial Proton Channel
Abstract Artificial proton channels exhibiting high selectivity remain largely unexplored, with only two such systems recently reported. Inspired by the DNA dupl...
Transition Metal‐Free Formal C─H/C─H Coupling of Arylacetamides and Sulfoxides: An Interrupted Pummerer/[2,3]‐sigmatropic Rearrangement Sequence
Abstract Arylacetamides are important structural motifs found in many bioactive compound classes. Given their significance, the selective decoration of arylaceta...
Structural Insights Into Phase Formation of Sodium Layered Cathodes Materials with Prominent Electrochemical Performances
Abstract The electrochemical performances of layered cathodes for sodium‐ion batteries (SIBs) are intimately dependent on their structural characteristics. Howev...
Ketenimine Multicomponent Strategy for Multifaceted Amidine Functionalization of Peptides on the Solid Phase
Abstract The amidine group and its derivatives serve as proteolytically stable bioisosteres of the peptide bond, and their selective incorporation into peptides attributes significan...
Nondestructive Patterning of Upconverting and Down‐Shifting Luminescent Nanoparticles for Information Encryption
Abstract Patterning luminescent colloidal nanoparticles (NPs) at the micro‐ and nanometer scale is crucial for their integration into advanced solid‐state optica...
Engineering Peripheral Metal‐Oxide Catalysis: Interparticle Spacing in Cu/ZrO <sub>2</sub> Catalysts for Methanol Synthesis by CO <sub>2</sub> Hydrogenation
Abstract The periphery surrounding oxide‐supported metal nanoparticles plays a crucial role in many catalytic reactions that exhibit strong metal‐oxide promotion...
Ionic Liquid‐Confined Covalent‐Organic Framework Pores as Nanoreactors for CO <sub>2</sub> Photoconversion
Abstract The topological nanopores of covalent organic frameworks (COFs) show promise as spatially confined nanoreactors for solar CO 2...
A Bambusuril Receptor Binds Charge Diffuse Anions in Water at Picomolar Concentrations
Abstract Anionic pollutants are widespread in the environment and pose risks to human health. Due to the typically low concentrations of these species, the development of efficient r...
Outside Front Cover: Logic‐Gated Release of a Dual Payload from a β‐Lactam Mechanophore with a Rotaxane Actuator (Angew. Chem. Int. Ed. 37/2025)
Simultaneous Modulation of Mesoporosity and Al Siting for Superior Performance Zeolite Catalyst in Ethylene Dehydroaromatization to Aromatics
Abstract Porosity and Al siting are key levers for optimizing zeolite catalysts, yet they are often addressed independently due to the lack of effective integrat...
Synthesis and Structure of Neopentyl Sodium: A Hydrocarbon‐Soluble Reagent for Controlled Sodiation of Non‐Activated Substrates
Abstract While recent studies have shown that organosodium reagents can offer excellent promise in organic synthesis, their widespread applications can be hinder...
Molecular‐Level Design of Polymeric Semiconductor Nanomotors with Multichannel Sensitive 3D Motion for Microorganism Inactivation
Abstract The advancement of high‐performance photocatalysts is crucial for the iteration of light‐driven micro/nanomotors. However, most existing light‐driven mi...
Ni‐Bis(dithiolene) Coordination Enhanced Dual‐Functional Covalent Organic Frameworks for both Cathodic Zn <sup>2+</sup> Storage and Anodic Zinc Deposition Control in Aqueous Zn‐Ion Batteries
Abstract In response to the increasing demand for sustainable energy storage solutions, aqueous zinc‐ion batteries (AZIBs) have garnered significant attention fo...
Enhancing CO <sub>2</sub> Photoreduction Efficiency Through Improved Interaction Enabled by a Decorated Covalent‐Organic Framework
Abstract Photoreduction of CO 2 is often hindered by the sluggish kinetics for its activation. Refinement of host–guest i...
Individual Virus Detection by Peptide–Gold Nanocluster‐Assembled Artificial Binder
Abstract Ultrasensitive point‐of‐care detection is urgently required for viruses with high infectivity and lethality rates. In this study, we developed a direct detection platform, a...
Mitochondria‐Targeted Molecular Tools in Precise Tumor Therapy
Abstract Precise therapy for tumors faces challenges associated with traditional methods, such as low targeting efficiency, substantial side effects, and drug resistance. As the core...