Angewandte Chemie International Edition
Articles in this Issue
Perylene‐Diimide Dimers with Cross Conformations as Cathode Interfacial Layers for High‐Performance and Stable Thin‐Film Solar Cells
Abstract A series of PDI‐based monomers and cross‐coupled copolymers have been reported recently, exhibiting excellent photoelectric performance as cathode inter...
Terpenoid Synthesis via Convergent Radical Annulation
Abstract The development of a convergent radical annulation strategy for the synthesis of complex terpenoids from sclareolide is disclosed. This approach employs...
Electron‐Trap Induced “Hot” Microenvironment Boosting Photocatalytic Nitrogen Fixation
Abstract Plasmonic photocatalysis aims to develop a highly reactive surface enriched with hot carriers to enable challenging chemical processes, including high‐e...
Stereodivergent Construction of Spiropyrrolidine‐ <i>γ</i> ‐Butyrolactones Enabled by Cu/Ru Sequential Catalysis and Stereoselective Reduction
Abstract The stereodivergent synthesis of spiroheterocycles bearing multiple stereocenters is a pivotal yet challenging frontier in asymmetric catalysis, particu...
Rhodium(III)‐Nitroxyl Radical Complex Triggers Dual‐Pronged Disulfidptosis‐Apoptosis in Hepatocellular Carcinoma via Metabolic Sabotage and Redox Catalysis
Abstract Hepatocellular carcinoma (HCC) resists apoptosis‐targeting therapies, necessitating the development of agents targeting alternative cell death pathways....
The Histidine Kinase VraS Interacts with Vancomycin and Penicillins Through its Membrane‐Anchored N‐terminal Domain
Abstract Multidrug‐resistant Staphylococcus aureus ( S. aureus ) is a major globa...
Building Ligand‐Responsive Artificial Signaling Pathways Through Programmable <i>Trans</i> ‐Acting RNA Circuits in Mammalian Cells
Abstract Synthetic RNA circuits provide powerful tools to reprogram genetic networks for customized cellular functions. However, the construction of ligand‐induc...
Ferroptosis‐Impelled NIR Cyanine Dyes in Situ Generation Enabled Zero‐Background Fluorescence Imaging and Precise Surgical Tumor Excision
Abstract The diagnostic accuracy of fluorescence imaging enabled lesion site visualization and pathological biomarker quantification is often compromised by non‐specific probe activa...
Autocatalytic Circular DNA Powered Plasmonic CRISPR/Cas12a Platform for Ultrasensitive Non‐Nucleic Acid Target Sensing
Abstract CRISPR/Cas12a‐based detection of non‐nucleic acid targets faces two major challenges: 1) limited sensitivity due to the inherent inability to pre‐amplify non‐nucleic acid ta...
Transforming Inorganic Nitrate to Organic Nitriles by the pH Swing Effect in a Pickering Emulsion Electrocatalytic System
Abstract Electroreduction of nitrate to ammonia is attracting increasing attention. However, the purification and storage of low‐concentration ammonia generated...
A Chemically Engineered Macrocyclic Peptide Shuttle Overcomes Blood‐Brain Barrier in Aging Brain
Abstract The blood‐brain barrier (BBB) poses a major challenge for the delivery of therapeutics into the central nervous system. Receptor‐mediated transcytosis (RMT) is a highly effi...
Ir/TiO <sub>2</sub> Heterojunctions with in Situ Defects and Surface Plasmon Resonance: Chloride‐Resistant Catalyst for the Photocatalytic Hydrogen Evolution from Seawater
Abstract Photocatalytic seawater splitting for hydrogen production emerges as a promising sustainable approach to alleviate energy crises and global warming. How...
Enhanced‐Type Quantitative Luminescence Recognition for Per‐ and Polyfluoroalkyl Substances (PFAS) by a Metal–Organic Framework Single Crystal
Abstract Rapid and quantitative detection of per‐ and polyfluoroalkyl substances (PFAS) remains a critical challenge in environmental monitoring due to their low light absorption cap...
Chiral Bifacial Non‐Fullerene Acceptors with Chirality‐Induced Spin Selectivity: A Homochiral Strategy to Improve Organic Solar Cell Performance
Abstract Asymmetric design has emerged as an effective strategy to enhance the performance of non‐fullerene acceptors (NFAs) in organic solar cells (OSCs). Altho...
The Redox Properties of Polyphenols and Their Role in ROS Generation for Biomedical Applications
Abstract Polyphenols, particularly catechols, represent a significant class of compounds characterized by their versatile physicochemical and biological properties, sourced from both...
Covalent Activation of the C‐type Lectin DC‐SIGN
Abstract Dendritic cell‐specific intercellular adhesion molecule‐3‐grabbing non‐integrin (DC‐SIGN) is a C‐type lectin receptor expressed on antigen‐presenting cells, crucial for path...
Polarized Heterojunction in a Doubly Doped Layer‐by‐Layer Structure to Obtain an Organic Photovoltaic Device of 20.5% Efficiency
Abstract Achieving efficient double doping in organic photovoltaic (OPV) devices is hindered by parasitic interactions between p‐ and n‐type dopants, which lead...
Solvation‐Competing Nitrile Polymer Gel Electrolyte for High‐Voltage Quasi Solid State Lithium Metal Batteries
Abstract The search for Li‐ion batteries offering increased energy, power, and safety has led researchers to develop solid‐state Li batteries (ASSB) and more rec...
Inside Back Cover: Chiral Bifacial Non‐Fullerene Acceptors with Chirality‐Induced Spin Selectivity: A Homochiral Strategy to Improve Organic Solar Cell Performance (Angew. Chem. Int. Ed. 3/2026)
Synergistically Activating N <sub>2</sub> and CO <sub>2</sub> at Water Microdroplet Interfaces
Abstract Nitrogen (N 2 ) fixation is essential for sustaining life but is challenging under ambient conditions. Industria...
Synthesis of Chlorine‐Terminated MXenes by Dry Selective Extraction with TiCl <sub>4</sub>
Abstract Despite rapid research progress in the field of MXenes over the past decade, this new family of nanomaterials still faces challenges in terms of scalabl...
Revolutionizing Quinoidal Optoelectronics Through Heterojunction Engineering for Tri‐Modal Reconfigurability Wide‐Spectral Detection
Abstract Quinoidal‐conjugated materials are notable for their ultra‐low LUMO levels (<−4.0 eV) and exceptional wide‐spectral absorption in the NIR‐II region,...
Inside Front Cover: Brain‐Targeted Near‐Infrared Chiral TeSe Nanodrug Against Orthotopic Drug‐Resistant Glioma (Angew. Chem. Int. Ed. 3/2026)
Zn(II)‐Catalyzed Enantioselective Nucleophilic Substitution Reactions: Access to Sulfur(VI)‐Stereogenic Sulfonimidate Esters
Abstract The construction of stereogenic S(VI) centers remains a formidable challenge in asymmetric catalysis, despite incremental advances. The enantioselective...
Confining Reaction Intermediates in Oxide‐Derived Hollow Cu–Zn Bimetallic Catalyst Facilitates Selective Formation of C <sub>2+</sub> Alcohols from Electrochemical Carbon Dioxide Reduction
Abstract Copper has long been the only element known to produce multicarbon (C 2+ ) products from CO...