Circulation
Articles in this Issue
Abstract 4358809: Clinical characteristics and management of patients with hypertension and cardiovascular-renal-metabolic diseases in routine care: Insights from iCaReMe Global Registry
Background: Hypertension (HTN) is the leading modifiable risk factor for the global burden of cardiovascular renal metabolic diseases (CVRM). It’s a major precursor and comorbidity...
Abstract 4365438: Identification of heart failure patients by seismocardiography; a comparison with brain natriuretic peptide
Background: Heart failure is a significant global health concern, with limited diagnostic tools for efficient, cost-effective, and non-invasive detection. While echocardiography is...
Abstract 4372776: Electrical and mechanical dyssynchrony in pre-capillary pulmonary hypertension without complete bundle branch block: a comparison between electrocardiogram and two-dimensional echocardiography
Background: This study focused on exploring the correlation between the electrical and mechanical dyssynchrony of the right ventricle (RV) in pre-capillary pulmonary hypertension (...
Abstract 4365524: Racial and Ethnic Disparities in the Utilization of Mechanical Circulatory Support for Cardiogenic Shock Following Acute Myocardial Infarction
Background: Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) carries high morbidity and mortality. Mechanical circulatory support (MCS) devices are critical in...
Abstract 4367121: Functional Characterization of a Novel Natriuretic Peptide Receptor 1 Variant I751N Uncovers a New Mechanism of Blood Pressure Regulation
Introduction: Natriuretic peptide receptor 1 (NPR1) is a membrane-bound guanylate cyclase activated by atrial and brain natriuretic peptides (ANP and BNP), playing a central role i...
Abstract 4357784: Deep Learning-Based Retinal Biomarker Captures Cardiovascular Risk in Hypertensive Abnormal Dippers Beyond Conventional Metrics
Introduction: Among hypertensive subtypes, abnormal dippers — including non-dippers and risers — are characterized by blunted nocturnal blood pressure (BP) declines and are associa...
Abstract 4372869: Sedentary Behavior and Physical Health Status Explain the Relationship Between Years of Residence in Socioeconomically Distressed Counties and Risk for Cardiovascular Diseases
Background: Residents of rural socioeconomic distressed counties, such as Appalachian Kentucky, experience disproportionately high cardiovascular disease (CVD) risk, compounded by...
Abstract 4358019: The Impact of Neighborhood and Built Environment on Cardiovascular Health
Background: Cardiovascular disease (CVD) has remained the leading cause of death in the United States (US) for over a century. Despite progress in identifying risk factors and trea...
Abstract 4372348: Characterization and Prognostic Implications of Pulmonary Hypertension on Right Heart Catheterization Among Patients with Myeloproliferative Neoplasms
Background: Myeloproliferative neoplasms (MPNs), including essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF), are chronic leukemias associated with car...
Abstract 4346001: Diastolic Dysfunction in Coronary Microvascular Disease is Linked to Impaired Diastolic Wave Intensity
Background: Coronary microvascular disease (CMD) may be endothelium-independent (coronary flow reserve, CFR < 2.5) or endothelium-dependent (<50% increase in coronary blood f...
Abstract 4346565: The inhibition of ATP citrate lyase prevents pathological cardiac fibrosis via the regulation of de novo lipogenesis and histone acetylation
Background: Cardiac fibrosis is characterized by excessive extracellular matrix deposition in heart tissue that occurs early in heart failure (HF) and is caused not only by cardiac...
Abstract 4369925: Brain and Cardiovascular Connection in Recovery: Coupling Neurovascular Regulation to Vascular and Non-cardiac Inflammation in the Individual Patient Post Acute Myocardial Infarction
Background: How the human body coordinates cerebral blood flow (CBF) and multi-organ inflammation during recovery of an acute myocardial infraction (AMI) is difficult to study and...
Abstract 4358155: Coronary Microvascular Dysfunction Related to Disease Severity in Patients with Transthyretin Amyloid Cardiomyopathy
Background: The importance of coronary microvascular dysfunction in heart failure and cardiomyopathies is attracting attention. However, the significance of coronary microvascular...
