Circulation
Articles in this Issue
Abstract 4370559: Second Harmonic Generation Microscopy to Assess Cardiac Fibrosis Changes in a Murine Model of Non-Ischemic Heart Failure
Introduction: Heart failure (HF) is characterized by maladaptive changes leading to excessive fibrosis. Delineating the extent of cardiac fibrosis and its specific composition can...
Abstract 4366454: Association of Race with Disease Expression and Clinical Outcomes among Patients with Mitral Valve Prolapse
Background: We do not clearly understand racial differences in risk profile, cardiac echocardiographic metrics among mitral valve prolapse (MVP) patients neither are differences in...
Abstract 4348313: Aldosterone Synthase Inhibitors Effectively Lower Blood Pressure but Increase Hyperkalemia Risk: A Meta-Analysis of Randomized Trials
Background: Aldosterone synthase inhibitors (ASIs) are a novel class targeting aldosterone biosynthesis, offering a mechanistically distinct approach from mineralocorticoid recepto...
Abstract 4364567: Enhancing Heart Regeneration and Repair after Myocardial Infarction through Inhibition of MicroRNA-762 by Targeting XAF1 and CMPK2.
Aim: Following myocardial infarction (MI), endothelial cells (ECs) and fibroblasts are key to tissue repair. Modulating their function could improve healing and cardiac recovery. G...
Abstract 4366213: Acute Severe Mitral Regurgitation Due to Flail Posterior Leaflet without Chordal Rupture Following Myosin Inhibitor Treatment of Hypertrophic Obstructive Cardiomyopathy
Background: Acute severe mitral regurgitation (MR) in patients with hypertrophic cardiomyopathy (HCM) is commonly caused by dynamic left ventricular outflow tract (LVOT) obstructio...
Abstract 4369220: In Vivo Cardiac Diffusion Tensor Imaging for the Differentiation between Hypertrophic Cardiomyopathy and Hypertensive Heart Disease: Insights into Myocardial Microstructure
Background: Left ventricular hypertrophy (LVH) is a common feature of both hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD), making differentiation through ma...
Abstract 4343952: Functional analysis of the intercalated disc
Introduction: Intercalated discs (ICDs) are specialized membrane domains that physically, electrically, and chemically connect adjacent cardiomyocytes (CMs). They preserve structur...
Abstract 4369285: Lower Risk of Cardiovascular Events in Patients with Heart Failure Initiated on Semaglutide 2.4 mg in the Real-world: Results from the SCORE-HF Study (Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity in the Real World – Heart Failure Population)
Background: In a prespecified analysis of the SELECT trial, semaglutide 2.4 mg reduced major adverse cardiovascular events (MACE) and heart failure (HF) composite outcomes in patie...
Abstract 4367469: Acute Myocardial Infarction and Stroke Outcomes Vary Substantially Across Private Equity Firms
Background: Private equity (PE) acquisitions of health care facilities have increased over the past decade, and growing evidence suggests this negatively affects patient outcomes....
Abstract 4367890: Video Assisted Education to Improve Blood Pressure Control in Ischemic Heart Disease Patients with Hypertension (V-EDUCATE): A Randomized controlled trial
Background: Blood pressure (BP) measurement adherence and medication adherence are essential for effective hypertension (HTN) management, particularly in patients with ischemic hea...
Abstract 4366431: β-1 Adrenoceptor is Responsible for the Apamin-Sensitive Small Conductance Ca <sup>2+</sup> -Activated K <sup>+</sup> Current Activation in Female Rabbit Ventricles
Background: Isoproterenol activates apamin-sensitive small conductance Ca 2+ -activated K + currents...
Abstract 4363444: Long-term outcomes of extensive aortic arch repair versus endovascular treatment in non-A non-B aortic dissection
Objective: This study presents a single-center retrospective analysis evaluating the long-term outcomes of patients with non-A non-B aortic dissection who underwent either total ar...
