Angewandte Chemie International Edition
Articles in this Issue
Selective and Potent First‐in‐Class CRBN‐Dependent Molecular Glue Degraders of WW Domain‐Binding Protein 4
ABSTRACT Targeted protein degradation via molecular glues represents a powerful modality for modulating “undruggable” proteins. Herein, through proteomic profiling of a CRBN‐binding...
Regulating Electrolyte Microstructure via Anion‐Solvent Coordination Enables Fast Interfacial Kinetics Toward Practical Zinc Pouch Cells
ABSTRACT Solvation structure regulation plays crucial roles in stabilizing the Zn anode by suppressing dendrite and hydrogen evolution, but sluggish ion transpor...
Redox State‐Dependent Dinitrogen Binding by an Isocyanide Analogue of 15e <sup>–</sup> CpCr(CO) <sub>2</sub>
ABSTRACT The low‐valent 15e − monovalent chromium complex, Cp*Cr(CNAr Dipp2 )...
Isolable <i>C</i> ‐Phosphonio‐Boratavinyl Anion
ABSTRACT A persistent C ‐phosphonio boratavinyl anion 1 has been successfully syn...
Manganese‐Catalyzed Asymmetric Transfer Hydrogenation of Polarized Olefins via a Collaborative Hydrogen Transfer Process
ABSTRACT Asymmetric (transfer) hydrogenation of olefins is an important route to chiral molecules used in pharmaceuticals, agrochemicals, and fine chemicals. Alt...
Quantification of Molecule‐Defect Site Binding Force Via Single‑Molecule Adhesion
ABSTRACT The binding strength between reactant molecules and active sites fundamentally governs reaction selectivity and efficiency, as it determines adsorption...
Periplasmic FeS Electron Conduits: Tuning Electrocoupling and Respiratory Dehalogenation in a Synthetic Consortium
ABSTRACT Electron delivery within and between bacterial cells is a central bottleneck in anaerobic biotransformation of electron acceptor‐type substrates (EATS)....
Chlorine‐Free Depolymerization of Commercial PMMA via Oxygen‐Centered Radicals
ABSTRACT Mid‐chain depolymerization enables chemical recycling of conventional plastics with carbon–carbon backbones into high‐purity monomers under mild conditions and without any w...
F‐Center‐Mediated Valence Engineering of Europium in Fluoride Nanoscintillators Toward Diverse Optical Sensing
ABSTRACT Lanthanide‐doped fluoride nanoscintillators (NSs) are promising candidates for x‐ray imaging, owing to their high environmental stability, controllable...
One Molecular Platform, Three Distinct Narrowband Organoboron TADF Emitters: A Divergent One‐Pot Strategy From Green to Red
ABSTRACT Multi‐resonance thermally activated delayed fluorescence (MR‐TADF) emitters enable narrowband electroluminescence with exceptional color purity in organ...
Ancillary Ligand‐Controlled Dinitrogen Cleavage and Transformation at Titanium Centers
ABSTRACT The activation and transformation of dinitrogen (N 2 ) represents a significant scientific challenge. In particu...
Engineering Frustrated Packing of Porous Organic Cages for Precision Acetylene–Ethylene Separation
ABSTRACT Porous organic cages (POCs) are emerging porous molecular materials with their tunable porosity and solution processability. Beyond the intrinsic pores...
An Enzymatic Platform for Late‐Stage (Radio)isotope Labelling of Oligonucleotides With Methyltransferases
ABSTRACT The development of therapeutic nucleic acids has become a cornerstone of modern drug discovery. To support the clinical translation of these modalities,...
Polymorphism in Covalent Organic Frameworks Regulates Excited Dynamics for H <sub>2</sub> O <sub>2</sub> Photosynthesis Coupled With Biomass Valorization
ABSTRACT Polymorphism in covalent organic frameworks (COFs) offers a unique platform to decipher structure–property relationships, yet its impact on excited‐stat...
Cobalt‐Catalyzed Reductive Asymmetric Dimerization of 1,3‐Enynes: Rapid Synthesis of Enantioenriched Skipped 1,3,6‐Trienes
ABSTRACT Enantioenriched skipped polyenes represent an important building block in natural products and bioactive molecules. Thus, it is of great importance for developing efficient...
Electrostatic Modulation of Central Units Enables High‐Performance Fused‐Ring Trimeric Acceptors
ABSTRACT Fused‐ring trimeric acceptor benefits from both the high symmetry/planarity of small‐molecule acceptors and the large glass transition temperature of polymeric acceptors, ma...
Circular Photocaged mRNA for Light‐induced Late‐stage Activation of Translation
ABSTRACT mRNA is a new medical modality as vaccine and raises hopes to become a protein replacement agent. Despite notable advances in manufacturing, stabilization and modification,...
Functionalization‐Mediated Synthesis of Bridge‐Coordinated Fe Atoms on MoS <sub>2</sub> Nanosheets for PEM Water Electrolyzers
ABSTRACT Transition metal chalcogenides are among the most promising platinum group metal‐free (PGM‐free) catalysts for hydrogen production in a proton exchange...
Intrinsically Flame‐Retardant Liquid Crystal Elastomers With Flame‐Triggered Actuation Enabled by Main‐Chain P─C Bond Incorporation
ABSTRACT Liquid crystal elastomers (LCEs) are promising soft actuators, but their practical use is constrained by the incompatibility between fire safety and reversible actuation. Ex...
Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential
ABSTRACT The dynamic glycan layer that surrounds human and microbial cells plays an essential role in the immune system's capacity to maintain immune tolerance and equilibrium, fight...
Aromatic Interaction‐Driven Adaptive Transformation of Macrocyclic Unimolecular Chloride Channels Into Nanopores
ABSTRACT Biological ion channels and pores frequently exhibit dynamic, concentration‐dependent adaptive assembly, yet synthetic systems that faithfully replicate...
Single Ga‐Atom Stabilized Cu <sup>+</sup> –Cu <sup>0</sup> Interfacial Sites for Efficient Air Plasma‐Derived Ammonia Electrosynthesis
ABSTRACT Electrocatalytic NO x reduction to ammonia (NO x RR) offers a sustainabl...
Dynamic Binding of Alkali‐Metal Ions in a Metalloporphyrin Cage: Impact on Redox Catalysis
ABSTRACT The influence of local electrostatic environments on catalytic reactivity is well established in enzymatic systems, but their systematic implementation...
Macrocyclic Dual‐ and Tetra‐Borated Multi‐Resonance Thermally Activated Delayed Fluorescence Materials Based on Tetraazacyclophane
ABSTRACT In multiple‐resonance‐induced thermally activated delayed fluorescence (MR‐TADF) materials with a meta B‐π‐B con...
Predicting Catalyst Performance From Pt/CeO <sub>2</sub> Redispersion Kinetics
ABSTRACT Quantitative description of the structural dynamics of nanoparticles by kinetic data is challenging but would represent a significant knowledge leap, as...