Angewandte Chemie International Edition
Articles in this Issue
Molecular Rotor‐Based NIR‐II TICTgens for Mitochondria‐Targeted Pyroptosis Induction and Multi‐Model Monitoring of Cancer Immunotherapy
Abstract Pyroptosis has emerged as a promising mechanism for eliciting robust antitumor immunity; however, the current pyroptosis inducers lack tumor‐selectivity and feedback of ther...
Quantum Chemistry Calculation‐Assisted Large‐Scale Collision Cross Section Prediction Empowers Derivatization‐Enhanced Multidimensional Metabolomics
Abstract Derivatization‐enhanced multidimensional metabolomics combined with ion mobility mass spectrometry will greatly improve the accuracy and coverage of met...
Inside Front Cover: Metastable Macrocyclic Bis‐Meisenheimer Adduct (Angew. Chem. Int. Ed. 38/2025)
Spillover‐Mediated H* Redistribution Promotes Electrocatalytic Acetonitrile Hydrogenation in PEM Reactors
Abstract Electrocatalytic acetonitrile hydrogenation (EAH) provides a sustainable route for ethylamine synthesis, yet suffers from low productivity, competitive...
Hydrophobic Poly(divinylbenzene) Polymer‐Supported Ruthenium Catalysts for Efficient Hydrogenation of Pyridines in Water
Abstract Gas–liquid–solid triphase reactions are limited by poor gas solubility and mass transfer, especially in water. The low solubility of hydrogen in water s...
Unsaturated Phosphine Oxides for Modular Antibody Rebridging and Single Reagent Peptide‐Cyclization‐Bioconjugation
Abstract Achieving modular, selective and homogeneous protein modifications is of utmost importance for the design of next generation biopharmaceuticals, especia...
In Situ Tracking of Ni‐MOF Reconstruction into Active Ni(OH) <sub>2</sub> OER Catalysts
Abstract The oxygen evolution reaction (OER) remains a key bottleneck in electrochemical energy storage and conversion. In this work, we demonstrate the transmut...
AI‐Driven Discovery and Molecular Engineering Design for Enhancing Interface Stability of Black Phosphorus
Abstract Molecular engineering offers significant potential for developing advanced interfacial materials, yet the complexity of organic molecules poses challeng...
Electronic Cloud Topology‐Driven Electrostatic Decoupling: To Suppress High‐Voltage Parasitic Reactions of Phosphate Cathode in Sodium‐Ion Batteries
Abstract The polyanionic structure cathodes with synergistic Mn/V redox couples enables high‐voltage platform and delivers considerable theoretical energy densit...
Elucidating Ligand Exchange Dynamics of Hexacyanochromate‐Based Redox Mediators in Aqueous Iron‐Chromium Redox Flow Batteries
Abstract Aqueous redox flow batteries (AQRFBs) are revolutionizing energy storage by integrating sustainability with cutting‐edge innovation. Among them, Iron‐Ch...
Synergistic Light‐Ultrasound‐Driven Hydrogen Production by Hydrogen Iodide Decomposition Over Dual‐Molecular Ferroelectric Heterostructure
Abstract Emerging catalytic systems for hydrogen production via solar and mechanical energy conversion often face critical challenges, including band mismatch, i...
Tailoring Lattice Oxygen Redox and Robust Structure Stability in High‐Entropy Superlattice Layered Cathode for Superior Potassium‐Ion Storage
Abstract To address the inherent limitations of layered cathodes in terms of stability, kinetics, and energy density, a high‐entropy superlattice layered oxide (...
Rational Design of CDK12/13 and BRD4 Molecular Glue Degraders
Abstract Targeted protein degradation (TPD) is an emerging therapeutic approach for the selective elimination of disease‐related proteins. While molecular glue degraders exhibit drug...
Unbiased Stable Photoelectrochemical Glycerol Oxidation on Hematite Photoanodes
Abstract Photoelectrochemical glycerol oxidation reaction (PEC GOR) is considered as one of the promising strategies for obtaining high‐value products and transf...
Efficient Electronic‐Structure Methods Toward Catalyst Screening: Projection‐Based Embedding Theory for CO <sub>2</sub> Reduction Reaction Intermediates
Abstract Catalyst screening is a demanding task for computational chemistry since the profound diversity of surface structures under operando...
Sub‐Nano Ir‐Based Alloy Clusters by Hierarchical Confinement Effect for Water Splitting
Abstract The synthesis of sub‐nanoscale noble metal catalysts is pivotal for enhancing electrocatalytic performance, yet achieving precise control over particle...
From Triplet to Twist: The Photochemical <i>E</i> / <i>Z</i> ‐Isomerization Pathway of the Near‐Infrared Photoswitch <i>peri</i> ‐Anthracenethioindigo
Abstract In recent years, large progress has been made to shift the absorption of photoresponsive molecules into the long‐wavelength region of the electromagneti...
Full‐Dimensional Control of Covalent Organic Frameworks Through Repulsion‐Torsion Effect: Prominent 1D Above 2D and 3D Structures
Abstract Exploring the impact of different dimensions on the properties and functions of covalent organic frameworks (COFs) has always been a key goal, as this can provide feedback t...
Controlling the Mechanical Response of Polymers via Metal Induced Coordination Conformational Changes
Abstract The modulation of mechanical properties in polymers with metal binding ligands has largely been achieved via crosslinking between polymer chains induced...
Molecular Design of Asymmetric Difluorinated Ether Electrolytes for Stable Operation of High‐Voltage Lithium Metal Batteries
Abstract Fluorination of electrolyte solvents is key to improving the cycling stability of high‐voltage lithium metal batteries (LMBs), yet the critical role of...
Bicyclo[1.1.0]tetragermane‐2,4‐diide Diradicaloid
Abstract The synthesis, structure, and reactivity of the bicyclo[1.1.0]tetragermane‐2,4‐diide compound [(ADC)Ge 2...
Copper Single‐Atom Catalyst for Efficient C─S Coupling in Thioether Synthesis
Abstract Carbon‐heteroatom cross‐coupling reactions have become indispensable tools in synthetic chemistry. However, the formation of carbon–sulfur (C─S) bonds, which are essential f...
Crown Ether–Peptide Rotaxanes
Abstract We report on the metal‐free active template synthesis of crown ether–peptide rotaxanes. A 24‐crown‐8 ring is sufficiently small that the side chains of...
Engineering Mechanostable Anticalin Scaffolds to Enhance Particle Adhesion and Targeting of CTLA‐4 Under Shear Stress
Abstract Achieving high binding strength and efficient delivery of molecular cargo to cells expressing biomarker targets is a significant challenge in drug delivery. Here, we investi...
Facet Engineering and Fe─N─Co Bridged Heterojunction Enable Fe <sub>3</sub> O <sub>4</sub> @C@ZIF67 as High‐Performance Photocatalyst for Ammonia Synthesis
Abstract Ammonia synthesis is vital for global fertilizer production but traditionally relies on the energy‐intensive Haber–Bosch process, a major contributor to...