Abstract 4365699: Liver fibrosis as assessed by the fibrosis-5 (FIB-5) index in patients with heart failure: Insights from the PARADIGM-HF and PARAGON-HF trials
Background: By causing systemic venous congestion and hypoperfusion, heart failure can lead to liver dysfunction and these processes along with neurohumoral activation, inflammatio...
Abstract 4369256: Patterns of genetic testing in fetuses and neonates with hypoplastic left heart syndrome are highly variable among centers in North America: A Fetal Heart Society collaborative study
Background: In research cohorts, pathologic genetic variants have been reported in nearly 30% of children with hypoplastic left heart syndrome (HLHS). However, reports of real-worl...
Abstract 4365366: Genetic Heart Rate Reduction Promotes Cardiac Regeneration in Adult Mice
Introduction: Elevated resting heart rate (RHR) is an established independent risk factor for cardiovascular disease. Cardiomyocyte (CM) metabolic flexibility is critical for cardi...
Abstract 4370556: SGLT2 Inhibitors Are Associated with Improved Outcomes in HFpEF Patients with ESRD
Introduction: Heart failure with preserved ejection fraction (HFpEF) commonly coexists with end-stage renal disease (ESRD, together increasing cardiovascular risk [1,2,3,4,5]. Whil...
Abstract 4361582: Artificial Intelligence-Enabled Electrocardiogram for Screening Asymptomatic Left Ventricular Systolic Dysfunction in Health Check-Up Populations
Background: Asymptomatic left ventricular systolic dysfunction (LVSD) often precedes overt heart failure but frequently goes undetected in the general population. With the rise of...
Abstract Sun305: Complications of Extracorporeal Membrane Oxygenation (ECMO) and Their Impact on Mortality, Length of Stay, and Hospital Costs: A National Inpatient Sample Analysis from 2018–2022
Background: Extracorporeal membrane oxygenation (ECMO) is a life-saving support for refractory cardiopulmonary failure. However, complications such as acute kidney injury (AKI), di...
Abstract 4368948: Eicosapentaenoic Acid (EPA) Limits Lipoprotein(a) Oxidation and its Related Effects on Endothelial Cell Stress Response Protein Expression
Background: Elevated lipoprotein(a) (Lp(a)) levels are causally and independently associated with increased cardiovascular (CV) risk. EPA administered as icosapent ethyl (IPE) redu...
Abstract 4369072: Impact of Percutaneous Mitral Valve Repair on Atrial Fibrillation Burden in Patients with Mitral Regurgitation
Introduction: Transcatheter Edge to Edge Repair (TEER) of the mitral valve is offered to severely symptomatic patients with mitral regurgitation (MR) and high or prohibitive surgic...
Abstract 4345278: Association of Hospital Shock Center Level with In-Hospital Outcomes in Cardiogenic Shock: An Analysis of the Nationwide Readmissions Database
Background: Patients with cardiogenic shock (CS) have high in-hospital mortality. Regionalized systems of care, modeled after trauma and ST-segment-elevation myocardial infarction...
Abstract Sun1207: Association of Emergency Medical Services Utility and Outcomes of Out-of-Hospital Cardiac Arrest in Young Adults and Pediatric
Introduction/Background: Out-of-hospital cardiac arrest (OHCA) in children and young adults is uncommon but devastating. While the etiology of OHCA shows unique features at each ag...
Abstract 4370200: High Prevalence of Autism Spectrum Disorder in Children Undergoing Heart Transplantation
Introduction and Objectives: Children with congenital heart disease (CHD) have an increased risk for autism spectrum disorder (ASD) compared to the general population, with a highe...
Abstract 4368245: Feasibility and Utility of Large Language Models Based on DeepSeek-R1 and ChatGPT-4o for the Interpretation of Cardiac Magnetic Resonance Reports: A Real-World Pilot Study
Background: Large language models (LLMs) serve as a promising tool for interpreting cardiac magnetic resonance (CMR) reports into more accessible language for patients, due to thei...