Angewandte Chemie International Edition
Articles in this Issue
A Versatile Strategy for Light‐Driven Active Transport of Ions
Abstract Transport across compartments is essential for biology to drive its vital processes. Chemists have developed synthetic transport systems, focusing mainly on passive transpor...
Selective Ion Transport Regulation Enables High Current Density CO <sub>2</sub> ‐to‐C <sub>2+</sub> Conversion in Acid
Abstract Electrochemical carbon dioxide reduction reaction (CO 2 RR) under acidic condition offers great promise to achie...
Characterisation of the <i>N</i> ‐Methyltransferase <i>Sg</i> PsmC: Application in the Kinetic Resolution of Pyrroloindolines
Abstract Many natural products and pharmaceutical compounds bear the pyrroloindoline scaffold, highlighting the importance of the heterocyclic motif. Here, we ai...
Fluoride‐Transfer Asymmetric Allylic Alkylation Enables Regiodivergent, Stereoselective Cross‐Electrophile Coupling
Abstract Asymmetric allylic alkylation (AAA) is a widely used strategy for stereoselective formation of C─C bonds. Yet, conventional methods often exhibit poor a...
Empowering Chemistry Experts with Large Language Models for Literature Interpretation in Single‐Atom Catalysis Toward Advanced Oxidation
Abstract Large language models (LLMs) hold considerable promise for large‐scale data extraction from scientific literatures for catalyst design and practical optimization. Yet, turni...
Tailoring Cathode Interphase Chemistry for High‐Voltage Li‐ion Batteries
Abstract To unlock the potential of cyclability and energy density of Lithium‐ion batteries (LIBs), cathode interphase engineering is pivotal. However, a compreh...
Water Networks as Hydrophobic Recognition Motifs in Proteins
Abstract The hydrophobic effect is a central force in molecular recognition, typically attributed to the ordering of water molecules around apolar groups. Hydrop...
Utilizing Similarity Measures to Map Chemical Reactivity
Abstract The development of fully autonomous chemical synthesis platforms requires robust, real‐time assessment of reactivity that does not rely on prior mechanistic knowledge. Exist...
Atomistic Landscape of Pt Nanoparticles via Machine Learning: How Size Effect and Hydrogen Adsorption Govern Structural Ensembles and Catalytic Activity
Abstract Understanding the atomistic structure and fluxionality of Pt nanoparticles under reactive conditions is essential for rational design of effective catal...
Template‐Controlled Mechanochemical Dissociation of a Rotaxane
Abstract The mechanochemical dissociation of rotaxanes has been used in the design of materials with the ability to dissipate energy and of force‐controlled rele...
Bifunctional Aziridines from Photochemically Generated FSO <sub>2</sub> NH <sub>2</sub> for SuFEx Diversification of Alkenes
Abstract Sulfonyl fluorides have emerged as ubiquitous reactive motifs in fields ranging from medicinal chemistry to materials science, with applications as chem...
PSMA‐Triggered Phase Separation of Peptide‐Drug Conjugates Enables Zinc‐Dependent Tumor Inhibition
Abstract Peptide‐drug conjugates (PDC) have emerged as a promising modality for targeted tumor therapy, offering high specificity, and design flexibility. However, the therapeutic ef...