Angewandte Chemie International Edition

Reaction Environment Engineering for Selective C ₃₊ Formation in CO ₂ Electroreduction: Progress and Perspectives

ABSTRACT Electrocatalytic CO 2 reduction (ECRR) offers a sustainable way to produce high‐value chemicals. While C...

Excellent Overall Water Splitting Catalyst of Single Phase 6H Triple Perovskite Ba ₃ Co(Co _0.25 Ru _0.75 ) ₂ O ₉ at 1 A cm ⁻² for 1000 h

ABSTRACT Developing efficient bifunctional electrocatalysts for overall water splitting (OWS) remains a critical challenge due to the divergent reaction mechanis...

Simultaneous Construction of Sulfur and Carbon Stereocenters via Asymmetric Desymmetrization of Sulfonimidamides With Oxindole Derivatives

ABSTRACT Sulfonimidamides are highly appealing owing to their capacity for extensive structural diversification and their broad‐spectrum, versatile bioactivities...

Oxidative Porphyrinoid Metamorphosis of Fourfold N‐Confused [32]Octaphyrin Bis‐Metal Complex to Doubly Linked 10‐Oxacorrole Metal Complex Dimer

ABSTRACT We report an oxidative skeletal editing strategy that converts antiaromatic expanded porphyrins into structurally and electronically distinct porphyrino...

Multi‐Level Asymmetric Mesoporous Nanochannels for Photothermal‐Regulated Dopamine Sensing

ABSTRACT Bioinspired nanochannel systems provide attractive platforms for coupling molecular recognition with ion transport regulation; however, integrating sele...

“Alkaline‐Hammer Strategy” Breaks Acidic and Stromal Barriers to Induce Alkaliptosis and Enhance Immunotherapy in Pancreatic Cancer

ABSTRACT Immunotherapy for pancreatic cancer remains a formidable challenge due to the highly immunosuppressive tumor microenvironment (TME), characterized by de...

Virus‐Mediated Self‐Assembly of Functional Cyclodextrins for Antiviral Inhibition

ABSTRACT We report a virus‐mediated supramolecular assembly as an adaptive inhibitor of viral infection. Building on cyclodextrin (CD) host–guest self‐assembly, we designed a monomer...

An Engineered Enzyme Catalyzing Tandem Reductive Aminations for Synthesizing Tertiary Amines

ABSTRACT Tertiary amines are privileged motifs in bioactive molecules. However, their chemical synthesis lacks sustainability, and biocatalytic alternatives rema...

Click'n ROPISA: One‐Pot Synthesis of Ultrabright Fluorescent Nanoparticles Made of Polypeptides

ABSTRACT Fluorescent nanoparticles are widely used in bioimaging and sensing, yet their preparation relies on multistep synthetic routes that limit scalability a...

Outside Front Cover: The Missing Link in Ferrocenophane Chemistry: Isolation of a Carba[1]Ferrocenophane

Solar‐Driven Reversible Hydrogen Storage Over LiNH ₂ ‐2LiH

ABSTRACT Lithium amide‐lithium hydride composite (LiNH 2 ‐2LiH), a composite hydride with a high hydrogen capacity of 10....

Outside Front Cover: Nucleophilic Gallyl Anions Enable Ga–Au Bimetallic Ammonia Activation

Triple‐Microenvironment Decoding Enables Logic‐Unlocked Precision Photoimmunotherapy

ABSTRACT Achieving tumor‐specific activation of pyroptosis and ferroptosis holds great promise for cancer immunotherapy, yet current photosensitizers (PSs) capab...

Unlocking Zn‐Ion Diffusion in Disordered Rocksalt Cathodes for Nonaqueous Zn‐Ion Batteries

ABSTRACT Multivalent batteries, particularly zinc‐ion batteries (ZIBs), are promising candidates for high‐energy–density energy storage. However, their developme...

Water‐Dispersible Ruthenium Nanocatalyst for Carbonyl Reduction With D ₂ or T ₂ in Aqueous Media

ABSTRACT The growing development of biologics as therapeutic agents urges the development of efficient catalytic methods enabling the direct incorporation of hydrogen isotopes from r...

Rational Tailoring of Hole‐Selective Self‐Assembly Monolayers Based on Sulfur‐Containing Heterocycles for High‐Performance Perovskite Solar Cells

ABSTRACT Conventional hole‑selective self‑assembled monolayers (SAMs) for perovskite solar cells (PSCs) have largely focused on tuning electronic properties whil...

Asymmetric Total Synthesis of (+)‐Ineleganolide

ABSTRACT Polycyclic cembrane diterpenoids and norditerpenoids have garnered sustained interest from the synthetic community due to their unique polycyclic frameworks and promising bi...

Chemoenzymatic Synthesis of Heparan Sulfate Oligosaccharides by a Covalent Catch‐and‐Release Approach

ABSTRACT A covalent catch‐and‐release approach is described for the chemoenzymatic synthesis of HS oligosaccharides. It exploits that a glycan modified by a hydrazide tag can under m...

An Oligomeric Additive Bridges Inner and Outer Helmholtz Planes to Enable Reversible Zn Anodes via Spatial and Functional Decoupling

ABSTRACT Precise molecular engineering of the electrode/electrolyte interface remains a key bottleneck for aqueous Zn‐ion batteries (ZIBs). Here, we report an ox...

Peptide Thioester and Triazole Derivatives Through On‐Resin Dual‐Modification of Peptide Thiosulfonates

ABSTRACT Modified peptides are an important class of drugs due to their high specificity and affinity in particular to pharmacological targets that are not druggable by conventional...

Iridium‐Catalyzed Ionic Hydrogenation of Multi‐Aza Heterocycles

ABSTRACT Nitrogen‐containing‐heterocycles are a cornerstone of biologically active molecules, natural products, and pharmaceuticals. Saturated heterocycles can l...

Ligand‐Mediated Reprogramming Redirects Liver‐Tropic Ionizable Lipid Nanoparticles for Lung‐Selective mRNA Delivery

ABSTRACT Systemic delivery of messenger RNA (mRNA) to target tissues and cells using lipid nanoparticles (LNPs) holds transformative potential for gene therapy. However, most clinica...

Eteri Svanidze

Rapidly Diversifying Hydrogen‐Bonded Organic Frameworks With Permanent Porosity

ABSTRACT Throughout the long history of porous molecular crystals (PMCs), hydrogen‐bonded organic frameworks (HOFs) have experienced a renaissance and have advanced significantly ove...

A New Switchable Zr ₁₂ Oxocluster Based Large Pore Metal–Organic Framework Functionalized With Spin Crossover Complexes for Acetic Acid Colorimetric Sensing

ABSTRACT Acetic acid sensing is a critical and challenging subject in the industrial, chemical, cultural heritage, and health sectors. While metal–organic Framew...