Abstract 4366855: AI-enabled Ascending Aorta and Pulmonary Trunk Volumetry in Coronary Artery Calcium Scans for Heart Failure Prediction: An AI-CVD Study within the Multi-Ethnic Study of Atherosclerosis (MESA)
Background: The AI-CVD initiative aims to extract all useful information from new or existing coronary artery calcium (CAC) scans. Previously, we have demonstrated that the automat...
Abstract 4366729: Same-Day Discharge Following Left Atrial Appendage Closure: Periprocedural Safety and Follow-up Outcomes
Introduction: Percutaneous left atrial appendage closure (LAAC) is an accepted non-pharmacological approach for stroke prevention in non-valvular AF in patients with contraindicati...
Abstract 4372977: Lactate Levels as a Prognostic Marker in Postpartum Hemorrhage: A Comparison with Shock Index, MEWS, and mREMS in the Emergency Department
Background: Postpartum hemorrhage (PPH) remains one of the leading causes of maternal morbidity and mortality worldwide. Rapid identification of women at risk of poor outcomes is e...
Abstract 4354222: Deep Learning Prediction of Left Atrial Structure and Function from 12-lead Electrocardiograms
Introduction: Abnormalities in the function and structure of the left atrium, called atrial cardiopathy, are a precursor of atrial fibrillation (AF) and an important risk factor fo...
Abstract 4349165: SGLT2 Inhibitor Therapy and Clinical Outcomes in HIV-Related Cardiomyopathy
Background: HIV cardiomyopathy (HIV-CM) is associated with significant morbidity and mortality. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have benefits in heart failure (H...
Abstract 4369597: Real-World Safety Profile of Mavacamten in Adults With Hypertrophic Cardiomyopathy: Insights From the FAERS Database
Background: Mavacamten, a novel cardiac myosin inhibitor, has emerged as a targeted therapy for obstructive hypertrophic cardiomyopathy (HCM). While clinical trials have demonstrat...
Abstract 4371071: Statin Therapy for Primary Prevention of Cardiovascular Disease in Patients with Diabetes: A Meta-Analysis of 100,000+ Subjects
Background: Patients with diabetes mellitus have a substantially increased risk for cardiovascular disease (CVD), even without prior events. While statin therapy is widely recommen...
Abstract 4369763: Reevaluating Lipoprotein(a) Levels and Risk of All-Cause Mortality in the Setting of Primary Prevention: A Retrospective Cohort Study
Introduction: Elevated lipoprotein(a) [Lp(a)] levels (≥30 mg/dL or ≥50 mg/dL) have been associated with increased risk of cardiovascular diseases (CVD), including myocardial infarc...
Abstract 4344937: The Impact of English Language Proficiency on Outcomes After Cardiovascular Surgery
Introduction: Language barriers represent an often-overlooked determinant of health equity. This study evaluates the impact of limited English proficiency (LEP) on major adverse ca...
Abstract 4373373: Attomolar-Sensitivity Plasma Proteomics Identifies Fat Depot-Specific Inflammatory Biomarkers Related to CKM Syndrome: The Dallas Heart Study
Introduction: Excess or dysfunctional adipose tissue contributes to cardio-kidney-metabolic (CKM) syndrome through the secretion of proinflammatory mediators. However, fat depot-sp...
Abstract 4372870: IL-37 contributes to the attenuation of inflammation and atrial fibrillation associated with right heart disease.
Introduction: Atrial Fibrillation (AF) is the most common cardiac arrhythmia. Age, obesity as well as heart failure, diabetes or right heart disease (RHD) induced by pulmonary arte...
Abstract 4365307: Burden of uncontrolled hypertension in real world practice: Insights from iCaReMe Global Registry
Background: Despite extensive evidence of strict blood pressure (BP) control benefits in preventing hypertension (HTN)-related morbidity and mortality, HTN control rates (defined a...
Abstract 4365721: Cardiac Magnetic Resonance Imaging Derived Extracellular Volume Correlates with Reference Standard Measures of Ventricular Stiffness Derived from Pressure-Volume Loop Analysis in Single Right Ventricle Patients
Background: Patients with single right ventricles (SRV) are exposed to conditions that predispose them to myocardial fibrosis and ventricular dysfunction. The assessment of extrace...