Angewandte Chemie International Edition

Bioinspired Anti‐Freezing Hydrogel With Localized Ice Regulation for Subzero Soft Robotics

AbstractFreezing hydrogels at subzero temperatures severely compromises mechanical flexibility, ionic conductivity, and structural integrity, thereby limiting their application in low‐temperature envi...

Outside Back Cover: Spin Frustration Determines the Stability and Reactivity of Metal–Organic Frameworks with Triangular Iron(III)–Oxo Clusters (Angew. Chem. Int. Ed. 41/2025)

Solvent‐Driven Precise Control of Stacking Configurations in Covalent Organic Frameworks for High‐Efficiency Photocatalysis

AbstractTwo‐dimensional covalent organic frameworks (2D COFs) have emerged as promising photocatalysts due to their high surface areas and precisely tunable physicochemical properties. However, it rem...

Outside Front Cover: Stereoselective Self‐Assembly of a Topologically Chiral [6]Catenane with 18 Crossings (Angew. Chem. Int. Ed. 41/2025)

Photocatalytic Formamide Synthesis from Plastic Waste and Ammonia via C─N Bond Construction Under Mild Conditions

AbstractPhotocatalytic upcycling of polyethylene terephthalate (PET) waste into value‐added chemicals represents a sustainable route for plastic valorization. However, previous studies have solely foc...

Organocatalytic Enantioselective [4 + 4] Cycloadditions of Furan <i>Ortho</i>‐Quinodimethanes

AbstractThe enantioselective [4 + 4] cycloaddition for the construction of cyclooctanoids is a challenging transformation in organic chemistry. Herein, we present the first organocatalytic enantiosele...

Node Flexibility Unlocks Structural Adaptability and Guest Versatility of Anionocages

AbstractDue to their exceptional nodal flexibility, anionocages are promising host molecules capable of mimicking the dynamic self‐assembly and host–guest chemistry of proteins. However, their applica...

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

AbstractThis review explores the potential of mechanochemistry in the late‐stage modification of active pharmaceutical ingredients (APIs), offering a comprehensive analysis of methods designed to tran...

Rapid and Modular Access to All‐Carbon Quaternary Center‐Containing 2,2‐Disubstituted Bicyclo[1.1.1]pentanes via Cyanocarbene Addition to Bicyclo[1.1.0]butanes

Abstract While 1,3‐disubstituted bicyclo[1.1.1]pentanes (BCPs) have garnered considerable interest in medicinal chemistry as bioisosteres of...

Phospholipid‐Drug Conjugates Self‐Organized into Well‐Defined Supramolecular Nanotubes for Efficient Drug Delivery

AbstractControlled self‐organization of amphiphilic phospholipid camptothecin (CPT) conjugates (named PCCs) selectively forms supramolecular nanotubes with varying lengths and polydispersity. Our stud...

Regioselective Separation and Extraction of Polyalkylthiophene by Metal–Organic Frameworks

AbstractHere, we report a novel method for selectively extracting high‐regioregularity (RR) poly(3‐hexylthiophene) (P3HT) from crude mixtures using metal–organic frameworks (MOFs) as nanoporous separa...

Umpolung Activation of Bicyclobutanes via N‐Heterocyclic Carbene Catalysis

AbstractBicyclo[1.1.0]butane (BCB) has predominantly been explored as an electrophile or radical acceptor owing to its inherent polarity. However, its reactivity as a nucleophile remains largely unexp...

Dynamic Molecular Triplet Excitons Tune Lanthanide Emission Lifetime

AbstractOptical codes generated from the emission lifetimes of lanthanide complexes have received considerable attention for their potential application in multiplexed bioimaging and anti‐counterfeiti...

Force‐Induced Ring Flipping in a Threaded Pillar[5]Arene

AbstractPillar[n]arenes are popular macrocycles used in various supramolecular systems and materials due to their unique host–guest properties and ease of synthesis. Their pillar shape originates from...

Optical Force Monitoring in Polymeric Materials with a Coumarin‐Based Mechanophore

AbstractOptical mechanophores offer a powerful platform for the real‐time, nondestructive detection of mechanically induced damage in polymers. However, the exploitation of mechanophores for fundament...

Probing Photoelectrochemical Hydrogen and Oxygen Evolution at Individual Al:SrTiO₃/Rh_2–yCr_yO₃ Photocatalyst Particles

AbstractParticle‐based photocatalysts for overall water splitting convert solar energy into hydrogen fuel without the use of any photovoltaic devices. As such they have the potential to revolutionize...

Mechanochemical Degradation of Polystyrene Into Benzene for Recycling and Upcycling

AbstractSynthetic plastics sourced from petroleum have gained widespread use since the 1950s. Polystyrene (PS) is one of the most extensively used plastics, as it is colorless, has high mechanical str...

Near‐Full‐Spectrum Emission Control in Copper(I) Iodides via Inorganic Structural Engineering Within a Single‐Cation Host

AbstractHybrid copper(I) halides have emerged as a new class of optoelectronic materials due to their tunable structure and photophysical properties. However, systematically correlating inorganic poly...

Molecular Afterglow of Lophine‐Based Luminophore and Its Imaging Applications

AbstractLophine, the first chemiluminescent compound discovered in history, has rarely been applied for in vivo imaging since its discovery in 1877. In this report, we demonstrate that lophine's chemi...

Bidirectional Hydrogen Spillover Enables High Activity Catalysts for Rechargeable Hydrogen Batteries

AbstractRechargeable hydrogen batteries exhibit superior electrochemical activity for hydrogen evolution and oxidation reactions (HER/HOR) in acidic media compared to alkaline counterparts, making the...

Boosting Nitrate‐to‐Ammonia Conversion over Copper‐Based Electrocatalysts by Facilitating Hydrogenation and Product Desorption

AbstractElectrocatalytic nitrate reduction reaction (NitRR) in neutral condition offers a sustainable route for ammonia (NH3) production and water purification. For the most extensively investigated C...

Lattice‐Engineered Lanthanide Nanocrystals with Tunable Near‐Infrared‐IIb Lifetime

AbstractLattice engineering in lanthanide nanocrystals (LnNCs) is fundamental for tailoring their versatile optical properties, yet it remains underexplored in manipulating the downconversion characte...

A Photoresponsive Hybrid of Viruses and Supramolecular Peptide Fibers for Multidimensional Control of Patterning and Infection

AbstractViruses are versatile colloidal materials in their biofunctions, monodispersed and periodic structures, and high surface designability. For expanding the applicability of virus‐based materials...

Considerations in Pursuing Reaction Scope Generality

AbstractThe term “generality” has recently been popularized in synthetic chemistry, owing largely to the increasing use of high‐throughput technology for producing vast quantities of data and the emer...

Volcano‐Shaped Relationship Between Interfacial K⁺‐H₂O Ratio and CO₂ Reduction Activity in Tandem Electrocatalysts

AbstractModulating surface‐active hydrogen (*H) supply represents a critical strategy to boost the electrocatalytic CO2 reduction reaction (ECRR), yet the mechanistic interplay between *H dynamics and...