Angewandte Chemie International Edition
Articles in this Issue
Enhancing Waste Plastic Hydrogenolysis on Ru/CeO <sub>2</sub> Through Concurrent Incorporation of Fe Single Atoms and FeO <sub>x</sub> Nanoclusters
Abstract Ru‐based catalysts have exhibited significant promise in converting waste plastics into valuable long‐carbon chain products. However, their efficiency i...
In Situ “Confocal” Electrochemiluminescence 3D Imaging: From Cell to Tissue Section
Abstract Endowing electrochemiluminescence (ECL) imaging technique with three‐dimensional (3D) resolution to investigate specimens at varying axial depths poses...
Nanochanneling and Local Crystallization Engineering Accelerate Multiphase Single‐Atom Catalysis for Rapid Water Decontamination
Abstract Precise engineering of single‐atom catalysts (SACs) with optimal hierarchical structures and favorable local chemical environments remains a significant...
Enhancing C─C Bond Cleavage of Glycerol Electrooxidation Through Spin‐Selective Electron Donation in Pd–PdS <sub>2</sub> –Co <sub>x</sub> Heterostructural Nanosheets
Abstract As a 4 d transition metal, the spin state of Pd is extremely difficult to directly regulate for the optimized...
<i>closo</i> ‐Carboranyl Analogs of β‐Arylethylamines: Direct Synthesis from Alkenes via EnT‐Catalysis
Abstract closo ‐Carboranes are icosahedral carbon–boron clusters with unique properties and broad applicability. They particularly stand out...
Donor‐π‐Acceptor Photoinitiators for High‐Efficiency Visible LED and Sunlight Polymerization and High‐Precision 3D Printing
Abstract This study presents the development and evaluation of five dyes with varying conjugated energy levels and donor‐π‐acceptor (D‐π‐A) structures as photoin...
Restoring Cell–Cell Communication to Elicit Bystander Effect Using a DNA‐Based Nanocomplex for Robust Immunotherapy
Abstract The activation of the cyclic GMP‐AMP synthase‐stimulator of interferon genes (cGAS‐STING) pathway has shown promise in enhancing antitumor immunity. However, the pathway inv...
Rare Earth Single‐Atomic Hybrid Glasses for Near‐Infrared II Optical Waveguides
Abstract The increasing demands for modern information communication and storage necessitate the development of near‐infrared (NIR) active optical waveguides. Ho...
Design, Synthesis, and Application of a Family of Chiral Non‐C <sub>2</sub> ‐Symmetric NHCs with a Fused Sidechain
Abstract Although a considerable number of chiral nitrogen heterocyclic carbenes (NHCs) have been developed yet it is highly necessary to develop new NHCs bearin...
Plasmonic Ion Diode Membrane (PIDM) for Enhanced Nanofluidic Ion Transport
Abstract Efficient applications of nanofluidic devices are often limited by the insufficient ion permselectivity and inherent ion concentration polarization (ICP...
Helical Columnar Liquid Crystal Exhibiting Both Polarization Retention and Ferroelectric Switching at Room Temperature
Abstract Ferroelectric columnar liquid crystals (FCLCs) with switchable bistable axial polarizations are promising candidates for high‐density ferroelectric rand...
AI.zymes: A Modular Platform for Evolutionary Enzyme Design
Abstract The ability to create new‐to‐nature enzymes would substantially advance bioengineering, medicine, and the chemical industry. Despite recent breakthrough...
Lewis Acid Catalyzed Divergent Reaction of Bicyclo[1.1.0]Butanes With Quinones for the Synthesis of Diverse Polycyclic Molecules
Abstract Bicyclo[1.1.0]butanes (BCBs) are highly strained hydrocarbons with unique structural properties and intrinsic reactivity, making them valuable building blocks for constructi...
Bulk Measurement of Membrane Permeability for Random Cyclic Peptides in Living Cells to Guide Drug Development
Abstract Cyclic peptides are attractive for drug discovery due to their excellent binding properties and the potential to cross cell membranes. However, by far,...
On‐Membrane Supramolecular Assemblies Serving as Bioorthogonal Gating for Melphalan
Abstract Covalent drugs have experienced a revival in recent decades due to their advantageous pharmacodynamic profiles and targeting of “undruggable” proteins. However, balancing se...
Cobalt‐Catalyzed Asymmetric Hydrogenation of α‐Hydroxy Ketones Enabled by a Carboxylic Acid Additive Promotion Strategy
Abstract Highly enantioselective hydrogenation of α‐hydroxy ketones was achieved by applying the catalytic combination of cobalt acetate and chiral Ph‐BPE ligand...
Bayesian Meta‐Learning for Few‐Shot Reaction Outcome Prediction of Asymmetric Hydrogenation of Olefins
Abstract Recent years have witnessed the increasing application of machine learning (ML) in chemical reaction development. These ML methods, in general, require huge training set exa...
Tailored Polymer‐Zeolite Imidazolate Framework Membranes for Aperture‐Matched C4 Hydrocarbon Separation
Abstract The integration of metal‐organic frameworks (MOFs) with polymers for efficient C4 hydrocarbon separation membranes remains challenging, primarily due to...
Metal‐Controlled Enantiodivergent Tandem Rearrangement to Synthesize 2 <i>H</i> ‐Azirines
Abstract A metal‐controlled enantiodivergent rearrangement of α‐diazo‐β‐keto oxime ethers has been developed. Switching the metal catalyst from Co(II) to Fe(II)...
An Update: Enzymatic Synthesis for Industrial Applications
Abstract Supported by rapid technological advancements, biocatalytic applications have matured into sustainable, scalable, and cost‐competitive alternatives to e...
Decoupled MOF Breathing: Pressure‐Induced Reversal of Correlation Between Orthogonal Motions in a Diamondoid Framework
Abstract Responsive porous materials can outperform more rigid analogues in applications requiring precise triggering of molecular uptake/release, switching or g...
Metal‐Organic Cages Assembled From {Ni <sub>6</sub> } Nodes for Selective CO <sub>2</sub> Reduction
Abstract Constructing cluster‐based nodes and using them as catalytic sites can bring new structure and function for metal‐organic cages (MOCs). However, success...
Outside Back Cover: Benzotrifuran‐based Covalent Organic Frameworks for Artificial Photosynthesis of H <sub>2</sub> O <sub>2</sub> from H <sub>2</sub> O, O <sub>2</sub> and Sunlight (Angew. Chem. Int. Ed. 27/2025)
Topological Control Over Porphyrin‐Based Covalent Organic Frameworks for Elucidating Electron Transfer Characteristics
Abstract Two‐dimensional covalent organic frameworks (2D COFs) have emerged as promising functional materials due to their programmable architectures and tunable...
Simultaneous Improvement of Mechanical Strength, Toughness, and Self‐healability of Elastomers Enabled by F─H‐Bond‐Based Nanoconfinement
Abstract There are often trade‐offs among high mechanical strength, high toughness, and efficient self‐healing. Herein, we present a biomimetic strategy utilizin...