Circulation

Inactivation of RhoA for Hypertension Treatment Through the TRPV4–RhoA–RhoGDI1 Axis

BACKGROUND: The RhoA (Ras homolog family member A) signaling pathway is pivotal in regulating vascular smooth muscle cells (VSMCs) function and blood pressure homeostasis. Current inhibito...

Deceptive Clues: When the Obvious Isn’t the Answer

To Loop or Not to Loop? Why and How Cardiac Invasive Pressure-Volume Relations Remain Important

Response by Ho et al to Letter Regarding Article, “A Proteomics-Based Approach for Prediction of Different Cardiovascular Diseases and Dementia”

The Impact of Fontan Circulatory Failure on Heart Transplant Survival: A 20-Center Retrospective Cohort Study

BACKGROUND: Fontan circulatory failure (FCF) is a chronic state in palliated single ventricle heart disease with high morbidity and mortality rates, including heart failure, multis...

Sit-Stand Transitions in Postmenopausal Women: Big Implications for a Small Change

Letter by Wu and Zheng Regarding Article, “A Proteomics-Based Approach for Prediction of Different Cardiovascular Diseases and Dementia”

Mitochondrial One-Carbon Metabolism Drives CD34-Lineage Cells to Differentiate Into T Follicular Helper Cells to Form Tertiary Lymphoid Organs in Transplant Arteriosclerosis

BACKGROUND: Allograft arteriosclerosis, a significant cause of graft failure, is linked to the formation of tertiary lymphoid organs. T follicular helper (Tfh) cells are a vital subset of...

Impacts of Reducing Sitting Time or Increasing Sit-to-Stand Transitions on Blood Pressure and Glucose Regulation in Postmenopausal Women: Three-Arm Randomized Controlled Trial

BACKGROUND: Public health and clinical guidelines identify the importance of sedentary behaviors for cardiovascular diseases, particularly among postmenopausal women. The goal of t...

Investigating the Risk of Arrhythmogenesis Associated With Fentanyl Abuse Using Human and Mouse Cardiomyocytes