Circulation
Articles in this Issue
Major Adverse Cognitive Events (MACE-Cog): A New “MACE” Framework for Cognitive Outcomes in Cardiovascular Diseases and Stroke
Cardiovascular diseases, particularly stroke, are leading causes of dementia. Several common cardiac interventions such as coronary artery bypass grafting and transcatheter aortic valve implantation a...
CD40-TRAF2/3/5 Signaling Promotes Cardiac Repair by Mediating Macrophage Efferocytosis After Myocardial Infarction
BACKGROUND: After myocardial infarction (MI), macrophage-mediated clearance of dead cells, a process known as efferocytosis, represents a pivotal role in tissue remodeling. Efficie...
Telehealth for Community-Engaged Cardiovascular Care in Rural Populations
Opportunistic Coronary Artery Calcium Screening: Time for Clinical Implementation
Letter by Li and Xiong Regarding Article, “Short-Term Anticoagulation Versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure: The ANDES Randomized Clinical Trial”
Response by Rodés-Cabau et al to Letter Regarding Article, “Short-Term Anticoagulation Versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure: The ANDES Randomized Clinical Trial”
Cardiovascular-Kidney-Metabolic Syndrome: A User’s Guide to the Guidelines
Translational Cardiovascular Science for the <i>Circulation</i> Community
Cardiovascular-Kidney-Metabolic Syndrome: Population and Policy Implications: 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome
Contextualizing Results and Recommendations
Use of Predicted Risk and Expected Benefit to Guide Decision-Making in Cardiovascular-Kidney-Metabolic Syndrome for the Primary Prevention of Cardiovascular Disease: A Scientific Statement From the American Heart Association and American College of Cardiology
Current clinical practice guidelines for the primary prevention of cardiovascular disease recommend risk assessment to align the type and intensity of preventive efforts with an individual’s risk. The...
Letter by Nayyar Regarding Article, “Geometric Features of Ventricular Tachycardia Corridors in Patients With Ischemic Cardiomyopathy”
Beyond Siloed Care: The Promise and Challenge of Cardiovascular-Kidney-Metabolic Syndrome
Cardiovascular–Kidney–Metabolic Syndrome: A Historic Perspective
2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
AIM The “2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome” retires, replaces, and expands upon t...
Targeting E3 Ubiquitin Ligase Hrd1 Prevents Myocardial Ischemia-Reperfusion Injury Through Enhancing ALDH2 Enzymatic Activity
BACKGROUND: Myocardial ischemia-reperfusion (I/R) injury presents a significant clinical challenge characterized by a complex pathological mechanism. The role of protein ubiquitina...
Letter by Zhang and Zhang Regarding Article, “Short-Term Anticoagulation Versus Dual Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure: The ANDES Randomized Clinical Trial”
2026 Cardiovascular-Kidney-Metabolic Guidelines: Practical Implementation Strategies
Response by Xu et al to Letter Regarding Article, “Geometric Features of Ventricular Tachycardia Corridors in Patients with Ischemic Cardiomyopathy”
Contrastive Machine Learning to Quantify Hypertensive Multiorgan Damage and Identify New Disease Phenotypes: A Multinational Multimodal Study
BACKGROUND: Hypertension induces structural and functional damage in multiple organs. Evidence of subclinical damage increases risk of vascular events and death but can be difficul...
Medial Arterial Calcification in a 4500-Year-Old Egyptian King: A Deep-Time View of a Vascular Calcification Continuum
Predictive Value of Coronary Artery Calcium Score From Nongated Chest CT Scans Compared With Gated Scans and Incidence of Cardiovascular Events
BACKGROUND: Data on the prognostic value of incidental coronary artery calcium (CAC) from nongated chest computed tomography scans are limited. Using paired computed tomography sca...