Circulation
Articles in this Issue
Abstract 4369860: Deep Learning Segmentation for Automated Measurement of Infarct Size in Preclinical Myocardial Infarction Models
Introduction: Myocardial infarct size (IS) is the most robust endpoint for evaluating cardioprotective strategies in preclinical ischemia/reperfusion studies. The gold standard for...
Abstract 4345502: Effect of Caloric Restriction on Cardiovascular-Kidney-Metabolic Health in Young Adults: Insights from the CALERIE Trial
Background: Cardiovascular-kidney-metabolic (CKM) health impairments are common among young adults in the US and contribute to premature morbidity and mortality, but the extent to...
Abstract 4363483: Global Burden of Ischemic Heart Disease Attributable to Particulate Matter: A GBD 2021 Analysis by Sociodemographic Index and Region (1990–2021)
Introduction: Ischemic heart disease (IHD) is a leading contributor to morbidity and mortality worldwide. Exposure to particulate matter has emerged as a major risk factor for isch...
Abstract Sun1006: Transcriptomic Analysis of Mitochondrial DNA-Induced Immune Cell Activation in a Porcine Model of Post-Cardiac Arrest Syndrome
Objective: Post-cardiac arrest syndrome (PCAS) is characterized by a rapid, dysregulated inflammatory response that exacerbates organ injury and undermines recovery. Mitochondrial...
Abstract 4368380: FYCO1 ameliorates postischemic cardiac remodeling by amplifying autophagic flux and inhibition of proinflammatory pathways
Background: Myocardial infarction (MI) triggers transcriptional responses that drive inflammation, metabolic changes and adverse cardiac remodeling. Enhanced autophagic flux is kno...
Abstract 4342105: Impact of frailty on in-hospital outcome of STEMI hospitalization: Analysis of National Inpatient Sample
Background and Purpose: National data and trends on the impact of frailty on ST-segment elevation myocardial infarction (STEMI) are lacking....
Abstract 4346591: Cardiovascular Diagnoses Following Smartwatch Irregular Pulse Notifications: Insights from the Apple Heart Study
Background: Atrial fibrillation (AF) is a leading cause of cardiovascular morbidity and mortality, and early detection is important for stroke prevention. The Apple Heart Study (AH...
Abstract 4369748: Race Differences in Acute Chest Pain Care in a Multisite U.S. Cohort
Introduction: Race-based differences in cardiovascular care are well described. However, data examining differences in cardiac testing and death or myocardial infarction (MI) rates...
Abstract 4337942: Prognostic Value of Unipolar and Bipolar Low Voltage Areas in Predicting Outcomes After Ventricular Tachycardia Ablation in Patients with Non-Ischemic Cardiomyopathy and Heart Failure
Background: Non-ischemic cardiomyopathy (NICM) patients with heart failure (HF) undergoing ventricular tachycardia (VT) ablation are at risk for long-term HF events. Left ventricul...
Abstract 4366420: Epicardial Adipose Tissue Biomarkers Are Associated with Myocardial Perfusion in Women with Angina and No Obstructive Coronary Artery Disease: A CMR study
Background: Angina with no obstructive coronary artery disease (ANOCA) is common in women and often linked to coronary microvascular dysfunction (CMD). Epicardial adipose tissue (E...
Abstract 4370196: Evaluating Aldosterone Synthase Inhibitors in Hypertension: A Meta-Analysis of Efficacy, Safety, and Subgroup Outcomes Across Novel Agents
Background: Hypertension remains a leading risk factor for cardiovascular disease and mortality. Aldosterone, a critical mineralocorticoid hormone, regulates salt, water balance, a...
Abstract 4344995: Prognostic value of cardiac computed tomography delayed enhancement in individuals with post-acute sequelae of COVID-19
Introduction/Background: Post-acute sequelae of COVID-19 (PASC) have been recognized as serious complications of SARS-CoV-2 infection. Despite considerable progress in understandin...
Abstract 4363123: Spinal Cord Injury Alters the Abundance of Proteins Associated with High-Density Lipoprotein
Background: Individuals with spinal cord injury (SCI) have 3x the odds of heart disease and 4x the odds of stroke compared to age and sex-matched able-bodied people. This elevated...
