Circulation
Articles in this Issue
Abstract 4362737: Incidence and Predictors of Atrial Fibrillation After Cavotricuspid Isthmus Ablation for Typical Atrial Flutter
Background: Cavotricuspid isthmus (CTI) ablation is a highly effective intervention for the treatment of typical atrial flutter (AFL). The emergence of new-onset atrial fibrillatio...
Abstract 4366505: Transcatheter Aortic Valve Replacement Adoption Reduces Surgical Aortic Valve Replacement Utilization and Expands Access to Aortic Valve Replacement in Hawaii from 2012–2023
Introduction: Transcatheter percutaneous aortic valve replacement (TAVR) was FDA-approved as an alternative to surgical aortic valve replacement (SAVR) in high (2012), intermediate...
Abstract 4369461: Circulating Androgen Precursors and Cardiovascular Risk: Insights From NHANES 2017-2023
Background: Androgen precursors such as 17α-hydroxyprogesterone, androstenedione, and dehydroepiandrosterone (DHEA) play significant roles in endocrine and metabolic pathways, yet...
Abstract 4367870: The Effectiveness and Outcomes of Atrial Fibrillation Ablation versus Medical Therapy in Patients with LVEF >35%: A Systematic Review and Meta-Analysis
Background: Atrial fibrillation (AF) ablation remains an essential therapeutic approach for patients who present with reduced left ventricular ejection fraction (LVEF); however, fi...
Abstract 4369443: ATTR-CM in the U.S.: Patterns of Healthcare Use and Medical Costs
Objective: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive heart disease caused by deposited amyloid fibrils, leading to stiffening of the heart muscle. Due to the...
Abstract 4365891: PCSK9 inhibitors increase CD34+ but not other endothelial progenitor cells in patients with stable coronary heart disease and increased Lp(a) values
Background: Endothelial dysfunction is an independent predictor of cardiovascular events in patients with established atherosclerosis, while the concentration of endothelial progen...
Abstract 4366666: Selective Degradation of NIMA-related kinase 7 (NEK7) via a Molecular Glue Degrader Inhibits IL-1 Downstream of NLRP3 Inflammasome Activation: A Novel Therapeutic Approach for Cardiovascular Inflammation
Background: Inhibition of IL-1 is a safe and effective treatment of recurrent pericarditis. However, the currently available agents are administered subcutaneously and there are no...
Abstract 4359239: Impact of Escalating Lipid-Lowering Therapy on Coronary Artery Calcium Progression and Lipid Biomarkers
Background: Coronary artery calcium (CAC) progression is a surrogate marker of atherosclerosis; however, the extent to which it can be modified by intensive lipid-lowering therapy...
Abstract Sat206: Differences in Cerebral and Somatic Hemodynamics during Asphyxia and Cardiac Arrest and Associations with Return of Spontaneous Circulation
Introduction: We have developed non-invasive optical devices for concurrent monitoring of cerebral and somatic hemodynamics using frequency-domain diffuse optical spectroscopy (FD-...
Abstract 4371473: Patient trust in physicians and disease understanding impact heart failure care in an urban safety-net health system
Introduction: Trust in physicians and disease understanding are important drivers of treatment adherence and outcomes across various chronic conditions. Little is known specificall...
Abstract 4360977: Tissue-Transducer Contact Sensing Improves High-Intensity Ultrasound Catheter Ablation in Healthy Swine
Background: High-intensity ultrasound (HIU) catheter ablation produces deeper lesions than radiofrequency and may serve as a new modality for interventricular septal (IVS) reductio...
Abstract 4361609: Loss of Adipose Lipophagy Impairs Lipid Mobilization and Exacerbates Obesity-Associated Metabolic Dysfunction
Introduction: As of 2024, nearly 75% of U.S. adults were overweight or obese, conditions marked by overaccumulation of lipid in adipose tissue that impairs health. Obesity is a maj...
