Circulation
Articles in this Issue
Sirolimus-Eluting Balloon With Provisional Stenting Versus Systematic Drug-Eluting Stent Implantation to Treat De Novo Coronary Lesions: A Randomized, Open-Label, Noninferiority Trial
BACKGROUND: Implantation of drug eluting stents (DESs) is currently the default approach for percutaneous coronary interventions, but long-term adverse events still exist. An appro...
Loss of ATP-Dependent Citrate Lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling
BACKGROUND: Metabolic adaptation and maladaptation are hallmarks of the failing heart and may be a target for therapeutic interventions. For example, sustain...
Ethics of Navigating Organ Scarcity in Heart Transplantation
Stent-Free PCI: Have We Found the SELUTION?
Rapid Ultraoxygenated Recovery Without Preimplant Reanimation Using Older Donation After Circulatory Death Heart Donors
From Discovery to Impact in the <i>Circulation</i> Life Cycle
Comparative Efficacy of Transfusion Strategies in Women and Men With Myocardial Infarction and Anemia: Prespecified Secondary Findings From the MINT Trial
BACKGROUND: The optimal transfusion strategy in patients with acute myocardial infarction (AMI) and anemia may be influenced by sex differences in pathophysiology and cardiovascula...
Incremental Prognostic Value of Subendocardial Myocardial Flow Reserve in Patients With Normal Perfusion
BACKGROUND: Although the prognostic utility of positron emission tomography (PET) myocardial flow reserve (MFR) is well established, emerging data suggest th...
SIRT5 Ameliorates Cardiac Fibrosis via PCK2 Desuccinylation-Mediated Metabolic Reprogramming in Cardiac Fibroblasts
BACKGROUND: SIRT5 (sirtuin 5) is a member of the sirtuin family known to regulate cardiac metabolism, aging, and function. However, its role in cardiac fibroblast (CFB) metabolism,...
Cold Oxygenated Rapid Recovery in Heart Donation After Circulatory Death
Diagnostic Approach to Cardiac Sarcoidosis
Cardiac sarcoidosis is a granulomatous myocarditis, classified by some authorities as an infiltrative cardiomyopathy and by others as an inflammatory cardiomyopathy, that carries an elevated risk of l...
Cracking the Code of Cardiac ATP-Dependent Citrate Lyase With Wet and Dry Tools
Ethical Considerations for Heart Organ Allocation: Current Landscape and Future Policy Guidance: A Scientific Statement From the American Heart Association
The heart transplant allocation system is evolving in response to increasing demand for donor organs, technological advances, and changes in medical decision-making. In this evolving landscape, the hi...
Does Characterization of Phenotypic Heterogeneity Provide Mechanistic Insights or Influence the Response to Treatment? Experience in Positive and Neutral Trials in Patients With Heart Failure and a Preserved Ejection Fraction
At a time when there was no unifying hypothesis and no broadly effective treatments for heart failure with a preserved ejection fraction (HFpEF), it was proposed that HFpEF represented a multitude of...