Catalytic Enantioselective Diboration of 1,2‐Dihydropyridines

Abstract

Abstract Dihydropyridines undergo enantioselective 1,4‐diboration in the presence of a chiral Pt‐based catalyst. The resulting diboryl piperidines can undergo diverse stereospecific cross‐couplings, allowing the construction of an array of different substituted chiral piperidines. Density functional theory (DFT) calculations provide insight into a plausible diboration pathway that involves a platinum‐centered reaction between coordinated B 2 L 2 reagent and the diene to furnish an intermediate π–allyl platinum complex.