Angewandte Chemie International Edition
Articles in this Issue
A Rigid and Strong Donor Strategy for Solution‐Processed Neat‐Film Near‐Infrared OLEDs Beyond 900 nm
ABSTRACT Near‐infrared (NIR) organic light‐emitting diodes (OLEDs) generally suffer from low external quantum efficiencies (EQEs). Conventional NIR thermally activated delayed fluore...
Reconstructing Solvation Chemistry via Cosolvent Regulation for Interfacial Engineering Toward Stable High‐Voltage O3‐Type Cathodes
ABSTRACT O3‐type layered oxides have emerged as promising cathode materials for sodium‐ion batteries (SIBs) due to their high reversible capacity. However, their...
Total Chemical Synthesis of Interleukin‐15 and Interleukin‐2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy
ABSTRACT Hydrophobic and aggregation‐prone proteins still present obstacles for protein chemical synthesis and engineering. The chemical synthesis of Interleukin...
Anisotropic NMR as a Crucial Tool for Differentiation of Epimers With High Conformational Flexibility
ABSTRACT Identifying the correct structures of epimers is highly challenging due to the sometimes very subtle differences in their respective NMR signatures. In...
High‐Entropy Polymer Electrode for Fast Rechargeable Batteries
ABSTRACT Polymer electrode materials possess the advantages of sustainability, abundant resources, and structural adjustability, yet suffer from poor rate capabi...
Nickel–Boryl‐Catalyzed Modular Alkyl Difluoromethylation Enabled by an NMP‐Stabilized ICF <sub>2</sub> H Reagent
ABSTRACT The difluoromethyl (CF 2 H) moiety is a privileged pharmacophore that imparts enhanced metabolic stability, lipo...
Organometallic Frameworks for Efficient Electrocatalytic CO <sub>2</sub> Reduction Reactions
ABSTRACT The electrocatalytic conversion of CO 2 to value‐added chemicals driven by renewable electricity offers a viable...
Fluorogenic Coupled Assays Reveal Catalytic Properties, Inhibition Constants and Cellular Location of Mucin‐Active Carbohydrate Sulfatases
ABSTRACT Sulfated glycans play a central role in human health and influence cell signaling, cancer progression, pathogen invasion, and host‐microbiome interactio...
Catalyst Hide‐and‐Seek Beneath Porous Support Surfaces: Pinpointing Active Site Distribution Through Resonance Energy Transfer
ABSTRACT Merging the high selectivity and efficiency of homogeneous catalysts with the recyclability of heterogeneous systems represents an attractive, industry‐driven concept that c...
Hierarchically Porous Multivariate COF Aerogel With Enhanced Diffusibility and Tailored Functionality for Highly Efficient Bromine Sequestration
ABSTRACT Elemental bromine, owing to its inherently toxic, corrosive, and volatile nature, poses a great threat to the environment and public health. In this reg...
Optimize Before You Synthesize—Enhancing the Ionic Conductivity of Li <sub>7</sub> SiPS <sub>8</sub> Using Bayesian Optimization
ABSTRACT Tetragonal is a superionic solid electrolyte, yet its Li ion conductivity suffers from the presence of an amorphous side phase. Attempts to optimize the ionic conductivity,...
Mechanistic Insight Into the Polymorph‐Dependent Photosalient Effect of a White Light or Two‐Photon Activated Photoreactive Molecular Salt
ABSTRACT The photosalient effect (PE) provides a visually striking demonstration of the direct transduction of light energy into macroscopic mechanical work. How...
Mesoporous N,S‐Dual‐Doped Carbon Nanoreactors via Entropy‐Driven Interface Self‐Assembly for Efficient H <sub>2</sub> O <sub>2</sub> Electrosynthesis
ABSTRACT The electrochemical two‐electron oxygen reduction reaction (2e − ORR) offers a sustainable route for H...
Stepwise Conformational Restriction of Acylhydrazone‐Based Molecules for High Signal‐to‐Noise Fluorescent Recognition of Synthetic Cannabinoid FUB‐INACA
ABSTRACT Establishing explicit correlations among material dimensionality, luminescent properties, and sensing performance is of critical importance for the rati...
Reprogramming NAD(P) <sup>+</sup> ‐Binding Proteins for Iminium Biocatalysis via a Synthetic NAD <sup>+</sup> ‐Type Cofactor
ABSTRACT Efficient integration of non‐natural catalytic motifs into protein scaffolds remains a central challenge in artificial enzyme design. Here we report ani...
Direct Photocatalytic Conversion of Methane to Acetone Through a Synergistic Ta Single‐Atom/Ga Lewis Acid Catalyst
ABSTRACT Direct photocatalytic conversion of methane to ≥ C3 oxygenates under ambient conditions remains highly challenging and largely unexplored due to the cur...
A Multifunctional Sulfur(VI) Fluoride for SuFEx Reactions: <i>N</i> ‐CF <sub>2</sub> H Sulfamoyl Fluorides
ABSTRACT Sulfur(VI) fluorides based on sulfur(VI) fluoride exchange (SuFEx) chemistry have demonstrated their unique versatility and high efficiency in the field...
Photocracking of Polystyrene into Aromatic Products in CH <sub>2</sub> Cl <sub>2</sub>
ABSTRACT Photocatalytic cracking of polystyrene (PS) into valuable aromatic chemicals presents a key route to plastic waste upcycling under mild conditions, in w...
W <sub>1</sub> /TiO <sub>2−</sub> <i> <sub>x</sub> </i> Enabled Photoelectrochemical Tandem Upgrading of Glycerol to Nucleoside Precursors
ABSTRACT Pentose aminooxazoline (PAO) is a key precursor in the synthesis of nucleoside and carbohydrate drugs. However, conventional PAO synthesis methods are h...
Self‐Optimization With Oriented Facet Reconstruction for Universal Electrocatalytic C–N Coupling
ABSTRACT Electrocatalytic C–N coupling represents a green synthesis platform, yet the dynamic evolution of catalyst surfaces during the reaction remains poorly u...
Hydrogenation of CO <sub>2</sub> to Methanol Catalyzed by In <sub>2</sub> O <sub>3</sub> : Oxygen Vacancies, Surface Hydroxyl Groups, and Temperature Dependence for Reactivity Revealed by <sup>17</sup> O NMR
ABSTRACT Catalytic hydrogenation of CO 2 over In 2 O 3...
DNA‐mimic for Specific Surface Functionalization of Zr‐MOFs for Bacterial Targeting
ABSTRACT Nanosized metal–organic frameworks (MOFs) are versatile platforms used in biomedical applications due to their high loading capacity, large surface area...
Nitrate‐Stabilized Cu <sup>δ+</sup> Sites Promote Selective CO <sub>2</sub> Electroreduction to Ethanol for Tandem Acetamide Electrosynthesis
ABSTRACT Electrosynthesis of acetamide, a multicarbon nitrogenous compound containing C─C─N bonds, from abundant CO 2 and...
Perilipin‐2‐Anchored Lipid Droplet‐Targeting Phototheranostics
ABSTRACT Conventional photothermal agents are readily taken up by normal cells, which may cause off‐target damage. Lipid droplet (LD) targeting can enable photot...
Geometric Nonuniformity Localizes Valence Orbitals in Gold Clusters: Case Study on [Au <sub>23</sub> (SC <sub>6</sub> H <sub>11</sub> ) <sub>16</sub> ] <sup>–</sup>
ABSTRACT To elucidate the effect of geometric nonuniformity on electronic structures of monolayer‐protected gold clusters, the valence orbitals of [Au...