Angewandte Chemie International Edition
Articles in this Issue
Electroenzymatic CO <sub>2</sub> Fixation
ABSTRACT Replacing fossil resources with renewable alternatives for chemical production requires highly integrated, energy‐efficient, and selective CO...
Generalized Analysis of Electrophilic Small Molecules
ABSTRACT Chemical construction almost universally employs highly customized product‐specific analytics. A transition toward generality will remove this critical bottleneck. Here we p...
Molecular Qubits for Anion Sensing by Tuning Electron Spin Relaxation via Axial Ligand Field
ABSTRACT Previously, we reported a new macrocyclic ligand, Mes N 6 , which enable...
Catalytic Functionalization of Unactivated π‐Bonds Enabled by Bidentate Directing Auxiliaries
ABSTRACT Catalytic functionalization of unactivated π‐bonds is a cornerstone of modern organic synthesis, offering efficient pathways to complex molecules. The emergence of the biden...
Enhanced CO <sub>2</sub> Activation Through Spin States Engineering Boosting Urea Electrosynthesis From Co‐Reduction of CO <sub>2</sub> and NO <sub>2</sub> <sup>−</sup>
ABSTRACT Electrocatalytic urea synthesis through co‐reduction of CO 2 and NO 3 −...
Incorporation of Novel Synthetic Glycolipids in Liposomal Nanoparticles Affects Opsonization and In Vivo Clearance
ABSTRACT Mimicking cell membrane glycocalyx, saccharide modification of nanoparticles offers a potent means to regulate their in vivo fate. Here, we investigate...
A Highly Strained All‐BODIPY‐Based Nanohoop
ABSTRACT Highly strained π‐conjugated nanohoops present significant synthetic challenges but offer interesting platforms for exploring unique physical properties...
Enantioselective Total Syntheses of Bisleuconothine A and Bousigonine B
ABSTRACT Hetero‐oligomeric monoterpenoid indole alkaloids (MIAs), which possess unique three‐dimensional architectures and relatively high molecular weights, are intriguing targets i...
Nickel‐Catalyzed Boron‐Mediated Saturative Trifunctionalization of Alkynes
ABSTRACT Converting simple alkynes into fully substituted alkanes—installing three distinct groups via a sequential one‑pot process—remains a formidable challeng...
Neutral X‐Site ABX <sub>3</sub> ‐Type Perovskites
ABSTRACT ABX 3 ‐type perovskite materials have garnered significant and sustained attention over the years owing to their...
Marker‐Agnostic Tumor Anchoring Chimeras Enable pH‐Gated Immune Engagement
ABSTRACT Targeted cancer immunotherapies typically depend on cell surface antigens to direct immune responses. However, many tumors either lack tumor‐specific markers or downregulate...
Copper‐Catalyzed Enantioselective C–H Phosphorylation Enabled by a 3,3’‐Difluorinated BINOL Ligand
ABSTRACT The asymmetric construction of C–P bonds via transition‐metal‐catalyzed enantioselective C–H activation remains a significant and unresolved challenge. Herein, we report an...
Synergistic Tuning of Structure and Active Phases in Zn–Mn Loaded Carbon Nanofiber Aerogel for High–Efficiency Desulfurization
ABSTRACT Hydrogen sulfide removal under mid–to–high temperature is one of the key technologies for the clean development of coal–based syngas, and its core lies...
Plutonium Gets a Cage
ABSTRACT Fellhauer et al. report the first plutonyl cage cluster, {Pu60}, marking a major advance in plutonium chemistry (DOI: 10.1002/anov.7...
Palladacarboxamide Capping Reagents for Carbon Isotope Labeling and Pharmaceutical Diversification
ABSTRACT Radiolabeling of bioactive molecules is essential for elucidating their pharmacokinetic and pharmacodynamic properties. Aryl carboxamides represent comm...
Potassium‐Ligand Cooperation Facilitated Chemical Bond Activation and Catalytic Hydrogenation
ABSTRACT Replacing conventional transition metals with main‐group elements for chemical bond activation and catalysis is of increasing interest, yet alkali metal...
Time‐Resolved Mapping of Interface Charge Transfer for Real‐Time Observation of Microscopic Chemical Reactions
ABSTRACT Real‐time monitoring of microscopic chemical reactions offers valuable insight into reaction mechanisms, intermediate species, and the reaction kinetics involved. Mainstream...
Reengineering Protease Inhibitors to Disrupt Hsp70 Chaperone Function
ABSTRACT The heat shock protein 70 (Hsp70) family consists of ATP‐driven molecular chaperones essential for maintaining protein homeostasis (proteostasis) across all cell types, howe...
Outside Back Cover: Electroenzymatic CO <sub>2</sub> Fixation (Angew. Chem. Int. Ed. 28/2026)
Selective Synthesis of 7‐/14‐membered Cyclic Carbonates by Temperature Gradient‐Assisted Depolymerization and Preparing High‐Performance Aliphatic Polycarbonate via Controlled Ring‐Opening Polymerization
ABSTRACT CO 2 /epoxide copolymerization and ring‐opening polymerization (ROP) of 6‐membered cyclic carbonate have been wi...
Outside Front Cover: Synergistic Tuning of Structure and Active Phases in Zn─Mn Loaded Carbon Nanofiber Aerogel for High‐Efficiency Desulfurization (Angew. Chem. Int. Ed. 28/2026)
DNA‐Induced Entropic Gain Triggers an Allosteric Switch for Biomolecular Condensation of Heat Shock Transcription Factor 1
ABSTRACT The molecular logic of how site‐specific DNA recognition by a transcription factor (TF) is transduced into macroscopic protein condensation remains a fundamental puzzle in c...
Inside Front Cover: Biocompatible Interface for Organic Electrochemical Transistors Enables Bioadhesion and Over‐Swelling Suppression (Angew. Chem. Int. Ed. 28/2026)
Constructing Superionic Heterointerface via Multiphase Engineering to Achieve Stable Oxyhalide‐Based All‐Solid‐State Batteries
ABSTRACT Amorphous oxyhalides attract great interest as solid‐state electrolytes (SSEs) in all‐solid‐state batteries (ASSBs) because of their oxidative stability...
Lattice‐S Regulation of CoOOH Spin State and Surface Microenvironment Enables High‐Activity, High‐Selectivity, Industrial‐Level Electrocatalytic Glycerol Upgrading
ABSTRACT Electrocatalytic upgrading of biomass‐derived glycerol into high value‐added formate presents significant energy and chemical application potential. Her...