Angewandte Chemie International Edition
Articles in this Issue
Axial Coordination and Defect Engineering of Copper‐Based Single‐Atom Nanozymes: Driving Synergistic Disulfidptosis and Pyroptosis for Efficient Prostate Cancer Immunotherapy
ABSTRACT Immunotherapy for prostate cancer is severely restricted by the immunosuppressive tumor microenvironment (TME) and the intrinsic antioxidant defense sys...
COF@DNAzyme Empowering Endogenous Copper for One‐Stitch Bioorthogonal Catalysis‐Based Anticancer Therapy
ABSTRACT Bioorthogonal chemistry, particularly the copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) reaction, holds great promise for in situ prodrug activation to minimize system...
High‐Entropy Phosphide‐Polymer Nanointerfaces Enable Adaptive Li <sup>+</sup> Transport for High‐Performance Solid‐State Li Metal Batteries
ABSTRACT Solid polymer electrolytes (SPEs) hold broad prospects in solid‐state lithium metal batteries due to their facile processability, favorable interfacial...
Hyperpolarization of Pyridine <sup>15</sup> <i>N</i> ‐Oxide Molecular Probes Enabled by Parahydrogen
ABSTRACT Magnetic resonance (MR) is a powerful non‐invasive technique for probing structural, functional, and metabolic processes with high spatial and temporal...
Enriched and Sustained Oxygen Vacancies in Amorphous NiWO <sub>x</sub> Enhance and Stabilize Urea Electrooxidation
ABSTRACT Urea electrolysis is promising for energy‐saving hydrogen production and effective treatment of urea‐polluted water. However, the activity and stability...
“Molecular Shakers” as Transmembrane Single‐Molecule Channels Toward 1:1 Cl <sup>−</sup> /K <sup>+</sup> Cotransport
ABSTRACT Cation–chloride cotransporters (CCCs) are an important family of chloride channel proteins that mediate electroneutral transport of Cl...
Metal–Organic Flexible Glasses Deliver Time‐Chirality‐Color Multi‐Dimensional Photonic Switches
ABSTRACT Combining color tunability with high processability in active optical waveguides remains a major challenge, as conventional crystalline materials are fundamentally limited b...
Modular Assembly of Bioconjugates Enabled by a Pyridine‐Based Chemoselective Sequential Conjugation Platform
ABSTRACT Site‐selective Cys bioconjugation is central to chemical biology and therapeutic development. Owing to the widespread availability of amine‐containing building blocks, the m...
Magnetic‐Field‐Enabled Ultrafast Quench Synthesis of Single‐Atom Catalysts for Efficient Anion Exchange Membrane Water Electrolysis
ABSTRACT Single‐atom catalysts (SACs) play a critical role in diverse catalytic applications, but their efficient synthesis remains a significant challenge. Here...
Harnessing Immunogenic PANoptosis With Iridium(III) Biradical Photosensitizers for Melanoma Photoimmunotherapy
ABSTRACT The efficacy of photodynamic therapy (PDT) is fundamentally constrained by an intrinsic photophysical trade‐off between its two ROS‐generating mechanisms. Type I pathways re...
Selective Degradation of Polyurethanes in Mixed Plastic Wastes via Ir‐Catalyzed Hydrogenolysis
ABSTRACT Chemical recycling of plastic waste has been widely undertaken to address a circular carbon economy. However, the presence of different polymers or comp...
Engineering LE–CT State Synergy in Aminoboranes for Single Molecule White Light Emission and Dual‐Mode Chiroptical/Phosphorescence Output
ABSTRACT Axially chiral aminoboranes that integrate multiple emissive functions within a single molecular framework are reported. These compounds exhibit dual emission, originating f...
Covalent Organic Framework Photocatalysts: Decoding Linkage Chemistry in Hydrogen Peroxide Synthesis From Air and Water
ABSTRACT Covalent organic frameworks (COFs) provide a polymer platform for exploring covalent linkages to design ordered skeletal and porous architectures. Howev...
