Characterisation of the <i>N</i> ‐Methyltransferase <i>Sg</i> PsmC: Application in the Kinetic Resolution of Pyrroloindolines
Abstract
Abstract Many natural products and pharmaceutical compounds bear the pyrroloindoline scaffold, highlighting the importance of the heterocyclic motif. Here, we aim at expanding the toolset for the selective synthesis of pyrroloindolines by characterising and employing the N ‐methyltransferase Sg PsmC from Streptomyces griseofuscus , an enzyme involved in the biosynthesis of physostigmine, in a selective kinetic resolution of pyrroloindolines performed at a laboratory preparative scale.
Article Details
Authors (8)
Benjamin Panagiotis Chapple
Institute for Bioorganic Chemistry Heinrich‐Heine‐Universität Düsseldorf am Forschungszentrum Jülich Jülich 52426 Germany
Lia Nitz
Institute for Bioorganic Chemistry Heinrich‐Heine‐Universität Düsseldorf am Forschungszentrum Jülich Jülich 52426 Germany
Pascal Schneider
Birgit Henßen
Institute for Bioorganic Chemistry Heinrich‐Heine‐Universität Düsseldorf am Forschungszentrum Jülich Jülich 52426 Germany
Sebastian Myllek
Institute for Bioorganic Chemistry Heinrich‐Heine‐Universität Düsseldorf am Forschungszentrum Jülich Jülich 52426 Germany
Mona Haase
Institute for Bioorganic Chemistry Heinrich‐Heine‐Universität Düsseldorf am Forschungszentrum Jülich Jülich 52426 Germany
Thomas Classen
Institute of Bio‐ and Geosciences (IBG‐1: Bioorganic Chemistry) Forschungszentrum Jülich Jülich 52426 Germany
Jörg Pietruszka