Angewandte Chemie International Edition
Articles in this Issue
Min‐Jae Choi
Spin Frustration Determines the Stability and Reactivity of Metal–Organic Frameworks with Triangular Iron(III)–Oxo Clusters
Abstract Density functional theory (DFT) is the standard approach for modeling MIL‐101(Fe) and related Fe‐based metal–organic frameworks, typically assuming a ferromagnetic high‐spin...
A Modular Three‐Component Asymmetric Tsuji–Trost Reaction Enabled by Cooperative Palladium/Lewis Acid Catalysis
AbstractAsymmetric allylic substitution (AAS) reactions, named as the Tsuji–Trost reaction, stand as a landmark in modern organic synthesis. The merge of AAS reactions with the concept of multicompone...
In Situ Click Chemistry Screen Facilitated by an On‐Nanoparticle DNA‐Encoded Library Identifies Highly Selective and Potent Peptoid Ligands for a Phosphatase
AbstractCapture agents that selectively bind to biological targets are indispensable tools in diagnostics, therapeutics, and biomedical research. However, discovering such capture agents, particularly...
Inside Front Cover: A Photoresponsive Hybrid of Viruses and Supramolecular Peptide Fibers for Multidimensional Control of Patterning and Infection (Angew. Chem. Int. Ed. 41/2025)
General Synthesis of 2D Mesoporous Multimetal Spinel Supracrystals for High‐Efficiency Electrochemical Applications
AbstractTwo‐dimensional (2D) mesoporous metal oxide crystals that integrate atomic‐level single crystallinity with ordered mesoporosity represent a promising but rarely realized class of materials, pa...
Inside Back Cover: Modeling Midbrain and Brainstem Neuromelanins to Characterize Metal Binding and Associated MRI Contrast in Parkinson's and Alzheimer's Diseases (Angew. Chem. Int. Ed. 41/2025)
Corral[<i>n</i>]Bicarbazoles: Redox‐Active Chiral Macrocycles for Air‐Stable Radical Cations Formation and Guest Capture/Release
AbstractMacrocyclic compounds are pivotal in both supramolecular chemistry and materials science, as their preorganized cavities enable selective molecular recognition, while their cyclic frameworks f...
Hydrophilic Iridium Bis‐<i>N</i>‐Heterocyclic Carbene Complexes Catalyze Linear‐Selective, Additive‐Free Hydroaminomethylation of Long‐Chain Olefins in Water
AbstractAqueous hydroaminomethylation (HAM) of olefins generally requires the use of organic solvents, additives, and high‐pressure hydrogen to synthesize amines in satisfactory yields and selectivity...
Correction to “A Hybrid Supramolecular Polymeric Nanomedicine for Cascade‐Amplified Synergetic Cancer Therapy”
A Photon‐Driven Unimolecular Immunostimulant for Self‐Amplified Pyroptosis and cGAS‐STING Pathway by Destroying the Pyroptosis Checkpoint
AbstractImmunotherapy is a groundbreaking approach for clinically treating tumors, but its effectiveness is hindered by the tumor's immunosuppressive environment and lack of immune cell infiltration,...
Tailoring the Oxygen Vacancy Distribution in Se‐Doped RuO<sub>x</sub> to Enhance Its Stability in Acidic Water Electrolysis
AbstractDeveloping durable ruthenium (Ru)‐based catalysts for proton exchange membrane water electrolyzer (PEMWE) remains challenging due to irreversible Ru dissolution and lattice oxygen instability....
Bionic Design of Ni<sup>4+</sup> Lewis Acid Site Based on Selective Seawater Oxidation
AbstractThe side reaction caused by chloride ions and the toxicity to the active site have always been the hindrance to the electrocatalyst of the oxygen evolution reaction (OER) for seawater splittin...
<i>N</i>‐Doped Nonalternant Nanoribbons with up to 29 Linearly‐Fused Rings and High Charge‐Carrier Mobilities
AbstractThe synthesis of nonalternant graphene nanoribbons (GNRs)—carbon‐based nanostructures featuring fused pentagonal or heptagonal rings that disrupt hexagonal symmetry—has remained a significant...
Highly Flexible Porous Aromatic Frameworks with Exceptional Adsorption Capacity Toward Volatile Organic Compounds
AbstractIn this work we report a novel strategy to enhance the adsorption capacity of conventional porous materials by engineering intrinsic framework flexibility into porous aromatic frameworks (PAFs...
Translational Supramolecular Thioorthoester Chemistry
AbstractSupramolecular chemistry promises that insights into contact between molecules will open up new directions to approach significant questions in science and society. In this spirit, Kraus et al...
Accessing Strain Engineered V‐Fe(O)OH from Prussian Blue Analogue Precatalyst for Efficient Anodic Oxidation Reactions
AbstractPrussian blue analogues (PBAs) are promising precatalysts to access active metal oxyhydroxide [M(O)OH] phases for anodic oxidation reactions (AORs). In this study, we have introduced a d‐d ele...
Multi‐Step Screening‐Guided Core‐Shell RuO<sub>2</sub>@TaO<sub>x</sub> Nanorods Electrocatalyst for Acidic Oxygen Evolution Reaction
AbstractIn the acidic oxygen evolution reaction (OER), the exploration of highly efficient and stable electrocatalysts is essential for the environmentally friendly production of hydrogen. Although Ru...
Quest for Luminescent Low‐Spin Chromium(I) Complexes with Doublet Metal‐to‐Ligand Charge‐Transfer Excited States
AbstractTwo paramagnetic Cr(I) complexes with homoleptic fac‐bis(triarylisocyanide) ligands were prepared by chemical oxidation of the Cr(0) precursors and emission spectra with peak maximum at respec...
Iron‐Catalyzed <i>trans</i>‐Hydrostannation of Terminal Alkynes
AbstractThe readily accessible iron complex [Cp*FeCl(tmeda)] is an effective catalyst for the highly regio‐ and stereoselective trans‐hydrostannylation of terminal alkyl alkynes, affording a type of a...
SuFEx‐Enabled Polypeptide: Creating Diversified Properties with Minimal Preset Conditions
AbstractFacile but effective synthesis and functionalization of polypeptides has long been a challenge, blocking the way to further explorations of their properties and potential applications. Here, w...
Non‐Fused Conjugated Alkylfluorene Bridged Naphthalimides Cathode Interlayer Enables Low‐Noise Near‐Infrared Organic Photodiodes
AbstractThe cathode interface layers (CILs) play a crucial role in enhancing the performance of organic photodiodes (OPDs). However, the poor film formation, the tendency of orientation and aggregatio...
HerTACs Enable Tumor‐Selective Lysosomal Degradation of Membrane and Extracellular Proteins via HER2 Trafficking
AbstractTargeting extracellular and membrane proteins for degradation remains a frontier challenge in the field of targeted protein degradation (TPD), largely due to the intracellular confinement of e...
Deciphering the Role of Fluorination in Dual‐Halogen Electrolytes for All‐Solid‐State Batteries: A Case Study of New Li<sub>2</sub>HfCl<sub>6−x</sub>F<sub>x</sub> Solid Electrolytes
AbstractLithium metal chlorides are promising superionic conductors for all‐solid‐state batteries (SSBs) due to their favorable mechanical properties, high ionic conductivity, and good oxidative stabi...
Topology‐Engineered Guide RNAs for Programmable Control of CRISPR/Cas Activity
AbstractCRISPR/Cas systems have transformed genome editing, yet achieving precise temporal and conditional control remains challenging. Traditional strategies involving linear guide RNAs (gRNAs) modif...