Angewandte Chemie International Edition
Articles in this Issue
Iron‐Doped Cobalt Molybdate Enhanced Electrochemiluminescence Imaging for Dynamic Multilevel Information Encryption System Construction and Biomarker Sensing Analysis
Abstract Integrating electrochemiluminescence (ECL) imaging with a multilevel information encryption strategy overcomes the limitations of conventional encryption methods, which rely...
Tailoring Zn‐ion Solvation Structures for Enhanced Durability and Efficiency in Zinc–Bromine Flow Batteries
Abstract Aqueous zinc‐bromine flow batteries (ZBFBs) are among the most appealing technologies for large‐scale stationary energy storage due to their scalability...
Inverted Chiroptical Properties of Hybrid Metal Halides Through Reversible Chiral Induction Driven by External and Internal Chirality Transfer
Abstract Chiral organic‐inorganic hybrid metal halides (OIHMHs) are commonly constructed by introducing pairs of enantiomorphic chiral precursors through a singl...
Surface Transformation in Lanthanum Nickelate for Enhanced Oxygen Evolution Catalysis
Abstract Nickel‐based perovskite oxides are identified as promising candidates for oxygen evolution reaction (OER) catalysts in view of their low cost, highly tu...
Engineering Bipolar Covalent Organic Framework Membranes for Selective Acid Extraction
Abstract Nitric acid (HNO 3 ) is a vital industrial chemical, and its recovery from complex waste streams is essential fo...
Synergistic Ru Species on Poly(heptazine imide) Enabling Efficient Photocatalytic CO <sub>2</sub> Reduction with H <sub>2</sub> O beyond 800 nm
Abstract Photocatalytic CO 2 conversion with H 2 O to carbonaceous fuels is a des...
Structural Basis for the Catalytic Mechanism of ATP‐Dependent Diazotase CmaA6
Abstract Although several diazotases have been recently reported, the details of the reaction mechanism are not yet understood. In this study, we investigated the mechanism of CmaA6,...
A Carboxylate‐based Hydrophilic Organic Photovoltaic Catalyst with a Large Molecular Dipole Moment for High‐Performance Photocatalytic Hydrogen Evolution
Abstract Achieving ultrafast dissociation of photogenerated excitons and efficient charge transport within the photocatalyst is a fundamental issue. Additionally...
Single‐Atom Fe Catalysts With Improved Metal Loading for Efficient Ammonia Synthesis Under Mild Conditions
Abstract Ammonia synthesis is a cornerstone in the chemical industry. Given that the traditional Haber–Bosch (H‐B) process requires very high temperature and pre...
Control over S(VI)‐Stereogenic Center: NHC‐Catalyzed Enantioselective Synthesis of <i>N</i> ‐Acyl Cyclic Sulfonimidamides
Abstract The catalytic enantioselective synthesis of aza‐sulfur(VI) compounds holds significant potential in pharmaceuticals owing to their broad spectrum of bio...
De Novo Design of Structure‐Tunable Multivalent Targeting Chimeras for Tumor‐Targeted PD‐L1 Degradation and Potentiated Cancer Immunotherapy
Abstract Targeted protein degradation (TPD) technology holds significant potential for modulating protein homeostasis and treating diseases. However, current methods for degrading me...
Macrocyclic Peptide Probes for Immunomodulatory Protein CD59: Potent Modulators of Bacterial Toxin Activity and Antibody‐Dependent Cytotoxicity
Abstract CD59 is an immunomodulatory cell surface receptor associated with human disease. Despite its importance in complement regulation and bacterial pathogenesis, CD59 remains a c...
Giant Birefringence Enabled by the Highly Anisotropic Linear IX <sub>2</sub> <sup>−</sup> (X = Cl, Br) Building Blocks
Abstract Birefringent crystals are essential for polarized optical devices, yet achieving large birefringence through rational design remains challenging. The ke...
Engineering a Proximity Biosensor via Constitutional Dynamic Chemistry
Abstract Affinity binding‐induced DNA assembly is a fundamental principle for designing proximity biosensors for sensitive and wash‐free protein detection and imaging. However, curre...
Boosting Electronic Charge Transport in Conductive Hydrogels via Rapid Ion‐Electron Transduction
Abstract Traditional design of conductive hydrogels involves embedding conductive components within a hydrated polymeric network to establish interconnected elec...
Front Cover: AI.zymes – A Modular Platform for Evolutionary Enzyme Design (Angew. Chem. Int. Ed. 27/2025)
Scalable Main Group Mechanocatalytic CO <sub>2</sub> Valorisation to Cyclocarbonate Species
Abstract Over the past two decades, main group elements have gained attention as promising substitutes for precious metals in catalytic processes. Additionally, mechanochemistry is e...
Direct Synthesis of Poly(adipate)Esters via Catalytic Isomerizing Dual Hydroesterificative Polymerization of 1,3‐Butadiene
Abstract Aliphatic polyesters, such as poly(adipate)esters, are attracting substantial attention as sustainable materials due to their degradability, recyclability, and versatility i...
Metal Complexes Stimulating Immunogenic Pyroptosis as Burgeoning Antitumor Strategy
Abstract The exploration of antitumor agents with diverse action mechanisms has become an important focus in both fundamental research and clinical oncology, driven by the need for m...
Masahiko Yoshimura
LC‐MS and High‐Throughput Data Processing Solutions for Lipid Metabolic Tracing Using Bioorthogonal Click Chemistry
Abstract Tracing lipid metabolism in mammalian cells presents a significant technological challenge due to the vast structural diversity of lipids involved in multiple metabolic rout...
Hyperpolarization Modulation of the T‐Type hCa <sub>v</sub> 3.2 Channel by Human Synenkephalin [1–53], a Shrew Neurotoxin Analogue without Paralytic Effects
Abstract Mammalian secreted venoms mainly consist of peptides and proteases used for defense or predation. Blarina paraly...
Correction to “Zinc Coordination‐Polymer‐Mediated Self‐Assembly of Nanoparticles into ‘Brick‐and‐Mortar’ Membranes for Hydrogen Separation”
Benzotrifuran‐Based Covalent Organic Frameworks for Artificial Photosynthesis of H <sub>2</sub> O <sub>2</sub> from H <sub>2</sub> O, O <sub>2</sub> , and Sunlight
Abstract Hydrogen peroxide (H 2 O 2 ) is an important green chemical and a potent...
Streamlining SuFEx Inhibitor Development: A Unified Approach Using Photolabile and Orthogonal Sulfinate Protecting Groups
Abstract Sulfonyl fluorides (SFs) have gained significant importance due to their classification as a click reaction and therefore have seen increased use in dru...