Circulation
Articles in this Issue
Abstract 4367893: Growing Use, Evolving Risk: A Contemporary Profile of Heart-Liver Transplantation
Background: Combined heart–liver transplantation (CHLT) offers long-term survival comparable with isolated heart transplantation. National use keeps rising, and 2019 was the first...
Abstract 4369360: Vutrisiran Healthcare Resource Utilization, Costs, Discontinuation, and Mortality: a Retrospective Database Analysis
Introduction: Vutrisiran is approved for hereditary transthyretin amyloid polyneuropathy (06/2022) and transthyretin amyloid cardiomyopathy (ATTR-CM; 03/2025). Real-world data on v...
Abstract 4361929: Improving Early Detection of Hypertrophic Cardiomyopathy Using Viz-HCM: A Quality Improvement Initiative Leveraging Artificial Intelligence-Assisted EKG HCM Screening
Background: Hypertrophic cardiomyopathy (HCM) remains underdiagnosed despite an estimated prevalence of 1 in 500 in the general population. Due to its often asymptomatic presentati...
Abstract 4369218: Association of Finerenone Use With Cardiovascular and Renal Outcomes in Patients With HFpEF and CKD: A Propensity-Matched Real-World Comparative Effectiveness Study
Background: Heart failure with preserved ejection fraction (HFpEF) complicated by chronic kidney disease (CKD) represents a high-risk phenotype with limited therapeutic options. Fi...
Abstract 4341346: Cardiovascular Risk Factors and Disparities Among Middle Eastern and North African Americans
Background: Middle Eastern and North African (MENA) Americans are an understudied minority group. Their classification as White in the U.S. racial system limits available health da...
Abstract 4371138: Polygenic Risk Score–Based Enrichment of Primary Prevention Cohorts for Atherosclerotic Cardiovascular Disease Trials
Background: Clinical trials for coronary artery disease (CAD) face significant challenges in cost, duration, and participant recruitment, especially in primary prevention settings....
Abstract 4342417: Predictors of Cognitive Resilience in the Multi-Ethnic Study of Atherosclerosis
Background: Identifying modifiable factors of cognitive resilience (CR), an individual’s ability to sustain better-than-expected cognitive performance given the degree of brain pat...
Abstract 4363413: Safety and Effectiveness of Vascular Closure Devices in the Electrophysiology Laboratory: a Systematic Review and Meta-analysis
Introduction: Manual compression and figure of eight sutures remain the standard practice (SP) for achieving hemostasis following venous access for electrophysiology (EP) procedure...
Abstract 4369512: Porcelain Left Atrium as seen on Coronary Angiogram
Background: Circumferential calcification of the left atrium, commonly referred to as "porcelain atrium" or "coconut atrium," was first documented in 1898 in patients with rheumati...
Abstract 4370409: Iatrogenic aortocoronary dissection treated with bail-out stenting and requiring triple therapy: A case report
Introduction: Iatrogenic aortocoronary dissection (IACD) is a life-threatening complication of coronary angiogram. Clinica...
Abstract 4371374: ARRHYTHMOGENIC POTENTIAL OF BARORECEPTOR ACTIVATION THERAPY
Discussion of Case: A 69-year-old male with HF-rEF secondary to nonischemic cardiomyopathy presented with persistent NYHA class III symptoms despite optimized medical therapy, CRT-...
Abstract 4369623: P2Y12 Inhibitor Monotherapy as a Safer and Equally Effective Alternative to Dual Antiplatelet Therapy in Patients Undergoing Percutaneous Coronary Intervention: A Comprehensive Meta-Analysis of 52,475 Patients
Background: Current guidelines recommend 12 months of DAPT after PCI in ACS patients; however, prolonged use is associated with increased bleeding risk. Emerging strategies propose...
Abstract 4360941: Impact of Elevated Lipoprotein(a) on Cardiovascular Events in patients with premature ASCVD: A Nationally Representative Sample of US Medicare, Medicaid, and Commercial Enrollees
Background: Atherosclerotic cardiovascular disease (ASCVD) is considered premature if diagnosed before age 55 years in men or 65 years in women. Elevated Lp(a) is an independent, c...
