Angewandte Chemie International Edition

Chiral (R/S‐MPz)Ge ₄ I ₁₀ With Unique 2D [Ge ₄ I ₁₀ ] Layered Structure and Large Chirality‐Induced Nonlinear Optical Effect

ABSTRACT Chiral organic–inorganic hybrid metal halides (OIMHs) with intrinsic non‐centrosymmetric structures have attracted considerable attention for their pote...

Stereodefined Improbable [3]Rotaxane by Post‐Interlocking Ring Editing

ABSTRACT The synthesis of higher‐order mechanically interlocked molecules is challenging when targeting so‐called improbable rotaxanes—statistically disfavored a...

Ring‐Opening Arylation of Cyclic Diaryliodoniums via Cyclic Triaryliodanes as Aryne Precursors and Dynamic Aryl Reservoirs

ABSTRACT Cyclic diaryliodonium salts are widely employed as linchpins for constructing functionalized biaryls and as precursors to arynes under basic conditions....

Correction to “Charge‐Driven Self‐Assembly of Cholesterol Surfactants into Biofunctional Nanodiscs with Antiviral Activity”

Hsuan‐Hung Liao

Circumstellar Origin of Chrysene (C ₁₈ H ₁₂ ) via Self‐Recombination of Resonantly‐Stabilized 1‐Indenyl Radicals and Implications to the Aromaticity of the Carbonaceous Asteroid Ryugu

ABSTRACT Polycyclic aromatic hydrocarbons (PAHs) represent key molecular building blocks of carbonaceous nanoparticles and have been identified in cold molecular...

Imaging of <i>Staphylococcus aureus</i> Infections and Biofilms Using a Selective Covalent Probe for the Unique Serine Hydrolase FphE

ABSTRACT Staphylococcus aureus is the leading cause of soft tissue infections which can often be treated with antibiotics. However, it can al...

Dual Single‐Atom Catalysts Unveiling Active Sites for Enhanced Ethylene Methoxycarbonylation

ABSTRACT Designing heterogeneous catalysts with well‐defined structure remains crucial for identifying true active sites and achieving superior performance. Here...

Boosting Triplet Exciton Harvesting via Multi‐Channel High‐Lying Reverse Intersystem Crossing in a Hot Exciton Material Featuring Locally Excited‐State Emission

ABSTRACT Hot exciton (HE) materials possessing a locally excited (LE) S 1...

Mechanically Robust Ultrahigh Molecular Weight Supramolecular Hydrogels Reinforced by Synergistic Chain Entanglement, Hydrogen Bonding, and Nanoparticle Incorporation

ABSTRACT Tuning the mechanical properties of ultrahigh molecular weight (UHMW) physically crosslinked hydrogels remains a significant challenge. We address this...

A Nanoconfinement Strategy for Regulating Cluster Size to Enable Color Tuning in Clustering‐Triggered Phosphorescence

ABSTRACT In clustering‐triggered emission systems, molecules generally form clusters of various sizes, making it difficult to rationally design materials that emit a desired phosphor...

Decoupling Hydrogen Evolution From Continuous Irradiation via CO ₂ ‐Mediated Proton‐Coupled Electron Storage

ABSTRACT The intermittent nature of solar energy and the safety concerns of high‐pressure hydrogen storage/transportation pose critical challenges to the widespr...

Inside Front Cover: Proximity‐Induced Transfer of a Mass Tag Enables Direct Profiling of Active Matrix Metalloproteases (Angew. Chem. Int. Ed. 24/2026)

Transforming Interfacial Reactivity Into Stability for Durable High‐Current Solid‐State Sodium Batteries

ABSTRACT Interfacial instability remains the key obstacle to reliable oxide‐based solid‐state batteries (SSBs). Here we demonstrate a monolithic, self‐regulating...

From [NHC─H] ^• to Persistent <i>σ</i> ‐Complex Radicals: Photoinduced Radical Chemistry of Imidazolium Salts

ABSTRACT Imidazolium salts are ubiquitous precursors to N ‐heterocyclic carbenes (NHCs), yet their radical chemistry rema...

Programmable Morphing DNA Nanodevice Enables Triple Signal Amplification for Long‐Term Early Tumor Metastasis Imaging

ABSTRACT Accurate early detection of tumor metastasis remains a formidable clinical challenge owing to the lack of imaging tools that can simultaneously respond sensitively to early...

A Negatively Curved Pyrene‐Fused Azaacene

ABSTRACT Non‐planar aromatic hydrocarbons display distorted π‐frameworks that give rise to unique optoelectronic properties. Among the different strategies for generating non‐planar...

Selective <i>Para</i> ‐Functionalization of Aromatic C(sp ² )─H Bonds via Atomically Dispersed Photocatalysis

ABSTRACT Direct functionalization of aromatic C─H bonds is crucial in organic synthesis due to their wide applications in pharmaceutical chemistry and materials...

Programmable Chimeric Antigen Receptor T Cell Circuits With DNA Computing for Precision Tumor Therapy

ABSTRACT Chimeric antigen receptor (CAR) T cells, a promising cancer therapeutics, still face challenges in safety and efficacy due to the incapability to precisely regulate T cell a...

Discovery of Perilloxazole Pseudo‐Natural Products Yields a New Sterol Biosynthesis Inhibitor Chemotype

ABSTRACT Pseudo‐natural products (PNPs) are new arrangements of natural product (NP) fragments, creating chemical spaces that extend beyond those explored by nature and are unattaina...

Topological Engineering From Non‐Emissive Chiral Metallomacrocycle to Interlocked Architecture for Strong Circularly Polarized Luminescence

ABSTRACT Interlocked architectures are crucial for stabilizing specific conformations to achieve superior performance. Herein, we proposes a vacant π‐site recomb...

Multiple‐Bonding and Lability: Study of an Anionic Vanadium Alumanyl

ABSTRACT An anionic vanadium alumanyl complex is prepared by a reaction of neutral vanadocene and an alumanyl anion. Single‐crystal XRD revealed a significantly...

Bioinspired Molecular Engineering of IRE1‐Gated DNAzymes for Self‐Adaptive Bidirectional Modulation of ER Stress

ABSTRACT Precise regulation of endoplasmic reticulum (ER) stress signaling in cancer remains a central challenge for nucleic acid–based therapeutics, largely due...

Hydrogen Isotope Exchange in Pyridine Catalyzed by an Iron(II) Imido Complex: Counterion‐Directed Regioselectivity

ABSTRACT High‐spin ( S = 2) iron(II) imido complexes [Ph 2 B(...

Reactant‑Transporting Metal‐Support Interaction for Lattice Carbonate‑to‑Methane Catalysis

ABSTRACT As a core concept of heterogeneous catalysis, metal‐support interactions are pivotal controlling activity, selectivity, and stability via electronic and...