Angewandte Chemie International Edition
Articles in this Issue
Electronic State Coupling for Cu <sup>+</sup> Stabilization to Boost Highly Efficient Transformation of CO <sub>2</sub> to C2 Products
ABSTRACT Cu‐based nanomaterials are attracting great attention for the electroreduction of CO 2 to valuable C2 products....
Long‐Acting Dynamic Therapy Using X‐Ray Activated Organic Nanoparticles for Afterglow Imaging Guided Deep Tumor Treatment
ABSTRACT Traditional dynamic therapies, including photodynamic, sonodynamic and chemodynamic therapies, are limited by shallow penetration and lack of sustained...
Water‐Mediated Phosphoryl Wires Stabilize Pathological Tau Fibrils
ABSTRACT Hyperphosphorylation of tau is a hallmark of tauopathies, with specific phosphorylation sites elevated in pathological fibrils. However, the molecular r...
Direct Synthesis of Polar Polyolefin Elastomers Enabled by Neutral Nickel‐Catalyzed High Temperature Solution Copolymerization
ABSTRACT Copolymerization of olefin and polar monomer to produce the desired polar polyolefin materials is a longstanding challenge, which becomes much more difficult when carried ou...
Hybridized Local and Charge‐Transfer Emitter With a Dual‐Hindered Indoline Donor for Fast and Efficient Red Plastic Scintillators
ABSTRACT Flexible organic red/NIR scintillators that convert ionizing radiation into long‐wavelength photons are intrinsically compatible with silicon photomulti...
Imine Linkage Isomerism in Layer‐Entangled Three‐Dimensional Covalent Organic Frameworks Modulates Fluorescent Sensing
ABSTRACT Three‐dimensional covalent organic frameworks (3D COFs) constructed from entangled two‐dimensional layers represent a rare yet intriguing structural cla...
Post‐Translational Isoaspartate Promotes Amyloid Formation in β <sub>2</sub> ‐Microglobulin
ABSTRACT β 2 ‐Microglobulin (β2m) aggregation is central to dialysis‐related amyloidosis (DRA), yet the molecular trigger...
A <sup>19</sup> F MRI/NIR‐FL Nanoprobe for “Turn‐On” Imaging of β‐Secretase (BACE1) Activity in Alzheimer's Disease
ABSTRACT Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder with very few therapeutic methods; thus, its early detection is urgen...
Advances in BODIPY Derivatives for Antibacterial Phototherapy
ABSTRACT The escalating threat posed by antibiotic‐resistant bacteria and biofilm‐associated infections has driven increasing interest in non‐antibiotic antibacterial strategies. Ant...
Catalytic Enantioselective Intramolecular Aza‐Michael Addition to α,β‐Unsaturated Esters
ABSTRACT A bifunctional iminophosphorane (BIMP)‐catalyzed enantioselective intramolecular aza‐Michael reaction of sulfonamides to tethered α,β‐unsaturated esters is described. Reacti...
Artificial Gap Junctional Channel Inhibiting the Proliferation of Hepatocellular Carcinoma Cells
ABSTRACT Gap junctions play a crucial role in intercellular communication, participating in both physiological and pathological processes. Although artificial gap junctions have been...
A Nonbenzenoid Nanographene Horse Saddle With Four Pentagon–Octagon Pairs
ABSTRACT The incorporation of non‐hexagonal rings into nanographenes (NGs) would significantly alter their geometry and electronic structures, unlocking new appl...
Chelator‐Free Radiometal Labeling Inside Engineered Affibodies
ABSTRACT Affibodies are remarkably stable three‐helix bundle proteins that can be engineered to selectively bind target proteins. When combined with radioactive...
Lithium–Nitrogen Battery: Promise and Development Roadmap
ABSTRACT Lithium–nitrogen (Li–N 2 ) batteries offer a unique electrochemical paradigm that combines intrinsically safe en...
Jerry Alfred Fereiro
Anionic T‐Shaped Platinum(0) Pincer Complexes and Platinum(I) Intermediates in Radical Reactions With Alkyl Halides
ABSTRACT Two anionic T‐shaped d 10 platinum(0) complexes supported by a sterically demanding carbazole‐based PNP ligand w...
Mg‐Mediated Dual Cross‐Electrophile Coupling of Propargyl and Allyl Dichlorides with Chlorosilanes: Access to Disilyl‐substituted Allene and Bis(Silyl)Propenes
ABSTRACT We have developed a novel strategy for synthesizing disilyl‐substituted allenes and bis(silyl)propenes using propargyl and allyl gem...
Enzyme‐Guided Assembly Enables Precision Delivery of a Singlet Oxygen Battery for Membrane Lipid Peroxidation Therapy
ABSTRACT Lipid peroxidation (LPO) of tumor cell membranes is a pivotal executor of regulated cell death and a potent trigger for antitumor immunity. However, most LPO inducing strate...