Considerations in Pursuing Reaction Scope Generality

S Samson B. Zacate (Department of Chemistry and Chemical Biology) J Juliana A. Dantas (Department of Chemistry University of Utah Salt Lake City UT 84112 USA) S Song Lin A Abigail G. Doyle M Matthew S. Sigman

Abstract

AbstractThe term “generality” has recently been popularized in synthetic chemistry, owing largely to the increasing use of high‐throughput technology for producing vast quantities of data and the emergence of data science tools to plan and interpret these experiments. Despite this, the term has not been clearly defined, and there is no standardized approach toward developing a method with a diverse (general) scope. This minireview will examine different emerging strategies toward achieving generality using selected examples and aims to give the reader an overview of modern workflows that have been used to expedite this pursuit.

Article Details

Volume / Issue Vol. 64, Issue 41
Published October 06, 2025
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (5)

S

Samson B. Zacate

Department of Chemistry and Chemical Biology

J

Juliana A. Dantas

Department of Chemistry University of Utah Salt Lake City UT 84112 USA

S

Song Lin

A

Abigail G. Doyle

M

Matthew S. Sigman