Angewandte Chemie International Edition
Articles in this Issue
Ionizable Nano‐PROTAC Overcomes Endosomal Entrapment for Enhanced LRG1 Degradation and Tumor Suppression
Abstract Nanoscale proteolysis‐targeting chimeras (nano‐PROTACs) have emerged as a promising modality that circumvents conventional linker optimization using mul...
Synergistic Dual‐Single‐Atom Catalysis Driving Auto‐Catalytic Process Toward Oxidant‐Free Fenton‐Like Chemistry for Water Purification
Abstract Driving oxidant‐free catalysis toward green and efficient Fenton‐like chemistry for water purification has been developed as a research hotspots of priority concern. In this...
Enantioselective Synthesis of H‐Phosphinamidates
Abstract Enantioenriched heteroatom‐containing H‐phosphoryl compounds unite a nucleophilic H–P(O) moiety with an electrophilic, substitutable heteroatom group, endowing them with inh...
Indole‐Linkages as Base‐Activated Sites in a Covalent Organic Framework for Efficient Photosynthesis of Hydrogen Peroxide Under Alkaline Conditions
Abstract The photocatalytic production of hydrogen peroxide (H 2 O 2 ) under alka...
Chlorine‐Enabled Double Borylation Strategy for π‐Extended MR‐TADF Emitters: From Synthetic Challenge to Benchmark OLEDs
Abstract Thermally activated delayed fluorescence (TADF) materials are promising emitters for organic light‐emitting diodes (OLEDs) owing to their ability to har...
Engineering Anionic Aggregation in Dilute Electrolyte for High Performance Layered Oxide Cathodes for Sodium‐Ion Batteries
Abstract Sodium‐ion batteries (SIBs) have garnered increasing attention due to their distinctive advantages. However, they still confront a series of technical c...
Pre‐Activation as a Route for Tuning the Kinetics of Mechanochemical Transformations
Abstract Learning to control reaction kinetics is essential for translating any chemical technology into real‐world application. Based on time‐resolved in situ p...
Molecular Symmetry and Geometry Engineering for High‐Temperature Ferroelectricity and Low Coercive Field in Hybrid Metal Halides
Abstract Optimizing ferroelectric properties is critical for molecule‐based ferroelectrics toward practical applications, including enhanced saturation polarizat...
Outside Front Cover: Solution ALD of (CH <sub>3</sub> NH <sub>3</sub> )(PbI <sub>3</sub> ) Perovskite Thin Films Yields Functional Quality and Stability Superior to Classical Processing (Angew. Chem. Int. Ed. 3/2026)
Supramolecular Carbohydrate Assemblies with Tunable Glycan Surfaces
Abstract The self‐assembly of molecular building blocks into ordered supramolecular structures enables the creation of nanomaterials that can display ligands on...
Reversible Monoclinic Transition Buffering and Stepwise Uniform Delithiation in Ni‐Rich Layered Cathodes
Abstract Ultrahigh‐Ni layered oxides are promising high‐energy cathodes but suffer from severe structural degradation during cycling, particularly due to irrever...
Stable Binuclear Platinum(II) Emitters with Substituted 2‐Hydroxypyridine Bridging Ligands for Red and Near‐Infrared OLEDs with EQE up to 32% and LT <sub>95</sub> up to 26 250 h at 1000 cd m <sup>−2</sup>
Abstract Platinum(II) metal–metal‐to‐ligand charge transfer ( 3 MMLCT) emitters have high radiative decay rates and tunab...
Tracking Structural and Electron Spin Density Changes in a Cooperative Mn <sup>3+</sup> Spin Crossover Complex at Atomic Scale via Low Temperature Solid‐State NMR
Abstract Electron spin‐state changes in transition‐metal (TM) complexes underpin many biochemical processes and molecular spin‐control technologies. Such transit...
Mixed‐Ligand‐Induced Crystal Symmetry Breaking and Lattice Distortion in Hybrid Cu(I) Halides for Near‐Unity Quantum Yield Scintillators
Abstract Cu(I)‐based metal halides have emerged as promising scintillators due to their efficient self‐trapped exciton (STE) emission. However, the radiative eff...
Crystalline 90°‐Twisted Carbon‐Centered Non‐Kekulé Diradical Derived from N‐Heterocyclic Carbene
Abstract Diradicals, molecules with two unpaired electrons, are crucial for understanding chemical reaction mechanisms, bond formation, and bond dissociation. Be...
Cobalt‐Catalyzed Deoxygenative Coupling of Ethers to Alkanes
Abstract Alkanes have extensive applications in diverse fields and their natural abundance is dwindling. Ethers are prevalently present in biomolecules and synth...
Enantioselective Syntheses of Secondary Alkylboronates via Asymmetric Regioselective Reduction of 1,3‐Dienylboronates
Abstract We report herein the development of catalytic asymmetric synthesis of secondary alkylboronates. Under the optimal conditions, Cu‐catalyzed semi‐reductio...
Synthetic Motifs for Understanding Lewis Acid Interactions with Persulfides and Thioselenides
Abstract Persulfides (RSS – ) and thioselenides (RSSe – ) play important roles in...
Manipulating P States of Organophosphine Polymers to Enhance Multi‐Channel Synergetic Room‐Temperature Phosphorescence
Abstract According to El‐Sayed's rule, nπ * component would facilitate intersystem crossing (ISC) and room‐temperature ph...
A Label‐Free Phosphate‐Transfer DNAzyme for the Cost‐Effective Point‐of‐Care Detection of Influenza Virus
Abstract DNAzymes have significantly enriched the toolbox for point‐of‐care testing (POCT); however, their inferior biostability and reliance on costly chemical labeling limit their...
Engineering Multicellular Inter‐Communication Systems Using a Synthetic Conformation Inducible Kinase Receptor
Abstract Synthetic multicellular inter‐communication systems are essential for understanding multicellular behaviors and developing cell‐based therapeutics. Synthetic receptors that...
Inner‐Axial Chlorine Engineering Enables Efficient and Selective Phenol Electrocatalytic Upcycling to Benzoquinone on Noble‐Metal‐Free Catalysts
Abstract Electrocatalytic upcycling of aqueous phenol into value‐added para ‐benzoquinone ( p...
Molecular Design of Nitrile Electrolytes Enabling Lithiated Silicon–Sulfur Batteries with Quasi‐Solid‐State Sulfur Reaction
Abstract The development of lithium–sulfur (Li−S) batteries is hindered by the polysulfide dissolving, cross‐over and the inherent lithium metal anode instabilit...
CO/H <sub>2</sub> S Dual Prodrugs Activated by Proximity‐Enhanced Chemiexcitation for Suppression of Tumor Growth and Metastasis
Abstract Carbon monoxide (CO) and hydrogen sulfide (H 2 S) both exhibit significant therapeutic potential in antitumor th...
Radiation‐Responsive Coacervates Through Controlled Self‐Immolative Demembranization
Abstract Coacervates formed through liquid–liquid phase separation (LLPS) have been utilized to emulate the dynamic organization of membraneless organelles in biological systems. The...