Circulation

When the Target Is Not the Driver: Rethinking LDL in Cardiac Allograft Vasculopathy

Deep Learning–Based Continuous QT Monitoring to Identify High-Risk Prolongation Events After Class III Antiarrhythmic Initiation

BACKGROUND: Drug-induced QT prolongation after successful inpatient loading of class III antiarrhythmics may occur during routine outpatient care. Insertable cardiac monitors offer...

Conceptual Models to Explain Heart Failure With a Preserved Ejection Fraction: A Tale of Futility, Frustration, and Perhaps, Fruition

N-Palmitoyl Glutamine Is a Candidate Mediator of Cardiorespiratory Fitness

BACKGROUND: Cardiorespiratory fitness is an integrative measure of cardiometabolic health and predictor of survival, yet little is known about its molecular underpinnings. Small mo...

Dapagliflozin Reduces Epicardial Adipose Tissue and Myocardial Fibrosis in Subclinical Heart Failure: The DAPA-EAT Trial

Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes From the STORM-PE Trial

BACKGROUND: Patients with intermediate-high risk pulmonary embolism (PE) have an elevated right ventricular (RV) to left ventricular (LV) diameter ratio and are at risk of early cl...

Cardiac Allograft Vasculopathy Inhibition With Alirocumab: The CAVIAR Trial

BACKGROUND: Cardiac allograft vasculopathy is an important cause of mortality after heart transplantation (HT). Dyslipidemia is a major contributor to the development of cardiac al...

Response by Tanguturi and Elmariah to Letter Regarding Article, “Electronic Provider Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: A Randomized Clinical Trial”

Letter by Huang et al Regarding Article, “Electronic Provider Notification to Facilitate the Recognition and Management of Severe Aortic Stenosis: A Randomized Clinical Trial”