Abstract 4363039: Patterns of Follow-up Lipid Testing and Statin Initiation among Young Adults with Elevated Lipid Levels in a US Integrated Healthcare System
Background: More than 50% of US young adults are estimated to have low-density lipoprotein cholesterol (LDL-C) ≥100 mg/dL. Compared to older adults, young adults are less likely to...
Abstract 4357789: Prebiotic Banana (musa sapientum l.) Snack Attenuates Cardiac Autonomic Imbalance by Modulating Mitochondrial Oxidative Stress in Prediabetic Rats
Background: Cardiometabolic impairment and gut dysbiosis are commonly observed in obesity. We previously demonstrated that modulation of the gut microbiota using prebiotic and prob...
Abstract 4365155: National Trends And Related Outcomes For Hypertensive Crisis Amongst Adult Patients With Underlying Congenital Heart Disease
Introduction: There has been a steady rise in the prevalence of hypertension in adults with congenital heart disease (ACHD) and is now comparable to the general population. The bur...
Abstract 4366557: Assessment of Myocardial Function Recovery in Peripartum Cardiomyopathy: Role of Global Longitudinal Strain and Myocardial Work
Background: Peripartum cardiomyopathy (PPCM) occurs in late pregnancy or early postpartum and is characterized by left ventricular (LV) systolic dysfunction. Although approximately...
Abstract 4363938: Combination Glucagon-Like Peptide-1 Receptor Agonist and Sodium-Glucose Cotransporter-2 Inhibitor Therapy Reduces Admissions and Death in Patients with Heart Failure with Reduced Ejection Fraction
Background: Heart failure with reduced ejection fraction (HFrEF) is characterized by impaired systolic function and invariably presents with co-existing diastolic dysfunction, crea...
Abstract 4364299: Yentl Syndrome Refuted: Cholesterol Management from a Multicenter Healthcare System
Background: According to the GOULD registry, the median low-density lipoprotein (LDL) after coronary revascularization is 99mg/dL. Similarly, a large-scale New York City health sys...
Abstract 4368802: Association Between Individual Social Determinants of Health and Incident PAD: A CRIC Study
Introduction: Peripheral arterial disease (PAD) affects approximately 21 million people in the United States and will rise by 2030. Individuals with chronic kidney disease (CKD) ar...
Abstract 4366672: PAH-former: Transfer Learning for Efficient Discovery of Pulmonary Arterial Hypertension-Associated Genes
Introduction: Pulmonary arterial hypertension (PAH) is a severe disease characterized by pulmonary vascular remodeling. Current research is restricted by its rarity and lack of acc...
Abstract 4366628: 4D Cardiac Optogenetics Enable Complex Arrhythmia Modelling and Precise Interventional Simulation
Background: Cardiac arrhythmias are a major cause of morbidity and mortality. Yet, current in vitro arrhythmia models neither permit reproducible creation of complex arrhythmia sub...
Abstract 4355713: Despite Alteration in Antigenic Peptides Presented by H2-D <sup>b</sup> , the Recognition Mechanism of a Cross-reactive T Cell Receptor Remains Largely Conserved in Type 1 Diabetes
Background: Type 1 diabetes (T1D) is an autoimmune disorder resulting from destruction of beta cells in the pancreas by autoreactive CD8 T cells. AI4 is a highly pathogenic CD8 T c...
Abstract 4370562: Association of High-Sensitivity C-Reactive Protein with Chronic Kidney Disease in Patients with Hypertension
Background: Patients with chronic kidney disease (CKD) encounter with chronic inflammatory state; however, the magnitude of the association between high-sensitivity C-reactive prot...
Abstract Sun705: Comparison of 5-Year Neurologically Intact Survival Between an Automated Head Up CardiopulmonaryResuscitation Registry and a National Cardiac Arrest Registry
Background: Pre-clinical animal studies have demonstrated improved cerebral blood flow and neurological survival with Automated Head Up Position (AHUP) cardiopulmonary resuscitatio...