Anisotropic Magneto‐Chiral Dichroism in Lanthanide Complexes
ABSTRACT In this work, we report the preparation of a chiral Er(III) complex specifically designed to assess the influence of the magnetic anisotropy axes orientation on its magneto‐...
Editable Hydrogen Bond Network Within the Electric Double Layer for CO <sub>2</sub> Reduction
ABSTRACT The hydrogen bond network (HBN) of water is dynamic and highly sensitive to electrified interfaces, where its rigidity can be significantly altered. Tun...
Strain‐Tuned d‐Band Center Coupling Dual‐Plasmon Effect in CuIn Alloy for Driving CO <sub>2</sub> Photoreduction
ABSTRACT Photocatalysis driven by plasmon effect offers a green and sustainable method for converting CO 2 into liquid fu...
Anomeric Amide Enabled Divergent Synthesis of Unsymmetrical Ureas, Carbamates, Thioesters, and Amides From Aldehydes
ABSTRACT Divergent synthetic transformations that convert a single precursor into a range of structurally distinct products are powerful tools for rapidly explor...
Efficient and Safe Membrane‐Free Flow Electrolyzer for Formate Synthesis and Direct Fuel Cell Integration
ABSTRACT Membrane‐free electrocatalysis represents a promising alternative to conventional systems, yet the potential H 2...
Modular Core‐Substituted Naphthalenediimide‐Based Metal–Organic Frameworks for Red‐Light‐Driven Photocatalysis
ABSTRACT Red‐light‐driven photocatalytic reactions present a superior alternative for overcoming inherent limitations of conventional ultraviolet (UV) and blue‐l...
Direct Growth of Na‐Ion Conducting Na <sub>3</sub> O <sub>15</sub> Si <sub>6</sub> Y Solid Glass Electrolyte With Reduced Interfacial Resistance for Safer Room‐Temperature Sodium–Sulfur Pouch Cells
ABSTRACT The stability of the solid electrolyte–electrode interface is critical for solid‐state batteries. Traditionally developed solid electrolytes are prone t...
Synergizing Schottky/S‐Scheme Dual‐Junction With Cu/Pb Dual‐Site in a 0D/3D Cu@CsPbBr <sub>3</sub> /g‐C <sub>3</sub> N <sub>4</sub> Heterojunction for Efficient CO <sub>2</sub> ‐to‐C <sub>2</sub> H <sub>4</sub> Photoreduction
ABSTRACT The CO 2 photoreduction to multi‐carbon products, particularly C 2 H...
Beyond the Fixed Charge: A New On‐Tissue Derivatisation Strategy Employing Photoionisable Chromophores for Mass Spectrometry Imaging of Amino‐Containing Metabolites
ABSTRACT Matrix‐assisted laser desorption/ionisation mass spectrometry imaging (MALDI‐MSI) has been widely adopted for the spatially resolved mapping of chemical...
Closed‐loop Recyclable and Robust Supramolecular Hydrogel Electrolytes With High Zinc Ion Mobility for Stable Zinc Anode
ABSTRACT Hydrogel electrolytes are promising candidates for zinc‐based energy storage systems (ZESs) owing to their superior safety features, favorable ionic con...
Strain‐Release Pentafluorosulfanylation of Carbonyl‐Containing Disubstituted Bicyclobutanes: A Fortuitous Path to SF <sub>5</sub> ‐Containing Oxa[2.1.1]bicyclohexanes
ABSTRACT The recent merger of pentafluorosulfanylation with strain‐release functionalization logic—largely enabled by an increase in SF 5...
<i>N</i> ‐Alkoxysulfurdiimide Reagents for the One‐Step Modular Synthesis of Primary Sulfonimidamides
ABSTRACT Sulfonimidamides are an emerging motif in medicinal chemistry; however, current synthetic routes often require multistep reaction sequences, deprotectio...