Circulation
Articles in this Issue
Intracellular TRPM7-Mediated Zn <sup>2+</sup> Release: A Novel Pyroptotic Axis in Myocardial Ischemia-Reperfusion Injury
The Fontan Outcomes Network: Findings After 2 Years and 1121 Participants
BACKGROUND: Survival after Fontan palliation for single ventricle heart disease has improved substantially, yet the long-term trajectory remains poorly defined. The Fontan Outcomes...
Nonoptimal Temperature and Cardiovascular Health: A Scientific Statement From the American Heart Association
Ambient temperature is a key environmental driver of cardiovascular health. With rising global temperatures and increasing frequency, intensity, and duration of extreme temperature events, understandi...
Response by Gasperetti et al to Letter Regarding Article, “Prognostic Role of Myocarditis-Like Episodes and Their Treatment in Patients With Pathogenic Desmoplakin Variants”
Letter by Luo et al Regarding Article, “Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults”
Inflammatory Hot Phases and Disease Trajectory in Desmosomal Cardiomyopathies
Response by Mori et al to Letter Regarding Article, “Screening-Detected Atrial Fibrillation and Cardiovascular Outcomes in Working-Age Adults”
Letter by Chen et al Regarding Article, “Prognostic Role of Myocarditis-Like Episodes and Their Treatment in Patients With Pathogenic Desmoplakin Variants”
Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial
BACKGROUND: Premature atrial contractions (PACs) are independently associated with atrial fibrillation, stroke, and heart failure, yet no pharmacological therapy is approved for PA...
Macrophage PRMT9 Ameliorates Acute Myocardial Infarction by Promoting Symmetric Dimethylation and Degradation of STAT1
BACKGROUND: During myocardial infarction (MI), M1-like macrophages exacerbate myocardial injury by excessively secreting inflammatory cytokines. Therefore, modulating the activity...
Pressure Overload–Induced Ventricular Crosstalk Activates Regenerative Mechanisms in the Contralateral Ventricle in Neonatal Mice
TRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn <sup>2+</sup> Homeostasis
BACKGROUND: Ischemic heart disease is one of the leading causes of death worldwide. Timely reperfusion is necessary for myocardium salvage but triggers parad...