Angewandte Chemie International Edition
Articles in this Issue
Fluorothiazynes as SuFEx Ambiphiles: Interconversion to Amino‐sulfurdiimidoyl Fluorides
Abstract Sulfur(VI) functional groups are ubiquitous in medicinal chemistry, valued for their stability and ability to modulate molecular properties. While sulfonamides, sulfones, an...
Pseudotetraivprolides from <i>Pseudomonas entomophila</i> Provide Insights into the Biosynthesis of Detoxin/Rimosamide‐Like Anti‐Antibiotics
Abstract Novel variants of known natural product (NP) classes can provide valuable insights into their biosynthesis, mechanisms of action, and potential as drug...
Engineering Photo‐Controlled Dynamic Conjugation Switching in Azine‐Linked Covalent Organic Frameworks for Boosted Photocatalysis
Abstract Photocatalysis holds transformative potential for addressing energy and environmental challenges. Covalent organic frameworks (COFs), with predesignable...
Homoleptic Bismuth Alkynes: Isolable Reagents for Selective Alkynyl Radical Transfer
Abstract Alkynyl radicals represent highly attractive building blocks in synthetic chemistry but keep posing considerable challenges to researchers in the field....
Electrolyte‐Engineered Photoelectrochemical Ammonia Oxidation Enabling Sustainable Hydrogen Production via Catalyst Regeneration
Abstract Ammonia oxidation reaction (AOR) offers a promising carbon‐free hydrogen production pathway under ambient conditions, yet practical implementation faces...
Transitioning of the Chemical Industry Toward a Net‐Zero Carbon Dioxide Emission Path
Abstract Emissions from the chemical industry, both for energy and use of raw materials, account for approximately 6% of man‐made greenhouse gas emissions. In or...
Stereochemical Dissection of the Strobilurin PKS Reveals the Complex Biosynthetic Logic of Iterative <i>EZE</i> Triene Construction
Abstract Type I Iterative polyketide synthases (PKS) use a limited set of catalytic extension and β‐processing domains to create complex polyketides. A remarkabl...
Outside Front Cover: An Orthogonal Nucleic Acid/Peptide Amplification Circuit Enables Protease‐Triggered, Cancer Cell‐Selective PD‐L1 Imaging (Angew. Chem. Int. Ed. 4/2026)
A Para‐Selective Kolbe–Schmitt Reaction
Abstract The Kolbe–Schmitt reaction is the archetypal carboxylation reaction in organic synthesis yet generally suffers from the requirement of high temperatures...
Correction to “Macrocyclic Peptide Probes for Immunomodulatory Protein CD <sub>59</sub> : Potent Modulators of Bacterial Toxin Activity and Antibody‐Dependent Cytotoxicity”
Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues
Abstract The unique potential of marine polyhydroxylated macrolides in chemical biology and drug discovery has long been constrained by their structural complexi...
Pure Molecular Inorganic Rings: Mixed Group 14/15 Metallacycles
Abstract A systematic study on the reactivity of the homodipnictogen tetrahedrane complexes [{Cp‘Mo(CO) 2 }...
Mechanochemical Synthesis of <i>X</i> ‐Vinylbenziodoxol(on)es and One‐Pot Conversion to Complex Alkenes <sup>**</sup>
Abstract Densely functionalized alkenes are often utilized as excellent tools for further functionalization of molecules. Recent progress in their synthesis incl...
An Orthogonal Nucleic Acid/Peptide Amplification Circuit Enables Protease‐Triggered, Cancer Cell‐Selective PD‐L1 Imaging
Abstract Molecular imaging offers a powerful approach for in situ detection of programmed death‐ligand 1 (PD‐L1), however, achieving cancer cell‐selective imaging that discriminates...
Stimuli‐Responsive Photoacid Polyelectrolytes
Abstract Spiropyran‐based polymers are widely studied on account of their multifaceted stimuli‐responsive behaviors. However, their photoacid characteristics in aqueous environments...
Tackling the Reactivity of Propadiene: Palladium Metallaphotoredox Dual Catalyzed Multi‐Component Allylation and Dienylation of Styrenes
Abstract Catalytic transformations of feedstock chemicals into value‐added products are a long‐standing challenge. A side product of the steam‐cracking process –...
Translation‐Promoting Effects of RNA Template Overhangs in the Absence of Ribosomes
Abstract Translation requires a complex set of biomacromolecules. How it evolved is an unsolved problem. Ribosome‐free, single‐nucleotide translation via coupling of 3′‐aminoacylated...
Optimized In‐Solution and Gas‐Phase Chemistry Enables High‐Efficiency Interactome Mapping by DSBSO‐Based Cross‐Linking Mass Spectrometry
Abstract Cross‐linking mass spectrometry (XL–MS) allows characterizing protein structures and interactions in highly complex samples. The enrichable disuccinimid...
Design and Experimental Validation of a Photocatalyst Recommender Based on a Large Language Model
Abstract Utilizing an extensive library of literature on photocatalytic transformations, we disclose the development of a machine learning (ML) model for the rec...
Bench‐Stable Boryl Thianthrenium Dication Enables Aziridinyl Boronate Synthesis via Metal‐Free Late‐Stage Aziridination with Diverse Nitrogen Nucleophiles
Abstract Organoboron compounds are indispensable in modern organic synthesis and biomedical research. This study describes the synthesis of bench‐stable boryl thianthrenium dicationi...
Irreversible Inversion of Circularly Polarized Luminescence via Magneto‐Thermal‐Induced Structural Reorganization in a Chiral Lead Bromide Crystal
Abstract The dynamic inversion of circularly polarized luminescence (CPL) in solid‐state materials is a pivotal goal for both fundamental science and advanced ch...
Insight into the Behavior of Interstitial Electrons in CuZn Alloy‐Functionalized Covalent Organic Framework Catalysts for Enhanced CO <sub>2</sub> Electroreduction
Abstract The development of application‐oriented, highly active, and selective CO 2 reduction reaction (CO...
Rigidifying Qubit Candidates in a Cu‐Porphyrin Nanohoop: Dipolar Coupling in Spin Pairs and Spin‐Polarized Ground State
Abstract Assembling molecular qubit candidates with precise control over the position and orientation of spin centers is an important contemporary challenge for...
Transmembrane Transport of cAMP and AMP Using a Two Component Small Molecule Transport System
Abstract Nucleotides such as cAMP (cyclic adenosine monophosphate) and AMP (adenosine monophosphate) are central to many cellular processes, but their highly hyd...
Dual‐Functional Additive Reshapes Lifetime Limit of Potassium‐Ion Batteries
Abstract Potassium‐ion batteries (PIBs) are being considered as the sustainable alternative to lithium‐ion systems, yet their specific energy and cycling lifespa...