Circulation

Nuclear eNOS Interacts With and <i>S</i> -Nitrosates ADAR1 to Modulate Type I Interferon Signaling and Endothelial Function

BACKGROUND: Nitric oxide (NO), generated by the endothelial NO synthase (eNOS), regulates vascular tone and endothelial homeostasis to counteract vascular inflammation. Most eNOS i...

Short-Term Anticoagulation Versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure: The ANDES Randomized Clinical Trial

BACKGROUND: The optimal antithrombotic treatment after transcatheter left atrial appendage closure (LAAC) remains to be determined. The objective of this trial was to compare antic...

Challenges of Clinical Trials in Cardio-Oncology: Navigating Surrogate Outcomes and Identifying Patients at Risk of Late Cardiovascular Complications

Coronary Artery Revascularization in the Older Adult Population: A Scientific Statement From the American Heart Association

The United States is facing a demographic shift as the population of older adults grows rapidly, with the proportion of Americans ≥65 years of age projected to double by 2060. This aging trend will ha...

Sacubitril-Valsartan for the Prevention of Anthracycline Cardiotoxicity in Patients With Elevated Cardiac Troponin I Concentration During Chemotherapy: A Double-Blind Randomized Placebo-Controlled Clinical Trial: The SARAH Trial

BACKGROUND: The clinical effects of sacubitril-valsartan, an angiotensin receptor-neprilysin inhibitor, on anthracycline-induced cardiotoxicity remain unknown. Experimental evidenc...

Late-Breaking Science Abstracts and Featured Science Abstracts From the American Heart Association's Scientific Sessions 2025 and Late-Breaking Abstracts in Resuscitation Science From the Resuscitation Science Symposium 2025

Letter by Hang et al Regarding Article, “An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress”

A Common Ancestry-Specific Sodium Channel Variant Increases Susceptibility to Drug-Induced QTc Prolongation: Evidence From a Large Biobank

Response by Balligand and Michel to Letter Regarding Article, “An NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress”

Linearity in Regression Models: Meaning, Implications, and How to Handle it

Quantitative Identification of High-Risk Tricuspid Regurgitation by Cardiac Magnetic Resonance

BACKGROUND: The role of cardiac magnetic resonance (CMR) quantification of tricuspid regurgitation (TR) to identify high-risk patients with TR remains poorly defined. The aim of th...