Abstract 4357286: Atorvastatin and Pulse Wave Velocity in Anthracycline-based Chemotherapy
Background: Increased aortic stiffness is associated with cardiovascular morbidity and mortality, and is an adverse effect of anthracyclines. To date, there is no evidence-supporte...
Abstract 4363315: Dual Resolution of Brady- and Tachyarrhythmia via Left Atrial Appendage Ablation
Intermittent high-grade atrioventricular (AV) block is a rare bradyarrhythmia in the young. In the absence of structural conduction system disease, it may result from heightened vagal tone. We present...
Abstract 4347671: Concurrent Right Coronary and Sinus Node Artery Aneurysms with Right Atrial Fistula in a Young Adult: A Case Report
Case: A 23-year-old non-smoking male with no comorbidities or trauma history presented with one year of exertional dyspnea. Physical exam and initial workup (CXR, EKG, CBC, BMP, BN...
Abstract 4347966: High Use of P2Y12 Inhibitors and DOACs Persists up to One Year After Percutaneous Left Atrial Appendage Occlusion
Background: Percutaneous left atrial appendage occlusion (pLAAO) is used as an alternative to anticoagulation in patients with atrial fibrillation. Long-term patterns of antiplatel...
Abstract 4341110: Digital Heart Health: Improving Coronary Heart Disease Outcomes Through an Interactive Avatar Application
Introduction: Timely recognition and appropriate response to heart attack symptoms are critical in Coronary Heart Disease (CHD). Educational strategies that promote self-care may i...
Abstract 4368541: Three-Dimensional Echocardiographic Evaluation of Tricuspid Regurgitation Associated with Cardiovascular Implantable Electronic Devices
Background: Cardiovascular implantable electronic devices (CIEDs) are increasingly utilized to manage cardiac rhythm disorders and improve patient outcomes. However, their placemen...
Abstract 4363091: Gene Expression Profiles in Patient Specific IPSC-Derived Cardiomyocytes and Cardiac Fibroblasts with Laminopathies Across Diverse Patient Phenotypes
Introduction: Pathogenic variants (PVs) in the LMNA gene are associated with a range of diseases called laminopathies. While PVs in...
Abstract 4371748: Can the presence of vascular endothelial dysfunction be a prognostic factor for vasospastic angina?
Backgrounds: Vascular endothelial dysfunction (VED) is considered one mechanism underlying the development of vasospastic angina (VSA). However, the prognostic impact of VED on VSA...
Abstract 4366542: Trends and Demographic Disparities in Ventricular Septal Defects-related Mortality Among the United States Population, 1999-2023
Background: Ventricular Septal Defects (VSDs) are the most common congenital heart defect in children, affecting about 1 in 500 newborns in the United States, and are the second mo...
Abstract 4366327: Diagnostic Yield and Clinical Impact of Routine Genome Sequencing in Cardiovascular Patients
Introduction/Background: Cardiovascular disease (CVD) is the leading cause of death for American adults and has a multifactorial onset including genetic factors. However, there is...
Abstract 4369882: Transcatheter Tricuspid Valve Intervention plus Optimized Medical Therapy versus Optimized Medical Therapy Alone in Tricuspid Regurgitation: A Systematic Review and Meta Analysis
Background: Tricuspid regurgitation (TR) disease has a high incidence and prevalence. and while optimized medical therapy (OMT) helps with symptoms, it may be inadequate in severe...
Abstract 4363598: Is Age Just a Number? A Nationwide Multicenter Analysis of Post-Ablation Safety in Elderly Atrial Fibrillation Patients
Background: Evidence regarding the safety profile of atrial fibrillation (AF) catheter ablation remains limited. As life expectancy increases, a rising number of elderly patients a...
Abstract Sun1302: Supporting High Schools in Implementing CPR Training: The Ohio CPR in Schools Program
Background: The Ohio CPR in Schools program aims to help schools meet state requirements for CPR training before high school graduation. The program uses a “train the trainer” mode...