Abstract 4362656: Antithrombotic Strategies and Outcomes in Neonates and Infants with Cardiac Shunts: A Systematic Review and Meta-analysis
Background: Cardiac shunt thrombosis in neonates and infants remains a concern for shunt failure and mortality. Thromboprophylaxis for the prevention of shunt thrombosis is not an...
Abstract 4364027: ANDES-CHD-AI study: A New algorithm DEtectS critical Congenital Heart Disease using Artificial Intelligence at different altitudes
Background: Critical congenital heart disease (CCHD) screening algorithms based on pulse oximetry have up to 27% false positive rate at high altitudes (>2500 m) despite altitude...
Abstract 4358574: Assessment of Guideline-Recommended Treatment Times for ST-Elevation Myocardial Infarction Across Critical Access Hospital Networks
Background: ST elevation myocardial infarction (STEMI), characterized by complete coronary blockage, remains acutely lethal despite medical advances, with mortality rates unchanged...
Abstract 4367403: A Hidden Threat: Trazodone-Induced Warfarin Failure Leading to Acute Mechanical Aortic Valve Thrombosis
Background: Warfarin remains essential for preventing thrombosis in patients with mechanical heart valves. However, its narrow therapeutic index and susceptibility to drug interact...
Abstract 4342337: Cardiovascular, Kidney, and Metabolic (CKM) Syndrome is associated with increased risk for arrhythmia recurrence following atrial fibrillation (AF) ablation
Background: The concept of CKM syndrome reflects our evolving understanding that cardiovascular disease, including AF, is intricately connected to other systemic conditions....
Abstract 4370543: External Outflow Graft Obstruction in Left Ventricular Assist Devices: A Multimodality Imaging Approach to Diagnosis and Management Planning
Background: Innovations in left ventricular assist device (LVAD) technology have led to improved survival with less complications, however external outflow graft obstruction (EOGO)...
Abstract Sat603: Benchmarking the Impact of Out-of-Hospital Cardiac Arrest Treatment on All-Cause Mortality in the United States
Introduction: Our understanding of the epidemiology of out-of-hospital cardiac arrest (OHCA) has increased with the establishment of national registries. However, the use of EMS-tr...
Abstract 4365512: The Reproductive Experience of U.S. Women with Congenital Heart Disease: A Report from Congenital Heart Disease Project to Understand Lifelong Survivor Experience (CHD PULSE)
Background: While there are known pregnancy risks associated with congenital heart disease (CHD), it is unclear how this may affect reproductive decision making among adult women....
Abstract 4363666: A Comprehensive Study on Machine Learning Models Combining with Oversampling for One-year Persistent Coronary Artery Aneurysm in Kawasaki Disease
Background: Coronary artery aneurysm (CAA) is a major adverse cardiac complication of Kawasaki Disease (KD). Besides, persistent CAA serves as a risk factor for myocardial infarcti...
Abstract 4363041: Left Atrial Myopathy Associated with Mitral Annular Calcification: The Atherosclerosis Risk in Communities (ARIC) Study
Background: Left atrial (LA) myopathy and mitral annular calcification (MAC) are increasingly prevalent in the older adults. Limited data exist on the association between impaired...
Abstract 4367541: Mortality Implications of Cardiovascular-Kidney-Metabolic Syndrome Stage 3 Classification Based on Coronary Artery Calcium Score Cut-Offs: Insights from Pooled Multi-Ethnic Population Cohorts
Introduction: Cardiovascular-Kidney-Metabolic (CKM) Syndrome Stage 3 is associated with higher mortality than earlier stages. Current criteria upgrades Stage 1 and 2 to Stage 3 sol...
Abstract 4367950: Intensive lifestyle intervention, MASLD, and cardiovascular outcomes in type 2 diabetes and overweight or obesity: the Look Action for Health in Diabetes (Look AHEAD) trial Liver Ancillary Study
Introduction: Lifestyle modification with weight loss is recommended in type 2 diabetes (T2D) with metabolic dysfunction-associated steatotic liver disease (MASLD). However, the ef...