Angewandte Chemie International Edition
Articles in this Issue
Zinc‐Coordinated Lipids: Facilitators for Enhanced mRNA Delivery Efficacy
Abstract The advancement of mRNA therapeutics necessitates more efficient delivery systems. Current clinically advanced lipid nanoparticles (LNPs) primarily bind mRNA through electro...
Frontispiece: Finding the Key: Binding of Metal‐Oxo Clusters to the Enzyme Active Site Enabled by “Click” (Bio)Conjugation
Quantitative Reactivity Profiling of Functional Arginine Residues in Human Cancer Cell Line Proteomes
Abstract Arginine, a critical amino acid for protein structure and function, is involved in enzyme catalysis and macromolecular interactions. However, selectivel...
Development of High Performance Pyrolized Polyimide‐based Carbon Molecular Sieves for Enhanced Selectivity of Propylene/Propane Gas Separation
Abstract The replacement or de‐bottlenecking of the highly energy‐intensive distillation unit operation process for propylene/propane separation has long posed a...
Frontispiece: Carbonothioate‐Triggered Cascade Cyclization Enables High‐Specificity Fluorescence Imaging of Hydrogen Polysulfides
Cyclometalated Gold(III)‐Mediated Cysteine Arylation: A Bioorthogonal Platform for Covalent Targeting of Intrinsically Disordered Proteins
Abstract Intrinsically disordered proteins (IDPs) remain largely inaccessible to covalent chemical tools due to their structural plasticity and lack of defined p...
Mechanochemically Induced Circularly Polarized Luminescence from Polymers
Abstract Achieving diversified optical signals in polymer mechanochemistry remains a significant challenge, particularly within the area of light polarization. T...
Precise Kinetic Separation of Hexane Isomers via Morphology Engineering of Metal–Organic Frameworks with Diffusion‐Selective Pore Structure
Abstract Hexane isomer separation is critical to advancing sustainable and high‐value refining in the petrochemical industry. However, precise separation of mult...
Superatomic or Not? A Case Study on Isostructural Au <sub>3</sub> Ag <sub>2</sub> and Au <sub>3</sub> Cu <sub>2</sub> Nanoclusters
Abstract Two bimetal nanoclusters, [Au 3 Ag 2 (Ppy 3...
Enantioselective Synthesis of Inherently Chiral Calix[4]arenes via Catalytic Asymmetric Lower‐Rim Functionalization
Abstract We report herein an efficient approach for the enantioselective synthesis of inherently chiral calix[4]arenes (ICCs) via chiral phosphoric acid (CPA)‐ca...
Closing Electron Transfer Loop to Boost Electrocatalytic Urea Synthesis
Abstract The electrocatalytic C─N coupling of carbon dioxide and nitrate presents a promising approach for environmentally friendly urea synthesis. In this work,...
Improving Oxygen Electroreduction Efficiency of Porous Silicon‐based Catalysts via Atomic Iron Site‐Induced Lattice Expansion
Abstract Developing non‐noble metal‐based catalysts as alternatives to precious metals for the 4 electron oxygen reduction reaction (ORR) in acidic conditions is...
Recent Advances in Regulating Metal−Silica Interaction for Boosting Heterogeneous Catalytic Performance
Abstract Heterogeneous catalysts are extensively utilized in the modern chemical industry, with catalytic processes primarily occurring on the surfaces of nanocr...
A Heterogenised Molecular Electrocatalyst for Round‐the‐Clock Green Hydrogen Production by Solar‐Electrolyser and Zinc–Air Batteries
Abstract Solar energy‐driven seawater electrolysis presents a sustainable method for producing high‐purity green hydrogen to address the energy crisis. Developin...
Reductive Cross‐Coupling of Alcohol Derivatives with Chlorosilanes via Pyridines‐Promoted Si─Cl Activation
Abstract The development of efficient approaches mediated by silyl radicals for constructing C─Si bonds is of great interest and importance, yet methods to generate these intermediat...
Side‐Chain Macrocyclization in Ahp‐Bicyclodepsipeptides Biosynthesis Involves Cytochrome P450‐Catalyzed Sequential Aromatic Hydroxylation and C─N Coupling
Abstract We report the biosynthesis of FR901277 ( 1 ) and delmomycin A2 ( 2 ), tw...
ATP‐Powered Signaling Between Artificial and Living Cells
Abstract ATP is the energy currency of life and is overabundant in the tumor microenvironment, where it has been suggested as a target for cancer therapy. We introduce ATP‐dissipativ...
Enzyme Immobilization in Porous Crystals via Cage Encapsulation
Abstract Enzyme immobilization within solid or polymer matrices continues to face challenges, such as inhomogeneous protein environments, low loading efficiency, and limited versatil...
Atroposelective Synthesis of Ultrarigid Chiral Styrenes via Pd‐Catalyzed Unconventional <i>5‐exo‐dig</i> Cyclization/Carbonylation of 1,5‐Enynes
Abstract Axially chiral styrenes represent a promising class of atropisomers with broad potential in asymmetric catalysis, drug discovery, and materials science....
Click‐Cyclized Cell Penetrating Peptides Containing Hydrophobic Proline Derivatives for Efficient Intracellular Delivery
Abstract Targeting intracellular organelles with macromolecules is challenging due to cell membrane impermeability. Innovative approaches to direct intracellular...
Catalytic Non‐Oxidative C–C Coupling of Benzene to Biphenyl Over Sub‐Nanostructured Europium Hydride
Abstract Catalytic coupling of benzene to biphenyl through direct C─H bond activation and C─C bond construction represents an ideal, atom‐economical strategy, of...
Unravelling the Dynamic Modulation of Copper (Oxy)Hydroxides for Electrocatalytic Organic Nucleophile Oxidation
Abstract Electrocatalytic nucleophile oxidation (NOR) is pivotal for renewable energy and sustainable synthesis, yet the ambiguous nature of active sites hinders...
The Parkinson's Disease Drug Tolcapone and Analogues are Potent Glycomimetic Lectin Inhibitors of <i>Pseudomonas aeruginosa</i> LecA
Abstract The notorious pathogen Pseudomonas aeruginosa relies on the lectin LecA for host cell adhesion, invasion, and bi...
Upcycling of Waste Plastics into Carboxylic Acids for Biodegradable Surfactants
Abstract This work outlines a process for producing high‐purity (>95%) carboxylate surfactants from post‐consumer recycled high‐density polyethylene (PCR‐HDPE). The approach invol...
Exploring a New Family of (Phosphinochalcogenoyl)Europocenes for Magneto‐Optical Thermometry
Abstract The development of novel materials based on lanthanide metallocenes remains a valuable endeavour, due to the synthetic accessibility, compositional tuna...