Angewandte Chemie International Edition
Articles in this Issue
Rational Crystal Contact Engineering for Programmable Self‐Assembled Protein Architectures
Abstract Ordered protein‐based assemblies are increasingly desirable for materials science, but the design of new materials remains challenging and requires considerable effort. Crys...
Valence‐Modulated Na <sub>4</sub> Fe <sub>3</sub> (PO <sub>4</sub> ) <sub>2</sub> (P <sub>2</sub> O <sub>7</sub> ) Cathode Tuned by Orbital‐Delocalization for Extreme‐Temperature Sodium Storage
Abstract Iron‐based polyanionic Na 4 Fe 3 (PO 4...
Dual‐Compatible Polarity‐switched Small Molecules Enable Auxiliary Charge Generation and Transport Pathways in Organic Solar Cells
Abstract The commercialization of organic solar cells (OSCs) is limited by bottlenecks including relatively high voltage loss, insufficient donor–acceptor interfacial charge generati...
Carbonothioate‐Triggered Cascade Cyclization Enables High‐Specificity Fluorescence Imaging of Hydrogen Polysulfides
Abstract Hydrogen polysulfides (H 2 S n ; n > 1) are critical redox signaling...
Difluorinative Cyclopropene Rearrangement by I(I)/I(III) Catalysis: Regio‐ and Stereoselective Synthesis of Allyl Difluorides
Abstract Allyl difluorides are pervasive in the pharmaceutical arena, but synthetic challenges in the construction of highly substituted derivatives impede chemical space exploration...
Palladium‐Catalyzed Enantioselective Three‐Component Dearomative Coupling of Bromoarenes: Modular Construction of Terpenoid Scaffolds
Abstract We report a palladium‐catalyzed asymmetric three‐component coupling of bromoarenes, diazoalkanes, and malonates. It represents a significant advancement...
Tough Supramolecular Glasses Enabled by Frustrated Non‐Covalent Complexation
Abstract Supramolecular glasses, as noncovalently cross‐linked amorphous materials, are hampered by a fundamental trade‐off between vitrification and mechanical performance. Here we...
Finding the Key: Binding of Metal‐Oxo Clusters to the Enzyme Active Site Enabled by “Click” (Bio)Conjugation
Abstract Molecular metal‐oxo nanoclusters with tunable redox and structural properties have emerged as powerful bio‐inorganic tools in catalysis, protein crystal...
Copolymer Sequence Regulation Enabled by Reactivity Ratio Fingerprints via Machine Learning
Abstract Sequence control is critical for tuning polymer properties in high‐end applications, where reactivity ratios serve as key parameters for analyzing and r...
Ruthenium‐Catalyzed Diversified Kinetic Resolutions of Diaryl‐Substituted Cyclobutenones via Asymmetric Transfer Hydrogenation
Abstract 1,2‐Diaryl‐3,4‐dialkyl cyclobutanes (DA 2 CBs) are important scaffolds in numerous bioactive substances. However...
Simultaneous Induction and Self‐Reporting of Nucleolar Stress by a Nucleolus‐Targeted Platinum(II) Complex via Lifetime Imaging
Abstract The nucleolus exhibits characteristic viscous fluid dynamics, whereas nucleolar stress plays a key role in carcinogenesis. However, monitoring nucleolar...
Conformational Quenching in an Engineered Lipocalin Protein Achieves High Affinity Binding to the Toxin Colchicine
Abstract The engineered lipocalin Colchicalin binds the clinically relevant plant toxin colchicine with picomolar affinity. X‐ray structures revealed major loop rearrangements at the...
In Situ NMR and Kinetics Reveal Origins of Regioselectivity Differences for Epichlorohydrin Ring‐Opening in Lewis and Brønsted Acid Zeolites
Abstract Altering the quantities and organization of reactive species at active sites enables control of turnover rates and regioselectivities (rate ratios) for...
Polyoxometalate‐Directed Assembly of Robust Coordination Cages: Overcoming Kinetic Inertness and Conformational Mismatch
Abstract The selective construction of kinetically robust coordination cages by self‐assembly remains a significant challenge in supramolecular chemistry. Herein...
Machine Learning‐Assisted Prediction of Ground‐ and Excited‐State Redox Potentials in Iridium(III) Photocatalysts
Abstract This study introduces a data‐driven framework that combines DFT calculations with machine learning to facilitate accurate and scalable predictions of ground‐ and excited‐sta...
A Synergistic Cu/Ca Dual‐Doping Strategy for High‐Stability and Fast‐Charging O3‐Type Cathode in Sodium‐Ion Batteries
Abstract The O3‐type layered oxide cathodes are highly promising for sodium‐ion batteries due to their high specific capacity. However, the sluggish kinetics and...
Inverting Palladium–Phosphorus Lewis Pair Formation: Phosphonium Acting as Z‐Type Ligand
Abstract Phosphorus‐based ligands are prototypical L‐type donors. Here, we introduce a Lewis acidic phosphonium cation that engages in unprecedented Z‐type coord...
Alternating Magnetic Field Induced Ultra‐Active Cu Sites in Trimetal‐Organic Frameworks for Low‐Overpotential CO <sub>2</sub> Electroreduction
Abstract The electrochemical CO 2 reduction reaction is a sustainable approach to address climate challenges, requiring e...
Solubility, Speciation and Thermodynamics of PuCO <sub>3</sub> OH(cr) in Carbonate Containing NaCl Solutions
Abstract The solubility, aqueous speciation, and solid phase formation of trivalent plutonium, Pu(III) was investigated for the first time in pH near‐neutral 0.1...
Redox Reactions with Calcium‐Metal Nanoparticles
Abstract Calcium is generally a highly reactive alkaline‐earth metal, but as bulk metal, it exhibits only low reactivity at ambient conditions due to small surfa...
Discriminative Peroxymonosulfate Activation on Iron Carbides for Redox‐Neutral Singlet Oxygen Generation
Abstract In conventional redox cycle‐based Fenton‐like processes, the imbalanced rates between the reductive activation of peroxymonosulfate (PMS) and the subseq...
Discovery of a Heme‐Dependent Enzyme Catalyzing Nitrogen–Nitrogen Bond Formation in Kinamycin Biosynthesis
Abstract A nitrogen–nitrogen (N─N) bond is a core feature of diverse natural products with interesting structural and biological properties. Kinamycin and lomaiv...
Spatial Confinement of Solution‐Inaccessible Single‐Site Cu(I) in a Molecular Titanium–Oxo Cage for Efficient Photo‐Electrocatalytic Urea Synthesis
Abstract We introduce a precisely engineered molecular titanium‐oxo cage, Ti 16 O 24...
Outside Front Cover: Deciphering Ball Milling Mechanochemistry via Molecular Simulations of Collision‐Driven and Liquid‐Assisted Reactivity (Angew. Chem. Int. Ed. 50/2025)
Solvent Channels and Electric Fields Guide Proton Delivery to the Active Site of Heme Peroxidases
Abstract The active sites of heme enzymes have evolved to control the formation of highly reactive intermediates in oxidative catalysis. Proton delivery to the heme is essential, yet...