Angewandte Chemie International Edition

Dual‐Function Zinc Modulation Stabilizes Ru Clusters on Spinel Oxide for Efficient and Durable Acid Water Oxidation

Abstract The development of low ruthenium (Ru)‐based anodes with high activity and durability is crucial and still a challenge for proton exchange membrane water...

Seawater Electrosynthesis of Hydrogen Peroxide at Industrial‐level Current Densities Enabled by Pentagonal Defect‐Rich Nanocarbon with Chlorine Doping

Abstract The electrosynthesis of hydrogen peroxide (H 2 O 2 ) via two‐electron ox...

Deactivation of Single‐Atom Catalysts by Nanoparticles

Abstract Single‐atom catalysts (SACs) represent a pinnacle of atomic efficiency and catalytic precision. Their remarkable activity and selectivity arise from isolated, low‐coordinate...

Engineering Cyanoarene Photocatalysts to Resolve Deactivation Challenges in Organocatalyzed ATRP

Abstract Cyanoarene‐based photocatalysts (PCs) have been widely utilized in organic transformations including photo‐mediated controlled radical polymerization (C...

Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders

Abstract Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties. The biologically relevant chemical space defined by this unique nat...

Copper‐Silver Bimetallic Metal‐Covalent Organic Frameworks with Unique Intermediate Interlayer Transfer Effects for Enhanced Electrocatalytic CO ₂ to Ethylene Conversion

Abstract The electrochemical reduction of CO 2 to ethylene (C 2 H...

In‐Situ Spatial Visual Proteomics Enabled by Single‐Cell‐Type Proximity Biotinylation and Signaling Amplification

Abstract Mapping the spatial proteome signature within heterogeneous tissue microenvironment of clinical specimens offers unique insights into both physiological and pathological mol...

Electro‐Thermal Coupling Catalysis

Abstract The chemical industry serves as a cornerstone of modern societal development, yet it is also associated with substantial energy consumption and high emissions. Electro‐therm...

Highly Diastereo‐ and Enantioselective Pd‐Catalyzed Spiroaminoalkylation: One‐Step Construction of Multifunctional Angular Polycyclic Amines

Abstract Angular polycycles are ubiquitous in natural products with significant biological properties. However, the straightforward catalytic asymmetric synthesis of spirocyclic scaf...

Outside Back Cover: Rhodopsin‐Mimicking Reversible Photo‐Switchable Chloride Channels Based on Azobenzene‐Appended <i>Semiaza</i> ‐Bambusurils for Light‐Controlled Ion Transport and Cancer Cell Apoptosis (Angew. Chem. Int. Ed. 3/2026)

Streamlined Sugar Diversification via Photoredox‐Catalyzed Regio‐ and Stereoselective 1,2‐Alkylarylation of Glycals

Abstract Multi‐site modification of sugars represents a highly promising strategy for constructing bioactive molecules in glycosciences. However, the modular ass...

From Heat to Electrons: Bridging Heterogeneous Liquid‐Phase Thermal and Electrocatalytic Oxidation of Ethylene Glycol over Co ₃ O ₄

Abstract The selective oxidation of alcohols under thermal and electrocatalytic conditions presents a promising route to value‐added chemicals using sustainable...

Copper‐Catalyzed Enantioselective Radical Desymmetrizing Cyclization of Cyclopentenes: Access to Chiral 2‐Azabicyclo[2.2.1]Heptan‐3‐ones

Abstract We herein report an unprecedented copper‐catalyzed enantioselective radical desymmetrizing cyclization of cyclopentenes through peroxidation‐amination and alkylamination. Th...

Integrating Fluorinated [BF ₄ ] Anion With π‐Conjugated Six‐Membered Rings for Short‐Wavelength UV Frequency Conversion

Abstract Nonlinear optical (NLO) crystals for the short‐wavelength ultraviolet (UV) region are vital for all‐solid‐state lasers, particularly for generating 266 ...

From Methane to Nanodiamond Precursors in Water: Superacid‐like Condensation Pathways Under Extreme Conditions

Abstract The chemical behavior of water and hydrocarbons under extreme pressures and temperatures lies at the heart of processes shaping planetary interiors, inf...

Electrochemical Shortcut Denitrification Coupled with Chemical Diazotization for Low‐Carbon Nitrate Wastewater Treatment

Abstract Efficient treatment of nitrate (NO 3 − ) wastewater with low carbon emission is a tough chal...

Mono‐Materials Created by Engineering a Continuum of P3HB Stereomicrostructures in a One‐Step Catalytic Process

Abstract Multi‐material products that combine multiple complementary polymers can create products with desired performance but present challenges to end‐of‐life...

In Cellulo Peptide Cyclization via Gene‐Encoded Proximity‐Induced Proline‐Isothiocyanate Crosslinking

Abstract Cyclic peptides represent a very useful modality in modern drug discovery. However, there remain substantial technical challenges in the de novo biosynt...

Anion‐Shielded Porous Organic Cages for High‐Performance Xenon/Krypton Separation

Abstract The separation of Xe and Kr poses a significant industrial challenge. Herein, we demonstrate an anionic shielding strategy that effectively spatially co...

Turning Superparamagnetic Nanoparticles Into Ferromagnetic at Room Temperature via Molecular Functionalization for Magnetic Memory Applications

Abstract Molecular functionalization of magnetic oxide nanoparticles presents a powerful strategy for interfacial engineering, enabling the emergence of exotic m...

Constructing Robust Hydrogen Bond Networks in Electrolytes for Long‐Life Zinc‐Ion Batteries

Abstract Hydrogen bonding in the aqueous electrolyte of zinc‐ion batteries is a key factor dominating cycling stability due to the corrosive effects of water on...

Self‐Catalyzed Exothermic Binder Enables Ultrafast Processing and Migration‐Resistant Binder Networks for High‐Performance Lithium Battery Cathodes

Abstract Scalable manufacturing of high‐performance cathodes is crucial for next‐generation lithium‐ion batteries (LIBs). However, conventional binders such as p...

Heterogeneously Catalyzed Depolymerization of Polyurethane for the Efficient Recovery of Polyol and Dianiline

Abstract Polyurethane (PU) recycling remains a significant challenge owing to its inherent stability and crosslinked nature. Conventional chemical recycling meth...

Brain‐Targeted Near‐Infrared Chiral TeSe Nanodrug Against Orthotopic Drug‐Resistant Glioma

Abstract Glioblastoma multiforme (GBM) remains a formidable therapeutic challenge due to its high invasiveness, the highly restrictive blood–brain barrier (BBB),...

Inverse CO ₂ ‐C ₂ H ₂ Separation on the Low‐Silica CHA Zeolite Through Cooperative Cation and Gas Molecule Migration Mechanism

Abstract Inverse CO 2 /C 2 H 2 separation...